Maternal B lymphocytes specific for paternal histocompatibility antigens are partially deleted during pregnancy

Journal of Immunology

Volumn 161, Issue 6, 1998, Pages 2677-2683

  Aït Azzouzene, Djemel ^a   Gendron, Marie Claude ^b   Houdayer, Monique ^a   Langkopf, Anja ^a   Bürki, Kurt ^c   Nemazee, David ^d   Kanellopoulos Langevin, Colette ^a,b  

^a SORBONNE UNIVERSITÉ   (France)

^b INSTITUT JACQUES MONOD   (France)

^c Sandoz Pharma Ltd   (Switzerland)

^d NATIONAL JEWISH MEDICAL AND RESEARCH CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALLOANTIGEN; HISTOCOMPATIBILITY ANTIGEN; LYMPHOCYTE RECEPTOR;

ANIMAL CELL; ANTIGEN BINDING; ANTIGEN RECOGNITION; ARTICLE; B LYMPHOCYTE; IMMUNOGLOBULIN BLOOD LEVEL; LYMPHOCYTE SUBPOPULATION; NONHUMAN; PARAAORTIC LYMPH NODE; PREGNANCY; PRIORITY JOURNAL; SPLEEN CELL;

ANIMALS; B-LYMPHOCYTE SUBSETS; BONE MARROW CELLS; CLONAL DELETION; CROSSES, GENETIC; EPITOPES; FEMALE; FLOW CYTOMETRY; H-2 ANTIGENS; IMMUNOGLOBULIN M; LYMPHOCYTE COUNT; LYMPHOPENIA; MALE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; PREGNANCY; PREGNANCY, ANIMAL; SEX CHARACTERISTICS; SPLEEN;

EID: 0032530693     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (37)

1. Medawar. P. B. 1953. Some immunological and endocrinological problems raised by the evolution of viviparity in vertebrates. Symp. Soc. Exp. Biol. 44:320.
2. Rocklin, R. E., J. L. Kitzmiller, and M. D. Kaye. 1979. Immunobiology of the maternal-fetal relationship. Annu. Rev. Med. 30:375.
3. Sargent, I. L. 1993. Maternal and fetal immune responses during pregnancy. Exp. Clin. Immunogenet. 10:85.
4. Hunt, J. S. 1992. Immunobiology of pregnancy. Curr. Opin. Immunol. 4:591.
5. Hunt, J. S., and H. T. Orr. 1992. HLA and maternal-fetal recognition. FASEB J. 6:2344.
6. Bell, S. C., and W. D. Billington. 1983. Anti-fetal alloantibody in the pregnant female. Immunol. Rev. 75:5.
7. Faulk, W. P., and J. A. McIntyre. 1983. Immunological studies of human trophoblast: markers, subsets, and functions. Immunol. Rev. 75:139.
8. Oudejans, C. B. M., P. Krimpenfort, H. L. Ploegh, and C. J. L. M. Meijer. 1989. Lack of expression of HLA-B27 gene in transgenic mouse trophoblast. J. Exp. Med. 169:447.
9. Clark, D. 1991. Controversies in reproductive immunology. Crit. Rev. Immunol. 11:215.
10. 2-microglobulin RNA transcripts. Immunogenetics 22:441.
11. 2-microglobulin transcripts at early stages of mouse development. J. Immunol. 147:2740.
12. Toder, V., M. Blank, G. Drizlikh, and L. Nebel. 1982. Placental and embryo cells can induce the generation of cytotoxic lymphocytes in vitro. Transplantation 33:196.
13. Herzenberg, L. A., D. W. Bianchi, J. Schröder, H. M. Cann, and G. M. Iverson. 1979. Fetal cells in the blood of pregnant women: detection and enrichment by fluorescence-activated cell sorting. Proc. Natl. Acad. Sci. USA 76:1453.
14. Bonney, E. A., and P. Matzinger. 1997. The maternal immune system's interaction with circulating fetal cells. J. Immunol. 158:40.
15. Shimamura, M., S. Ohta, R. Suzuki, and K. Yamazaki. 1994. Transmission of maternal blood cells to the fetus during pregnancy: detection in mouse neonatal spleen by immunofluorescence flow cytometry and polymerase chain reaction. Blood 83:926.
16. Nemazee, D. A., and K. Bürki. 1989. Clonal deletion of B lymphocytes in a transgenic mouse bearing anti-MHC class I antibody genes. Nature 337:562.
17. Russell, D. M., Z. Dembic, G. Morahan, J. F. A. P. Miller, K. Bürki, and D. Nemazee 1991. Peripheral deletion of self-reactive B cells. Nature 354:308.
18. Nemazee, D., D. Russell, B. Arnold, G. Hammerling, J. Allison, J. F. Miller, G. Morahan, and K. Bürki. 1991. Clonal deletion of autospecific B lymphocytes. Immunol. Rev. 122:117.
19. Lang, J., M. Jackson, L. Teyton, A. Brunmark, K. Kane, and D. Nemazee. 1996. B cells are exquisitely sensitive to central tolerance and receptor editing induced by ultralow affinity membrane-bound antigen. J. Exp. Med. 184:1685.
20. Tiegs, S. L., D. M. Russell, and D. Nemazee. 1993. Receptor editing in self-reactive bone marrow B cells. J. Exp. Med. 177:1009.
21. Medina, K. L., G. Smithson, and P. Kincade. 1993. Suppression of B lymphopoiesis during normal pregnancy. J. Exp. Med. 178:1507.
22. Medina, K. L., and P. Kincade. 1994. Pregnancy-related steroids are potential negative regulators of B lymphopoiesis. Proc. Natl. Acad. Sci. USA 91:5382.
23. Tafuri, A., J. Alferink, P. Möller, G. J. Hämmerling, and B. Arnold. 1995. T cell awareness of paternal alloantigens during pregnancy. Science 270:630.
24. Fowler, J. H., and D. J. Nash. 1968. Erythropoiesis in the spleen and bone marrow of the pregnant mouse. Dev. Biol. 18:331.
25. Ozato, K., Y.-J. Wan, and B. M. Orrison. 1985. Mouse major histocompatibility class I gene expression begins at midsomite stage and is inducible in earlier-stage embryos by Interferon. Proc. Natl. Acad. Sci. USA 82:2427.
26. David-Watine, B., A. Israel, and P. Kourilsky. 1990. The regulation and expression of MHC class I genes. Immunol. Today 11:286.
27. Whitelaw, P. F., and B. A. Croy. 1996. Granulated lymphocytes of pregnancy. Placenta 17:533.
28. De, M., and G. W. Wood. 1991. Analysis of the number and distribution of macrophages, lymphocytes, and granulocytes in the mouse uterus from implantation through parturition. J. Leukocyte Biol. 50:381.
29. Goodnow, C. C., J. Crosbie, H. Jorgensen, R. A. Brink, and A. Basten. 1989. Induction of self-tolerance in mature peripheral B lymphocytes. Nature 342:385.
30. Hartley, S. B., J. Crosbie, R. Brink, A. A. Kantor, A. Basten, and C. C. Goodnow. 1991. Elimination from peripheral lymphoid tissues of self-reactive B lymphocytes recognizing membrane-bound antigens. Nature 353:765.
31. Pulendran, B., G. Kannourakis, S. Nouri, K. G. C. Smith, and G. J. V. Nossal. 1995. Soluble antigen can cause enhanced apoptosis of germinal-centre B cells. Nature 375:331.
32. Shokat, K. M., and C. C. Goodnow. 1995. Antigen-induced B-cell death and elimination during germinal-centre immune responses. Nature 375:334.
33. Mitchison, N. A. 1953. The effect on the offspring of maternal immunization in mice. J. Genet. 51:406.
34. Gorer, P. A., and Z. B. Mikulska. 1954. The antibody response to tumor inoculation: improved methods of antibody detection. Cancer Res. 14:651.
35. Spack, E., Jr., and M. Edidin. 1986. The class I MHC antigens of erythrocytes: a serologic and biochemical study. J. Immunol. 136:2943.
36. high and exhibit unique signaling characteristics. J. Immunol. 149:2533.
37. high splenic B cells are an immune developmental intermediate in the production of long-lived marrow-derived B cells. J. Immunol. 151:4431.