A novel function of Stat1α and Stat3 proteins in erythropoietin- induced erythroid differentiation of a human leukemia cell line

Blood

Volumn 92, Issue 2, 1998, Pages 462-471

  Kirito, Keita ^b   Uchida, Mie ^b   Takatoku, Masaaki ^b   Nakajima, Koichi ^b   Hirano, Toshio ^b   Miura, Yasusada ^b   Komatsu, Norio ^a  

^a JICHI MEDICAL UNIVERSITY   (Japan)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ERYTHROPOIETIN; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; REGULATOR PROTEIN;

ARTICLE; CANCER CELL CULTURE; CELL CYCLE; CELL DIFFERENTIATION; CELL LINEAGE; ERYTHROPOIESIS; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; LEUKEMIA CELL; PRIORITY JOURNAL;

EID: 0032528511     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v92.2.462.414k15_462_471     Document Type: Article

References (56)

1. Koury MJ, Bondurant MC: Maintenance by erythropoietin of viability and maturation of murine erythroid precursor cells. J Cell Physiol 137:65, 1988
2. Miura O, Nakamura N, Quelle FW, Witthuhn BA, Ihle JN, Aoki N: Erythropoietin induces association of the JAK2 protein tyrosine kinase with the erythropoietin receptor in vivo. Blood 84:1501, 1994
3. Gouilleux F, Pallard C, Dusanter FI, Wakao H, Haldosen LA, Norstedt G, Levy D, Groner B: Prolactin, growth hormone, erythropoietin and granulocyte-macrophage colony stimulating factor induce MGF-Stat5 DNA binding activity. EMBO J 14:2005, 1995
4. Pallard C, Gouilleux F, Charon M, Groner B, Gisselbrecht S, Dusanter FI: Interleukin-3, erythropoietin, and prolactin activate a STAT5-like factor in lymphoid cells. J Biol Chem 270:15942, 1995
5. Wakao H, Harada N, Kitamura T, Mui AL, Miyajima A: Interleukin 2 and erythropoietin activate STAT5/MGF via distinct pathways. EMBO 114:2527, 1995
6. Miura Y, Miura O, Ihle JN, Aoki N: Activation of the mitogen-activated protein kinase pathway by the erythropoietin receptor. J Biol Chem 269:29962, 1994
7. Ren H-Y, Komatsu N, Shimizu R, Okada K, Miura Y: Erythropoietin induces tyrosine phosphorylation and activation of phospholipase C-γ1 in a human erythropoietin-dependent cell line. J Biol Chem 269:19633, 1994
8. Schindler C, Fu XY, Improta T, Aebersold R, Darnell JEJ: Proteins of transcription factor ISGF-3: One gene encodes the 91 and 84-kDa ISGF-3 proteins that are activated by interferon α. Proc Natl Acad Sci USA 89:7836, 1992
9. Fu XY, Schindler C, Improta T, Aebersold R, Darnell JEJ: The proteins of ISGF-3, the interferon α-induced transcriptional activator, define a gene family involved in signal transduction. Proc Natl Acad Sci USA 89:7840, 1992
10. Komatsu N, Nakauchi H, Miwa A, Ishihara T, Eguchi M, Moroi M, Okada M, Sato Y, Wada H, Yawata Y, Suda T, Miura Y: Establish ment and characterization of a human leukemic cell line with megakaryocytic features: Dependency on granulocyte-macrophage colony-stimulating factor, interleukin 3, or erythropoietin for growth and survival. Cancer Res 51:341, 1991
11. Komatsu N, Yamamoto M, Fujita H, Miwa A, Hatake K, Endo T, Okano H, Katsube T, Fukumaki Y, Sassa S, Miura Y: Establishment and characterization of an erythropoietin-dependent subline, UT-7/Epo, derived from human leukemia cell line, UT-7. Blood 82:456, 1993
12. Chiba S, Takaku F, Tange T, Shibuya K, Misawa C, Sasaki K, Miyagawa K, Yazaki Y, Hirai H: Establishment and erythroid differentiation of a cytokine-dependent human leukemic cell line F-36: A parental line requiring granulocyte-macrophage colony-stimulating factor or interleukin-3, and a subline requiring erythropoietin. Blood 78:2261, 1991
13. Kirito K, Uchida M, Yamada M, Miura Y, Komatsu N: A distinct function of STAT proteins in erythropoietin signal transduction. J Biol Chem 272:16507, 1997
14. Komatsu N, Kirito K, Shimizu R, Kunitama M, Yamada M, Uchida M, Takatoku M, Eguchi M, Miura Y: In vitro development of erythroid and megakaryocytic cells from a UT-7 subline, UT-7/GM. Blood 89:4021, 1997
15. Kitamura T, Tange T, Terasawa T, Chiba S, Kuwaki T, Miyagawa K, Piao Y-F, Miyazono K, Urabe A, Takaku F: Establishment and characterization of a unique human cell line that proliferates dependently on GM-CSF, IL-3, or erythropoietin. J Cell Physiol 140:323, 1989
16. Nakajima K, Yamanaka Y, Nakae K, Kojima H, Ichiba M, Kiuchi N, Kitaoka T, Fukada T, Hibi M, Hirano T: A central role for Stat3 in IL-6-induced regulation of growth and differentiation in M1 leukemia cells. EMBO J 15:3651, 1996
17. Minami M, Inoue M, Wei S, Takeda K, Matsumoto M, Kishimoto T, Akira S: STAT3 activation is a critical step in gp130-mediated terminal differentiation and growth arrest of a myeloid cell line. Proc Natl Acad Sci USA93:3963, 1996
18. Shimozaki K, Nakajima K, Hirano T, Nagata S: Involvement of STAT3 in the granulocyte colony-stimulating factor-induced differentiation of myeloid cells. J Biol Chem 272:25184, 1997
19. Chretien S, Varlet P, Verdier F, Gobert S, Carton J-P, Gisselbrecht S, Mayeux P, Lacombe C: Erythropoietin-induced erythroid differentiation of the human erythroleukemia cell line TF-1 correlates with impaired STAT5 activation. EMBO J 15:4174, 1996
20. Iwatsuki K, Endo T, Misawa H, Yokouchi M, Matsumoto A, Ohtsubo M, Mori KJ, Yoshimura A: Stat5 activation correlates with erythropoietin receptor mediated erythroid differentiation of an erythroleukemia cell line. J Biol Chem 272:8149, 1997
21. Guimaraes JE, Berney JJ, Francis GE, Hoffbrand AV: The identification of mixed granulocytic-erythrocytic colonies in vitro. Exp Hematol 12:535,1984
22. Wagner BJ, Hayes TE, Hoban CJ, Cochran BH: The SIF binding element confers sis/PDGF inducibility onto the c-fos promoter. EMBO J 9:4477, 1990
23. Wakao H, Gouilleux F, Groner B: Mammary gland factor (MGF) is a novel member of the cytokine regulated transcription factor gene family and confers the prolactin response. EMBO J 13:2182, 1994
24. Kimura M, Takatsuki A, Yamaguchi I: Balsticidin S deaminase gene from Aspergillus terreus (BSD): A new drug resistance gene for transfection of mammalian cells. Biochem Biophys Acta 1219:653, 1994
25. Mosmann T: Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays. J Immunol Methods 65:55, 1983
26. Chomczynski P, Sacchi N: Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 162:156, 1987
27. Carroll M, Zhu Y, D'Andrea AD: Erythropoietin-induced cellu lar differentiation requires prolongation of the G1 phase of the cell cycle. Proc Natl Acad Sci USA 92:2869, 1995
28. Krosl J, Damen JE, Krystal G, Humphries RK: Erythropoietin and interleukin-3 induce distinct events in erythropoietin receptor-expressing BA/F3 cells. Blood 85:50, 1995
29. Ihara S, Nakajima K, Fukada T, Hibi M, Nagata S, Hirano T, Fukui Y: Dual control of neurite outgrowth by STAT3 and MAP kinase in PC 12 cells stimulated with interleukin-6. EMBO J 16:5345, 1997
30. Fukada T, Hibi M, Yamanaka Y, Takahashi-Tezuka M, Fujitani Y, Yamaguchi T, Nakajima K, Hirano T: Two signals are necessary for cell proliferation induced by a cytokine receptor gp130: Involvement of STAT3 in anti-apoptosis. Immunity 5:449, 1996
31. Marra F, Choudhury GG, Abboud HE: Interferon-γ-mediated activation of Stat1α regulates growth factor-induced mitogenesis. J Clin Invest 98:1218, 1996
32. Chin YE, Kitagawa M, Su W-CS, You Z-H, Iwamoto Y, Fu X-Y: Cell growth arrest and induction of cyclin-dependent kinase inhibitor p21 WAF-1/CIP1 mediated by STAT1. Science 272:719, 1996
33. Mantel C, Luo Z, Canfield J, Braun S, Broxmeyer HE: Involvement of p21cip-1 and p27kip-1 in the molecular mechanisms of steel factor-induced proliferative synergy in vitro and of p21cip-l in the maintenance of stem/progenitor cells in vivo. Blood 88:3710, 1996
34. LaBaer J, Garrett MD, Stevenson LF, Slingerland JM, Sandhu C, Chou HS, Fattaey A, Harlow E: New functional activities for the p21 family of CDK inhibitors. Genes Dev 11:847, 1997
35. Boeuf H, Hauss C, De Graeve F, Baran N, Kedinger C: Leukemia inhibitory factor-dependent transcriptional activation in embryonic stem cells. J Cell Biol 138:1207, 1997
36. Tillbrook PA, Ingley E, Williams JH, Hibbs ML, Klinken SP: Lyn tyrosine kinase is essential for erythropoietin-induced differentiation of J2E erythroid cells. EMBO 7:1610, 1997
37. Sharlow ER, Pacifici R, Crouse J, Batac J, Todokoro K, Wojchowski DM: Hematopoietic cell phosphatase negatively regulates erythropoietin-induced hemoglobinization in erythroleukemic SKT6 cells. Blood 90:2175, 1997
38. Migone T-S, Lin J-X, Cereseto A, Mulloy JC, O'Shea JJ, Franchini G, Leonard WJ: Constitutively activated Jak-STAT pathway in T cells transformed with HTLV-1. Science 269:79, 1995
39. Weber NR, Egen C, Wehinger J, Ludwig W, Gouilleux GV, Mertelsmann R, Finke J: Constitutive activation of STAT proteins in primary lymphoid and myeloid leukemia cells and in Epstein-Barr virus (EBV)-related lymphoma cell lines. Blood 88:809, 1996
40. Gouilleux GV, Gouilleux F, Desaint C, Claisse JF, Capiod JC, Delobel J, Weber NRM, Dusanter FI, Dreyfus F, Groner B, Prin L: STAT-related transcription factors are constitutively activated in peripheral blood cells from acute leukemia patients. Blood 87:1692, 1996
41. Carlesso N, Frank DA, Griffin JD: Tyrosyl phosphorylation and DNA binding activity of signal transducers and activators of transcription (STAT) proteins in hematopoietic cell lines transformed by Bcr/Abl. J Exp Med 183:811, 1996
42. Yu CL, Meyer DJ, Campbell GS, Lamer AC, Carter SC, Schwartz J, Jove R: Enhanced DNA-binding activity of a Stat3-related protein in cells transformed by the Src oncoprotein. Science 269:81, 1995
43. Cao X, Tay A, Guy GR, Tan YH: Activation and association of Stat3 with Src in v-Src-transformed cell lines. Mol Cell Biol 16:1595, 1996
44. Ohashi T, Masuda M, Ruscetti SK: Induction of sequence-specific DNA-binding factors by erythropoietin and the spleen focus-forming virus. Blood 85:1454, 1995
45. Harrison DA, Binari R, Nahreini TS, Gilman M, Perrimon N: Activation of a Drosophila Janus kinase (JAK) causes hematopoietic neoplasia and developmental defects. EMBO J 14:2857, 1995
46. Luo H, Hanratty WP, Dearolf CR: An amino acid substitution in the Drosophila hopTum-1 Jak kinase causes leukemia-like hematopoietic defects. EMBO J 14:1412, 1995
47. Luo H, Rose P, Barber D, Hanratty WP, Lee S, Roberts TM, D'Andrea AD, Dearolf CR: Mutation in the Jak kinase JH2 domain hyperactivates Drosophila and mammalian Jak-Stat pathways. Mol Cell Biol 17:1562, 1997
48. Takeda K, Noguchi K, Shi W, Tanaka T, Matsumoto M, Yoshida N, Kishimoto T, Akira S: Targeted disruption of the mouse Stat3 gene leads to early embryonic lethality. Proc Natl Acad Sci USA 94:3801, 1997
49. Durbin JE, Hackenmiller R, Simon MC, Levy DE: Targeted disruption of the mouse Stall gene results in compromised innate immunity to viral disease. Cell 84:443, 1996
50. Meraz MA, White JM, Sheehan KC, Bach EA, Rodig SJ, Dighe AS, Kaplan DH, Riley JK, Greenlund AC, Campbell D, Carver-Moore K, DuBois RN, Clark R, Aguet M, Schreiber RD: Targeted disruption of the Stat1 gene in mice reveals unexpected physiologic specificity in the JAK-STAT signaling pathway. Cell 84:431, 1996
51. Nakamura Y, Komatsu N, Nakauchi H: A truncated erythropoietin receptor that fails to prevent programmed cell death of erythroid cells. Science 257:1138,1992
52. Chretien S, Moreau-Gachelin F, Apiou F, Courtois G, Mayeux P, Dutrillaux B, Carton JP, Gisselbrecht S, Lacombe C: Putative oncogenic role of the erythropoietin receptor in murine and human erythroleukemia cells. Blood 83:1813, 1994
53. Pallard C, Gouilleux F, Charon M, Groner B, Gisselbrecht S, Dusanter-Fourt I: Interleukin-3, erythropoietin, and prolactin activate a STAT5-like factor in lymphoid cells. J Biol Chem 270:15942, 1995
54. Klingmuller U, Bergelson S, Hsiao JG, Lodish HF: Multiple tyrosine residues in the cytoplasmic domain of the erythropoietin receptor promote activation of STAT5. Proc Natl Acad Sci USA 93:8324, 1996
55. Reese TT, Gregory RC, Sharlow ER, Pacifici RE, Crouse JA, Todokoro K, Wojchowski DM: Epo-induced hemoglobinization of SKT6 cells is mediated by minimal cytoplasmic domains of the Epo or prolactin receptors without modulation of GATA-1 or EKLF. Growth Factors 14:161, 1997
56. Penta K, Sawyer ST: Erythropoietin induces the tyrosine phosphorylation, nuclear translocation, and DNA binding of STAT1 and STAT5 in erythroid cells. J Biol Chem 270:31282, 1995