Kinesin and cytoplasmic dynein in spinal spheroids with motor neuron disease

Journal of the Neurological Sciences

Volumn 159, Issue 1, 1998, Pages 38-44

  Toyoshima, Itaru ^a   Sugawara, Masashiro ^a   Kato, Kazumaro ^a   Wada, Chizu ^a   Hirota, Koichi ^b   Hasegawa, Kazuko ^c   Kowa, Hisayuki ^c   Sheetz, Michael P ^d   Masamune, Osamu ^a  

^a AKITA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b AKITA RED CROSS HOSPITAL   (Japan)

^c KITASATO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^d DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Amyotrophic lateral sclerosis; Cytoplasmic dynein; Kinesin; Molecular motor; Motor neuron disease; Spheroid

Indexed keywords

DYNEIN ADENOSINE TRIPHOSPHATASE; KINESIN;

ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MALE; MOTOR NEURON DISEASE; NERVE FIBER TRANSPORT; NEUROFILAMENT; PRIORITY JOURNAL; PROTEIN DETERMINATION; SPINAL CORD MOTONEURON;

AGED; AGED, 80 AND OVER; AMYOTROPHIC LATERAL SCLEROSIS; AXONS; CYTOPLASM; DYNEIN ATPASE; FEMALE; HUMANS; KINESIN; MALE; MIDDLE AGED; MOTOR NEURON DISEASE; MOTOR NEURONS; MUSCULAR ATROPHY, SPINAL; REFERENCE VALUES; SPINAL CORD;

EID: 0032528474     PISSN: 0022510X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0022-510X(98)00137-3     Document Type: Article

References (29)

1. Aizawa H., Sekine Y., Takemura R., Zhang Z., Nangaku M., Hirokawa N. Kinesin family in murine central nervous system. J. Cell Biol. 119:1992;1287-1296.
2. Breuer A.C., Lynn M.P., Atkinson M.B., Chou S.M., Wilbourn A.J., Marks K.E., Culver J.E., Fleegler E.J. Fast axonal transport in amyotrophic lateral sclerosis: an intra-axonal organelle traffic analysis. Neurology. 37:1987;738-748.
3. Carpenter S. Proximal axonal enlargement in motor neuron disease. Neurology. 18:1968;841-851.
4. Chou S.M., Hartmann H.A. Electron microscopy of focal neuroaxonal lesions produced by beta-beta-iminodipropionitrile (IDPN) in rats. I. The advanced lesions. Acta Neuropathol. (Berlin). 4:1965;590-603.
5. Collard J.F., Côté F., Julien J.P. Defective axonal transport in a transgenic mouse model of amyotrophic lateral sclerosis. Nature. 375:1995;61-64.
6. Côté F., Collard J., Julien J. Progressive neuronopathy in transgenic mice expressing the human neurofilament heavy gene: a mouse model of amyotrophic lateral sclerosis. Cell. 73:1993;35-46.
7. Delisle M.B., Carpenter S. Neurofibrillary axonal swellings and amyotrophic lateral sclerosis. J. Neurol. Sci. 63:1984;241-250.
8. Dillman J.F., Pfister K.K. Differential phosphorylation in vivo of cytoplasmic dynein associated with anterogradely moving organelles. J. Cell Biol. 127:1994;1671-1681.
9. Figlewicz D.A., Krizus A., Martinoli M.G., Meininger V., Dib M., Rouleau G.A., Julien J.P. Variants of the heavy neurofilament subunit are associated with the development of amyotrophic lateral sclerosis. Hum. Mol. Genet. 3:1994;1757-1761.
10. Friede RL. Changes in microtubules and neurofilaments in constricted, hypoplastic nerve fibers. Acta Neuropathol. 1975;V:216-25.
11. Go M.J., Tanaka H., Obata K., Fujita S.C. Developmental changes in phosphorylation state of neurofilament proteins in the chick embryonic optic nerve. Dev. Biol. 134:1989;85-102.
12. Hirano A., Donnenfeld H., Sasaki S., Nakano I. Fine structural observations of neurofilamentous changes in amyotrophic lateral sclerosis. J. Neuropathol. Exp. Neurol. 43:1984;461-470.
13. Hirokawa N., Sato Y.R., Kobayashi N., Pfister K.K., Bloom G.S., Brady S.T. Kinesin associates with anterogradely transported membranous organelles in vivo. J. Cell Biol. 114:1991;295-302.
14. Hirokawa N., Sato Y.R., Yoshida T., Kawashima T. Brain dynein (MAP1C) localizes on both anterogradely and retrogradely transported membranous organelles in vivo. J. Cell Biol. 111:1990;1027-1037.
15. Lee M.K., Marszalek J.R., Cleveland D.W. A mutant neurofilament subunit causes massive, selective motor neuron death: implications for the pathogenesis of human motor neuron disease. Neuron. 13:1994;975-988.
16. Martenson C., Stone K., Reedy M., Sheetz M. Fast axonal transport is required for growth cone advance. Nature. 366:1993;66-69.
17. Niclas J., Navone F., Hom B.N., Vale R.D. Cloning and localization of a conventional kinesin motor expressed exclusively in neurons. Neuron. 12:1994;1059-1072.
18. Papasozomenos S.C., Autilio-Gambetti L., Gambetti P. Reorganization of axoplasmic organelles following beta, beta'-iminodipropionitrile administration. J. Cell Biol. 91:1981;866-871.
19. Ramon y Cajal S. Degeneration and regeneration of the nervous system. Vol 2, London: Oxford Press, 1928:198-222.
20. Sasaki S., Kamei H., Yamane K., Maruyama S. Swelling of neuronal processes in motor neuron disease. Neurology. 38:1988;1114-1118.
21. Sasaki S., Maruyama S., Yamane K., Sakuma H., Takeishi M. Ultrastructure of swollen proximal axons of anterior horn neurons in motor neuron disease. J. Neurol. Sci. 97:1990;233-240.
22. Schmidt M.L., Carden M.J., Lee V.M., Trojanowski J.Q. Phosphate dependent and independent neurofilament epitopes in the axonal swellings of patients with motor neuron disease and controls. Lab. Invest. 56:1987;282-294.
23. Sheetz M.P., Martenson C.H. Axonal transport: beyond kinesin and cytoplasmic dynein. Curr. Opin. Neurobiol. 1:1991;393-398.
24. Steuer E.R., Wordeman L., Schroer T.A., Sheetz M.P. Localization of cytoplasmic dynein to mitotic spindles and kinetochores. Nature. 345:1990;266-268.
25. Toyoshima I., Yamamoto A., Masamune O., Satake M. Phosphorylation of neurofilament proteins and localization of axonal swellings in motor neuron disease. J. Neurol. Sci. 89:1989;269-277.
26. Toyoshima I., Yu H., Steuer E.R., Sheetz M.P. Kinectin, a major kinesin-binding protein on ER. J. Cell Biol. 118:1992;1121-1131.
27. Vale R.D. Microtubule-based motor proteins. Curr. Opin. Cell Biol. 2:1990;15-22.
28. Xu Z., Cork L.C., Griffin J.W., Cleveland D.W. Increased expression of neurofilament subunit NF-L produces morphological alterations that resemble the pathology of human motor neuron disease. Cell. 73:1993;23-33.
29. Yu H., Toyoshima I., Steuer E.R., Sheetz M.P. Kinesin and cytoplasmic dynein binding to brain microsomes. J. Biol. Chem. 267:1992;20457-20464.