The effects of 4-aminopyridine on motor evoked potentials in multiple sclerosis

Journal of the Neurological Sciences

Volumn 159, Issue 1, 1998, Pages 102-106

  Fujihara, Kazuo ^a,b   Miyoshi, Tasuku ^a  

^a KYUSHU ROSAI HOSPITAL   (Japan)

^b TOHOKU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

4 Aminopyridine; Motor evoked potential (MEP); Multiple sclerosis (MS)

Indexed keywords

4 AMINOPYRIDINE;

ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; EVOKED MUSCLE RESPONSE; FEMALE; HUMAN; INTRAVENOUS DRUG ADMINISTRATION; LATENT PERIOD; MALE; MULTIPLE SCLEROSIS; NERVE CELL EXCITABILITY; PRIORITY JOURNAL; SYNAPTIC TRANSMISSION;

4-AMINOPYRIDINE; ADULT; AGED; ARM; EVOKED POTENTIALS, MOTOR; FEMALE; HUMANS; INFUSIONS, INTRAVENOUS; LEG; MAGNETICS; MALE; MIDDLE AGED; MOTOR NEURONS; MULTIPLE SCLEROSIS; MUSCLE, SKELETAL; PHYSICAL STIMULATION; SKIN;

EID: 0032528372     PISSN: 0022510X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0022-510X(98)00143-9     Document Type: Article

References (15)

1. Bever Jr C.T.et al. The effects of 4-aminopyridine in multiple sclerosis patients: results of a randomized, placebo-controlled, double-blind, concentration-controlled, crossover trial. Neurology. 44:1994;1054-1059.
2. Britton T.C.et al. Variability of cortically evoked motor responses in multiple sclerosis. Electroencephogr Clin Neurophysiol (Evoked Potentials). 81:1991;186-194.
3. Eisen A.A., Shtybel W. Clinical experience with transcranial magnetic stimulation. Muscle Nerve. 13:1990;995-1011.
4. Glover W.E. The aminopyridines. Gen Pharmacol. 13:1982;259-285.
5. Ingram D.A.et al. Central motor conduction in multiple sclerosis: evaluation of abnormalities revealed by transcutaneous magnetic stimulation of the brain. J Neurol Neurosurg Psychiatry. 51:1988;487-494.
6. Jones S.M.et al. Lower extremity motor evoked potentials in multiple sclerosis. Arch Neurol. 48:1991;944-948.
7. Kandler R.H.et al. The role of magnetic stimulation as a quantifier of motor disability in patients with multiple sclerosis. J Neurol Sci. 106:1991;25-30.
8. Kandler R.H.et al. The role of magnetic stimulation as a quantifier of motor disability in patients with multiple sclerosis. J Neurol Sci. 106:1991;31-34.
9. Kurtzke J.F. Rating neurologic impairment in multiple sclerosis: an expanded disability status scale (EDSS). Neurology. 33:1983;1444-1452.
10. Poser C.M.et al. New diagnostic criteria for multiple sclerosis: guidelines for research protocols. Ann Neurol. 13:1983;227-231.
11. Sherratt R.M.et al. Effects of 4-aminopyridine on normal and demyelinated mammalian nerve fibers. Nature. 283:1980;570-572.
12. Sipe J.C.et al. A neurologic rating scale (NRS) for use in multiple sclerosis. Neurology. 34:1984;1368-1372.
13. van Diemen H.A.M.et al. The effect of 4-aminopyridine on clinical signs in multiple sclerosis: a randomized, placebo-controlled, double-blind, cross-over study. Ann Neurol. 32:1992;123-130.
14. van Diemen H.A.M.et al. 4-Aminopyridine induces functional improvement in multiple sclerosis patients: a neurophysiological study. J Neurol Sci. 116:1993;220-226.
15. Uges D.R., Huizinga T. 4-Aminopyridine; analysis of the substance and a method for the preparation of a solution for injection in man. Pharm Acta Helv. 56:1981;158-162.