Cytotoxic T cell response against the chimeric ETV6-AML1 protein in childhood acute lymphoblastic leukemia

Journal of Clinical Investigation

Volumn 102, Issue 2, 1998, Pages 455-462

  Yotnda, P ^a   Garcia, F ^a   Peuchmaur, M ^b   Grandchamp, B ^c   Duval, M ^b   Lemonnier, F ^a   Vilmer, E ^b   Langlade Demoyen, P ^a  

^a INSTITUT PASTEUR   (France)

^b HÔPITAL ROBERT DEBRÉ   (France)

^c BICHAT HOSPITAL   (France)

Author keywords

Chromosomal translocation; Cytotoxic T lymphocytes; ETV6 AML1; Leukemia

Indexed keywords

ACUTE LYMPHOBLASTIC LEUKEMIA; ANTIGEN EXPRESSION; ARTICLE; CHILDHOOD LEUKEMIA; CHROMOSOME 12; CHROMOSOME 21; CHROMOSOME TRANSLOCATION; CYTOTOXIC T LYMPHOCYTE; CYTOTOXICITY TEST; HUMAN; HUMAN TISSUE; PRIORITY JOURNAL; PROTEIN EXPRESSION;

EID: 0032527907     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI3126     Document Type: Article

References (22)

1. Boel, P., C. Wildmann, M.L. Sensi, R. Brasseur, J.C. Renauld, P. Coulie, T. Boon, and P. Van der Bruggen. 1995. A new gene encoding an antigen recognized on human melanomas by cytolytic T lymphocytes. Immunity. 2:167-175.
2. Rosenberg, S.A., and M.T. Lotz. 1986. Cancer immunotherapy using interleukine-2 and interleukine 7-activated lymphocytes. Annu. Rev. Immunol. 4: 681-709.
3. Kawakami, Y., S. Eliyahu, K. Sakaguchi, P.P. Robbins, L. Rivoltini, J.R. Yannelli, E. Appelle, and S.A. Rosenberg. 1994. Identification of the immunodominant peptides of the MART-1 human melanoma antigen recognized by the majority of HLA-A2-restricted tumor infiltrating lymphocytes. J. Exp. Med. 18:347-352.
4. Raynaud, S., H. Cavé, M. Baens, C. Bastard, V. Caheux, J. Grosgeorge, C. Guidal-Giroux, C. Guo, E. Vilmer, P. Marynen, and B. Grandchamp. 1996. The 12;21 translocation involving TEL and deletion of the other TEL allele: two frequently associated alterations found in childhood acute lymphoblastic leukemia. Blood. 87:2891-2897.
5. Cayuela, J.M., A. Baruchel, C. Orange, A. Madani, M.F. Aucler, M.T. Daniel, G. Schaison, F. Sigaux. 1996. TEL-AML1 fusion RNA as a new target to detect minimal residual disease in pediatric B-cell precursor acute lymphoblastic leukemia. Blood. 88:302-308.
6. Shurtleff, S.A., A. Buijs, F.G. Behm, J.E. Rubintz, S.C. Raimondi, M.L. Hancock, G.C. Chan, C.H. Pui, G. Grosveld, and J.R. Downing. 1995. TEL/ AML1 fusion resulting from a cryptic t(12;21) is the most common genetic lesion in pediatric ALL and defines a subgroup of patients with an excellent prognosis. Leukemia (Basingstoke). 9:1985-1989.
7. Golub, T.R., G.F. Barker, M. Lovett, and D.G. Gilliland. 1994. Fusion of PDGF receptor beta to a novel ets-like gene tel in chronic myelomonocytic leukemia with t(5;12) chromosomal translocation. Cell. 77:307-315.
8. Romana, S.P., H. Poirel, M. Leconiat, M.A. Flexor, M. Mauchauffé, P. Jonveaux, E.A. Macintyre, R. Berger, and O.A. Bernard. 1995. High frequency of t(12,21) in childhood B-lineage acute lymphoblastic leukemia. Blood. 86: 4263-4269.
9. Miyoshi, H., K. Shimizu, T. Kozu, N. Maseki, Y. Kaneko, and M. Ohki. 1993. t(8;21) breakpoints on chromosome 21 in acute myeloid leukemia are clustered within a limited region of a single gene. AML1. EMBO (Eur. Mol. Biol. Organ.) J. 27:15-21.
10. Agape, P., B. Gérard, H. Cavé, E. Vilmer, M.C. Lecomte, and B. Grandchamp. 1997. Analysis of ETV6 and ETV6-AML1 proteins in ALLs. Br. J. Haematol. 98:234-239.
11. + T lymphocytes. J. Immunol. 144:574-582.
12. Gravieli, Y., Y. Sherman, S.A. Ben-Sasson. 1992. Identification of programmed cell death in situ via specific labeling of nuclear fragmentation. J. Cell Biol. 119:493-501.
13. + T-cells binds very tightly to the restricting class I major histocompatibility complex protein on intact cells but not to the purified class I protein. Proc. Natl. Acad. Sci. USA. 88:11276-11280.
14. Falk, K., O. Rötzschke, S. Stevanovic, G. Jung, and H.G. Rammensee. 1991. Allele-specific motifs revealed by sequencing of self-peptides eluted from MHC molecules. Nature. 351:290-296.
15. Connan, F., F. Halvac, J. Hoebeke, J.G. Guillet, and J.A. Choppin. 1994. A simple assay for detection of peptides promoting the assembly of HLA class 1 molecules. Eur. J. Immunol. 24:777-780.
16. Bettoletti, A., F.V. Chisari, A. Penna, S. Guilhot, L. Galati, G. Missale, P. Fowler, H.J. Schlit, A. Vitiello, and R.W. Chesnut. 1993. Definition of a minimal optimal cytotoxic T cell epitope within the hepatitis B virus nucleocapsid protein. J. Virol. 67:2376-2380.
17. Langlade-Demoyen, P., J.-P. Levraud, P. Kourilsky, and J.-P. Abastado. 1994. Primary cytotoxic T lymphocytes induction using peptide stripped autologous cells. Int. Immunol. 6:1759-1766.
18. Celis, E.V., C. Tsai, R. Crimi, P.A. DeMars, R.W. Wentworth, H.M. Chesnut, A. Grey, A. Sette, and H.M. Serre. 1994. Induction of anti-tumor cytotoxic T lymphocytes in normal humans using primary cultures and synthetic epitopes. Proc. Natl. Acad. Sci. USA. 91:2105-2109.
19. Kristin, B.A., A. Deggerdal, C. Skjonsberg, E. Smeland, and E.K. Blomhoff. 1943. Constitutive expression of C-myc does not relieve cAMP-mediated growth arrest in human lymphoid REH cells. J. Cell. Physiol. 157:61-69.
20. Dethlefs, S., N. Escriou, M. Brahic, S. Van Der Werf, and Larsson-Sciard. 1997. Theiler's virus and mengo virus induce cross-reactive cytotoxic T lymphocytes restricted to the same immunodominant VP2 epitope in C57BL/6 mice. J. Virol. 71:5361-5376.
21. Quesnel, A., S.-H. Hsu, A. Delmas, M.W. Steward, Y. Trudelle, J.-P. Abastado. 1996. Efficient binding to the MHC class I Kd molecule of synthetic peptides in which the anchoring position 2 does not fit the consensus motif. FEBS Lett. 387:42-46.
22. Harada, M., K. Matsunaga, Y. Oguchi, H. Lijima, O. Ito, K. Tamada, G. Kimura, and K. Nomoto. 1995. The involvement of transforming growth factor b in the impaired antitumor T-cell response at the gut associated lymphoid tissue (GALT). Cancer Res. 55:6146-6151.