Nicotinic receptor desensitization and sensory gating deficits in schizophrenia

Biological Psychiatry

Volumn 44, Issue 2, 1998, Pages 98-106

  Griffith, Jay M ^a   O'Neill, Jaishri E ^a   Petty, Frederick ^a   Garver, David ^a   Young, David ^b   Freedman, Robert ^b  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b UNIVERSITY OF COLORADO   (United States)

Author keywords

Auditory event related potential; Cholinergic receptors; Desensitization; Habituation; Nicotine; Polysomnography

Indexed keywords

CHLORPROMAZINE; NICOTINE; NICOTINIC RECEPTOR; RISPERIDONE;

ADULT; ARTICLE; CLINICAL ARTICLE; DRUG RECEPTOR BINDING; EVOKED AUDITORY RESPONSE; FEMALE; HABITUATION; HUMAN; MALE; PATHOGENESIS; POLYSOMNOGRAPHY; PRIORITY JOURNAL; RECEPTOR DOWN REGULATION; RECEPTOR OCCUPANCY; SCHIZOPHRENIA; SENSORY NERVE CONDUCTION;

ACOUSTIC STIMULATION; ADMINISTRATION, CUTANEOUS; ADULT; DOUBLE-BLIND METHOD; ELECTROENCEPHALOGRAPHY; EVOKED POTENTIALS; EVOKED POTENTIALS, AUDITORY; FEMALE; HABITUATION, PSYCHOPHYSIOLOGIC; HUMANS; MALE; NICOTINE; PLACEBOS; POLYSOMNOGRAPHY; RECEPTORS, NICOTINIC; SCHIZOPHRENIA; SLEEP; SLEEP, REM;

EID: 0032527575     PISSN: 00063223     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-3223(97)00362-4     Document Type: Article

References (39)

1. Acheson G.H., Langohr H.L., Stnabury J.B. Sensitivity of skeletal muscle to intraarterial acetylcholine in normal and myasthenic man. J Clin Invest. 27:1948;439-445.
2. Adler L.E., Gerhardt G.A., Franks R., Baker N., Nagamoto H., Drebing C., et al. Sensory physiology and catecholamines in schizophrenia and mania. Psychiatry Res. 31:1989;297-309.
3. Adler L.E., Hoffer L.J., Wiser A., Freedman R. Cigarette smoking normalizes auditory physiology in schizophrenics. Am J Psychiatry. 150:1993;1856-1861.
4. Adler L.E., Hoffer L.J., Griffith J., Waldo M.C., Freedman R. Normalization by nicotine of deficient auditory sensory gating in the relatives of schizophrenics. Biol Psychiatry. 32:1992;607-616.
5. Adler L.E., Pachtman E., Franks R., Pecevich M., Waldo M.C., Freedman R. Neurophysiological evidence for a defect in neuronal mechanisms involved in sensory gating in schizophrenia. Biol Psychiatry. 17:1982;639-654.
6. Alam N., Szymusiak R., McGinty D. Local preoptic/anterior hypothalamic warming alters spontaneous and evoked neuronal activity in the magno-cellular basal forebrain. Brain Res. 696:1995;221-230.
7. Diagnostic and Statistical Manual of Mental Disorders. 3rd ed rev. 1987;American Psychiatric Press, Washington, DC.
8. Boutros N.N., Zouridakis G., Overall J. Replication and extension of P50 findings in schizophrenia. Clin Electroencephalography. 22:1991;40-45.
9. Braff D.L., Grillon C., Geyer M.A. Gating and habituation of the startle reflex in schizophrenic patients. Arch Gen Psychiatry. 49:1992;206-215.
10. Clementz B.A., Geyer M.A., Braff D.L. P50 suppression among schizophrenia and normal comparison subjects a methodological analysis . Biol Psychiatry. 41:1997;1035-1044.
11. Cullum C.M., Harris J.G., Waldo M.C., Smernoff E., Madison A., Nagamoto H.T., et al. Neurophysiological and neuropsychological evidence for attentional dysfunction in schizophrenia. Schizophr Res. 10:1993;131-141.
12. Erwin R.J., Mawhinney-Hee M., Gur R.C., Gur R.E. Midlatency auditory evoked responses in schizophrenia. Biol Psychiatry. 30:1991;430-442.
13. Freedman R., Adler L.E., Bickford P., Byerley W., Coon H., Cullum M., et al. Schizophrenia and nicotinic receptors. Harvard Rev Psychiatry. 2:1994;179-192.
14. Freedman R., Coon H., Myles-Worsley M., Orr-Urtreger A., Olincy A., Davisa A., et al. Linkage of a neurophysiological deficit in schizophrenia to a chromosome 15 locus. Proc Nat Acad Sci. 94:1997;587-592.
15. Freedman R., Hall M., Adler L.E., Leonard S. Evidence in postmortem brain tissue for decreased numbers of hippocampal nicotinic receptors in schizophrenia. Biol Psychiatry. 38:1995;22-33.
16. Garcia-Rill E., Biedermann J.A., Chambers T., Skinner R.D., Mirak R.E., Husain M., et al. Mesopohtive neurons in schizophrenia. Neuroscience. 66:1995;321-335.
17. Griffith J., Freedman R. Normalization of the auditory P50 gating deficit of schizophrenic patients after NREM, but not REM sleep. Psychiatry Res. 56:1995;271-278.
18. Griffith J., Hoffer L.D., Adler L.E., Zerbe G.O., Freedman R. Effects of sound intensity on a midlatency evoked response to repeated auditory stimuli in schizophrenic and normal subjects. Psychophysiology. 32:1995;460-465.
19. Griffith J., Waldo M., Adler L.E., Freedman R. Normalization of auditory sensory gating in schizophrenics after a brief period for sleep. Psychiatry Res. 49:1993;29-39.
20. Holzman P.S. Recent studies of psychophysiology in schizophrenia. Schizophr Bull. 13:1987;49-78.
21. Hory-Lee F., Frank E. The nicotinic blocking agents d-tubocurare and alpha-bungarotoxin save motoneurons from naturally occurring death in the absence of neuromuscular blockade. J Neurosci. 15:1995;6453-6460.
22. Judd L.L., McAdams L., Budnick B., Braff D.L. Sensory gating deficits in schizophrenia new results . Am J Psychiatry. 149:1992;488-493.
23. Kang D.-Y., Poole J., McCallin K., Fein G., Vinogradov S. Sensory gating deficit in schizophrenia Relation to catecholamine metabolites . Schizophr Res. 24:1997;234.
24. Kathmann N., Engel R.R. Sensory gating in normals and schizophrenics a failure to find strong P50 suppression in normals . Biol Psychiatry. 27:1990;1216-1226.
25. Lindvall O., Backlund E.-O., Fardel Sedvall G., Freedman R., Hoffer B., et al. Transplantation in Parkinson's disease Two cases of adrenal medullary grafts to putamen . Ann Neurol. 22:1987;455-468.
26. Luntz-Leybman V., Bickford P., Freedman R. Cholinergic gating of response to auditory stimuli in rat hippocampus. Brain Res. 587:1992;130-136.
27. McGhie A., Chapman J.S. Disorders of attention and perception in earlier schizophrenia. Br J Med Psychol. 34:1961;103-116.
28. Nagamoto H.T., Adler L.E., Waldo M.C., Freedman R. Sensory gating in schizophrenics and normal controls effects of changing stimulation interval . Biol Psychiatry. 25:1989;549-561.
29. Neuchterlein K.H. Vigilance in schizophrenia and related disorders. Steinhauer S.R., Gruzelier J.H., Zubin J. Handbook of Schizophrenia, Vol. 5 Neuropsychology, Psychophysiology and Information Processing . 1991;397-433 Elsevier, New York.
30. Orzack M.H., Kornetsky C. Attention dysfunction in chronic schizophrenia. Arch Gen Psychiatry. 14:1966;323-331.
31. Rechtshaffen A., Kales A. A Manual of Standardized Terminology, Techniques, and Scoring System for Sleep Stages of Human Subjects. 1968;US Government Printing Office, Washington, DC.
32. Revah F., Bertranrd D., Galzi J.L., Deviller-Thiery A., Mulle C., Hussy N., et al. Mutations in the channel domain alter desensitization of a neuronal nicotinic receptor. Nature. 353:1991;846-849.
33. Sakman B., Patlak J., Neher E. Single acetylcholine-activated channels show burst kinetics in presence of desensitizing concentrations of agonist. Nature. 286:1980;71-73.
34. Searle S.R., Casella G., McCulloch C.E. Variance Components. 1992;John Wiley & Sons, New York.
35. Seguela P., Wadiche I., Dineley-Miller K., Dani J., Patrick J.W. Molecular cloning, functional properties, and distribution of rat brain alpha7 A nicotinic channel highly permeable to calcium . J Neurosci. 13:1993;596-604.
36. Smith D.A., Boutros N.N., Schwarzkopf S.B. Reliability of P50 auditory event-related potential indices of sensory gating. Psychophysiology. 31:1994;495-502.
37. Straumanis J.J., Shagass C., Roemer R.A. Influence of antipsychotic and antidepressant drugs on evoked potential correlates of psychosis. Biol Psychiatry. 17:1982;1101-1122.
38. Vinogradov S., Solomon S., Ober B.A., Biggins C.A., Shenaut G.K., Fein G. Do semantic priming effects correlate with sensory gating in schizophrenia? Biol Psychiatry. 39:1996;821-824.
39. Waldo M., Gerhardt G., Baker N., Drebing C., Cawthra E., Freedman R. Auditory sensory gating and catecholamine metabolism in schizophrenic and normal subjects. Psychiatry Res. 44:1991;21-32.