Metabolic activity is increased in discrete brain regions before the occurrence of spike-and-wave discharges in weanling rats with genetic absence epilepsy

Developmental Brain Research

Volumn 108, Issue 1-2, 1998, Pages 69-75

  Nehlig, Astrid ^a   Vergnes, Marguerite ^a   Boyet, Sylvette ^a   Marescaux, Christian ^a  

^a INSERM   (France)

Author keywords

2 Deoxyglucose; Absence epilepsy; Cerebral glucose utilization; Development

Indexed keywords

ANIMAL EXPERIMENT; ARTICLE; BRAIN DEVELOPMENT; BRAIN METABOLISM; BRAIN REGION; CONTROLLED STUDY; EPILEPSY; GLUCOSE BRAIN LEVEL; GLUCOSE UTILIZATION; NONHUMAN; PRIORITY JOURNAL; RAT; SPIKE WAVE;

ANIMALS; BLOOD GAS ANALYSIS; BODY TEMPERATURE; BRAIN; CARBON RADIOISOTOPES; DEOXYGLUCOSE; DISEASE MODELS, ANIMAL; ELECTROCARDIOGRAPHY; EPILEPSY, ABSENCE; GLUCOSE; RATS; RATS, MUTANT STRAINS; RATS, WISTAR; WEANING;

EID: 0032527039     PISSN: 01653806     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-3806(98)00031-5     Document Type: Article

References (36)

1. Clifford D.B., Olney J.W., Maniotis A., Collins R.C., Zorumski C.F. The functional anatomy and pathology of lithium-pilocarpine and high-dose pilocarpine seizures. Neuroscience. 23:1987;953-968.
2. Depaulis A., Vergnes M., Liu Z., Kempf E., Marescaux C. Involvement of the nigral output pathways in the inhibitory control of the substantia nigra over generalized non-convulsive seizures in the rat. Neuroscience. 39:1990;339-349.
3. Depaulis A., Vergnes M., Marescaux C. Endogenous control of epilepsy: the nigral inhibitory system. Prog. Neurobiol. 42:1994;33-52.
4. Deza L., Eidelberg E. Development of cortical electrical activity in the rat. Exp. Neurol. 17:1967;425-438.
5. El Hamdi G., Pereira de Vasconcelos A., Vert P., Nehlig A. An experimental model of generalized seizures for the measurement of local cerebral glucose utilization in the immature rat: I. Behavioral characterization and determination of lumped constant. Dev. Brain Res. 69:1992;233-242.
6. Engel J. Jr., Kuhl D.E., Phelps M.E. Patterns of human cerebral glucose metabolism during epileptic seizures. Science. 218:1982;64-66.
7. Engel J. Jr., Lubens P., Kuhl D.E., Phelps M.E. Local cerebral metabolic rate for glucose during petit mal absences. Ann. Neurol. 17:1985;121-128.
8. Franck J.E., Ginter K.L., Schwartzkroin P.A. Developing genetically epilepsy-prone rats have an abnormal seizure response to flurothyl. Epilepsia. 30:1989;1-9.
9. Gale K. Mechanism of seizure control mediated by gamma-aminobutyric acid: role of the substantia nigra. Fed. Proc. 44:1985;2414-2424.
10. K. Gale, R.A. Browning, Anatomical and neurochemical substrates of clonic and tonic seizures, in: M.A. Dichter (Ed.), Mechanisms of Epileptogenesis. The Transition to Seizures, Plenum, New York, 1988, pp. 111-152.
11. Garant D.S., Gale K. Substantia nigra-mediated anticonvulsant actions: role of nigral output pathways. Exp. Neurol. 97:1987;143-159.
12. 14C-2-deoxyglucose study in the lithium-pilocarpine model in rat. Neuroscience. 64:1995;1057-1073.
13. Hirsch E., Danober L., Simler S., Pereira de Vasconcelos A., Maton B., Nehlig A., Marescaux C., Vergnes M. The amygdala is critical for seizure propagation from brainstem to forebrain. Neuroscience. 77:1997;975-984.
14. Le Gal La Salle G., Feldblum S. Role of the amygdala in development of hippocampal kindling in the rat. Exp. Neurol. 82:1983;447-455.
15. P. Loiseau, Childhood absence epilepsy, in: J. Roger, M. Bureau, C. Dravet, F.E. Dreifuss, A. Perret, P. Wolf (Eds.), Epileptic Syndromes in Infancy, Childhood and Adolescence, 2nd edn., John Libbey, London, 1982, pp. 135-150.
16. E.W. Lothman, J.L. Stringer, E.H. Bertram, The dentate gyrus as a control point for seizures in the hippocampus and beyond, in: C.E. Ribak, C.M. Gall, I. Mody, (Eds.), The Dentate Gyrus and its Role in Seizures, Epilepsy Res., Suppl. 7, Elsevier, Amsterdam, 1992, pp. 301-313.
17. Marescaux C., Micheletti G., Vergnes M., Depaulis A., Rumbach L., Warter J.M. A model of chronic spontaneous petit mal-like seizures in the rat: comparison with pentylenetetrazol-induced seizures. Epilepsia. 25:1984;326-331.
18. Marescaux C., Vergnes M., Depaulis A. Genetic absence epilepsy in rats from Strasbourg: a review. J. Neural Transm. Suppl. 35:1992;179-188.
19. McIntyre D.C., Plant J.R. Pyriform cortex involvement in kindling. Neurosci. Biobehav. Rev. 13:1989;277-280.
20. Nehlig A., Pereira de Vasconcelos A., Boyet S. Measurement of local cerebral glucose utilization in freely moving rats during postnatal development. J. Neurosci. 8:1988;2321-2333.
21. Nehlig A., Vergnes M., Marescaux C., Boyet S., Lannes B. Local cerebral glucose utilization in rats with petit mal-like seizures. Ann. Neurol. 29:1991;72-77.
22. Nehlig A., Vergnes M., Marescaux C., Boyet S. Mapping of cerebral energy metabolism in rats with genetic generalized non-convulsive epilepsy. J. Neural Transm. Suppl. 35:1992;141-153.
23. Nehlig A., Vergnes M., Marescaux C., Boyet S. Cerebral energy metabolism in rats with genetic absence epilepsy is not correlated with the pharmacological increase or suppression of spike-wave discharges. Brain Res. 618:1993;1-8.
24. Nehlig A., Vergnes M., Waydelich R., Hirsch E., Charbonné R., Marescaux C., Seylaz J. Absence seizures induce a decrease in cerebral blood flow: human and animal data. J. Cereb. Blood Flow Metab. 16:1996;147-155.
25. Racine R.J., Mosher M., Kairiss E.W. The role of pyriform cortex in the generation of interictal spikes in the kindled preparation. Brain Res. 556:1988;251-263.
26. Roger C., Koziel V., Vert P., Nehlig A. Effects of bilirubin on local cerebral glucose utilization in the immature rat. Dev. Brain Res. 76:1993;115-130.
27. N.M. Sherwood, P.S. Timiras, A Stereotaxic Atlas of the Developing Rat Brain, University of California Press, Berkeley, 1970.
28. Smith Y., Bolam J.P. Neurons of the substantia nigra reticulata receive a dense GABA-containing input from the globus pallidus in the rat. Brain Res. 493:1989;160-167.
29. 14C]deoxyglucose method for the measurement of local cerebral glucose utilization: theory, procedure and normal values in the conscious and anesthetized albino rat. J. Neurochem. 28:1977;897-916.
30. Suda S., Shinohara M., Miyaoka M., Lucignani G., Kennedy C., Sokoloff L. The lumped constant of the deoxyglucose method in hypoglycemia: effects of moderate hypoglycemia on local cerebral glucose utilization. J. Cereb. Blood Flow Metab. 10:1990;499-509.
31. Vergnes M., Marescaux C., Micheletti G., Reis J., Depaulis A., Rumbach L., Warter J.M. Spontaneous paroxysmal electroclinical patterns in rat: a model of generalized non-convulsive epilepsy. Neurosci. Lett. 33:1982;97-101.
32. Vergnes M., Marescaux C., Depaulis A., Micheletti G., Warter J.M. Ontogeny of spontaneous petit mal-like seizures in Wistar rats. Dev. Brain Res. 30:1986;85-87.
33. Vergnes M., Marescaux C., Depaulis A., Micheletti G., Warter J.M. Spontaneous spike-and-wave discharges in thalamus and cortex in a rat model of genetic petit mal-like seizures. Exp. Neurol. 96:1987;127-136.
34. Vergnes M., Marescaux C., Depaulis A. Mapping of spontaneous spike-and-wave discharges in Wistar rats with genetic generalized non-convulsive epilepsy. Brain Res. 523:1990;87-91.
35. M. Vergnes, C. Marescaux, Pathophysiological mechanisms underlying genetic absence epilepsy in rats, in: A. Malafosse, P. Genton, E. Hirsch, C. Marescaux, D. Broglin, R. Bernasconi (Eds.), Idiopathic Generalized Epilepsies: Clinical, Experimental and Genetic Aspects, John Libbey, London, 1994, pp. 151-168.
36. Yoshii N., Tsukajima K. Normal EEG and its development in the white rat. Jpn. J. Physiol. 2:1951;24-38.