Adjuvant efficacy of gelatin particles and microparticles

International Journal of Pharmaceutics

Volumn 168, Issue 2, 1998, Pages 153-161

  Franz, J ^a   Pokorova D ^a   Hampl, J ^a   Dittrich, M ^b  

^a VETERINARY RESEARCH INSTITUTE   (Czech Republic)

^b Charles University in Prague Faculty of Pharmacy   (Czech Republic)

Author keywords

Antibodies; Antigen release; Bovine serum albumin; Gelatin microparticles; Immunization; Rabbits

Indexed keywords

ALUMINUM HYDROXIDE; ALUXID; BOVINE SERUM ALBUMIN; GELATIN; LIPOPOLYSACCHARIDE; MURAMYL DIPEPTIDE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIBODY RESPONSE; ARTICLE; CONTROLLED STUDY; DRUG RELEASE; DYNAMICS; ENCAPSULATION; IMMUNIZATION; IN VITRO STUDY; MICROENCAPSULATION; NONHUMAN; ORAL DRUG ADMINISTRATION; PARTICLE SIZE; PRIORITY JOURNAL; RABBIT; SUBCUTANEOUS DRUG ADMINISTRATION; TECHNIQUE;

EID: 0032526818     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-5173(98)00069-6     Document Type: Article

References (34)

1. Cahill E.S., O'Hagan D.T., Illum L., Barnard A., Mills K.H.G., Redhead K. Immune response and protection against Bordetella pertussis infection after intranasal immunization of mice with filamentous haemagglutinin in solution or incorporated in biodegradable microparticles. Vaccine. 13:1995;455-462.
2. Challacombe S.J., Rahman D., Jeffery H., Davis S.S., O'Hagan D.T. Enhanced secretory IgA and systemic IgG antibody responses after oral immunization with biodegradable microparticles containing antigen. Immunology. 76:1992;164-168.
3. Chandrasekhar U., Sinha S., Bhagat H.R., Sinha V.B., Srivastava B.S. Comparative efficacy of biodegradable liposomes and microspheres as carriers for delivery of Vibrio cholerae antigens in the intestine. Vaccine. 12:1994;1384-1388.
4. Cleland J.L., Powell M.F., Lim A., Barron L., Berman P.W., Eastman D.J., Nunberg J.H., Wrin T., Vennari J.C. Development of a single-shot subunit vaccine for HIV-1. AIDS Res. Hum. Retroviruses. 10:1994;21-26.
5. Cox J.C., Coulter A.R. Adjuvans - a clasification and review of their modes of action. Vaccine. 15:1997;248-256.
6. Damgé C., Aprahamian M., Marchais H., Benoit J.P., Pinget M. Intestinal absorption of PLAGA microspheres in the rat. J. Anat. 189:1996;491-501.
7. Di Silvio L., Gurav N., Kayser M.V., Braden M., Downes S. Biodegradable microspheres: a new delivery system for growth hormone. Biomaterials. 15:1994;931-936.
8. Eldridge J.H., Gilley R.M., Staas J.K., Moldoveanu Z., Meulbroek J.A., Tice T.R. Biodegradable microspheres: vaccine delivery systems for oral immunization. Curr. Top. Microbiol. Immunol. 146:1989;59-66.
9. Eldridge J.H., Hammond C.J., Meulbroek J.A., Staas J.K., Gilley R.M., Tice T.R. Controlled vaccine release in the gut-associated lymphoid tissues. I. Orally administred biodegradable microspheres target the Peyer's patches. J. Control. Release. 11:1990;205-214.
10. Eldridge J.H., Staas J.K., Meulbroek J.A., Tice T.R., Gilley R.M. Biodegradable and biocompatible poly (DL-lactide-co-glycolide) microspheres as an adjuvant for Staphylococcal enterotoxin B toxoid which enhanced the level of toxin-neutralizing antibodies. Infect. Immun. 59:1991;2978-2986.
11. Esposito E., Cortesi R., Nastruzzi C. Gelatin microspheres: influence of preparation parameters and thermal treatment on chemico-physical and biopharmaceutical properties. Biomaterials. 17:1996;2009-2020.
12. Florence A.T. The oral absorption of micro- and nanoparticulates: neither exceptional nor unusual. Pharm. Res. 14:1997;259-266.
13. Gander B., Thomasin C., Merkle H.P., Men Y., Corradin G. Pulsed tetanus toxoid release from PLGA-microspheres and its relevance for immunogenicity in mice. Proc. Int. Symp. Control. Rel. Bioact. Mater. 20:1993;65-71.
14. Gregoriadis G. Immunological adjuvants: a role for liposomes. Immunol. Today. 11:1990;89-97.
15. Hampl J., Dittrich M., Franz J., Reschová S., Stepánek J. Adjuvant activity of linear aliphatic polyester and branched aliphatic oligoester microspheres. Int. J. Pharm. 144:1996;107-114.
16. Hampl, J., Franz, J., Stepánek, J., Toman, M., 1996b. Enhancement of antibody response to bovine herpesvirus 1 with non-specific immunostimulants. Vet. Med.-Czech. 143-147.
17. Lou Y., Groves M.J. The use of gelatin microparticles to delay the release of readily water-soluble materials. J. Pharm. Pharmacol. 47:1995;97-102.
18. McGhee J.R., Mestecky J., Dertzbaugh M.T., Eldridge J.H., Hirasawa M., Kiyono H. The mucosal immune system: from fundamental concepts to vaccine development. Vaccine. 10:1992;75-88.
19. Men Y., Thomasin C., Merkle H.P., Gander B., Corrain G. A single administration of tetanus toxoid in biodegradable microspheres elicits T cell and antibody responses similar or superior to those obtained with aluminium hydroxide. Vaccine. 13:1995;683-689.
20. Morein B., Sundquist B., Hoglund S., Dalsgaard K., Osterhaus A. ISCOM, a novel structure for antigenic presentation of membrane proteins from eneveloped viruses. Nature. 308:1984;457-460.
21. Morein B., Villacres-Eriksson M., Sjölander A., Lövgren Bengtsson K. Novel adjuvants and vaccine delivery system. Vet. Immunol. Immunopathol. 54:1997;373-384.
22. Nakaoka R., Tabata Y., Ikada Y. Potentiality of gelatin microspheres as immunological adjuvant. Vaccine. 13:1995;653-661.
23. O'Hagan D.T., Rahman D., McGee J.P., Jeffery H., Davies M.C., Williams P., Davis S.S., Challacombe S.J. Biodegradable microparticles as controlled release antigen delivery systems. Immunology. 73:1991;239-242.
24. Okada H., Toguchi H. Biodegradable microspheres in drug delivery. Crit. Rev. Ther. Drug Carrier Syst. 12:1995;1-99.
25. Öner L., Groves M.J. Optimization of condition for preparing 2- to 5-micron-range gelatin microparticles by using chilled dehydration agents. Pharm. Res. 10:1993;621-626.
26. Reid G. Soluble proteins incorporate into ISCOMs after covalent attachment of fatty acid. Vaccine. 10:1992;597-602.
27. Sah H., Toddywala R., Chien Y.W. Continuous release of proteins from biodegradable microcapsules and in vivo evaluation of their potential as a vaccine adjuvant. J. Control. Release. 35:1995;137-144.
28. Tabata Y., Ikada Y. Synthesis of gelatin microspheres containing interferon. Pharm. Res. 6:1989;422-427.
29. Tabata Y., Ikada Y. Macrophage activation for antitumor function by muramyl dipeptide-protein conjugates. J. Pharm. Pharmacol. 42:1990;13-19.
30. Tabata Y., Inoue Y., Ikada Y. Size effect on systemic and mucosal immune response induced by oral administration of biodegradable microspheres. Vaccine. 14:1996;1677-1685.
31. Tanaka T., Takino S., Utsumi I. A new gelatinized sustained release dosage form. J. Pharm. Sci. 52:1963;664-667.
32. Toman M., Turánek J., Horavová P. Nonspecific stimulation of resistence of mice to infection by lipopolysacharide of Bordetella bronchiseptica into liposome. Acta Vet. 63:1994;71-79.
33. Uchida T., Martin S., Foster T.P., Wardley R.C., Grimm S. Dose and load studies for subcutaneous and oral delivery of poly(lactide-co-glycolide) microspheres containing ovalbumin. Pharm. Res. 11:1994;1009-1015.
34. Westphal O., Luderitz O., Bister F. Über die Extraktion von Bakterien mit Phenol/Wasser. Z. Naturforsch. 78:1952;148-155.