Fractional factorial designs for optimizing experimental conditions for Hiestand's Indices of Tableting Performance

Powder Technology

Volumn 97, Issue 2, 1998, Pages 151-159

  Venkatesh, Gopi M ^a   Coleman, Jo Ann N ^a   Wrzosek, Tom J ^a   Duddu, Sarma ^a   Palepu, Nagesh R ^a   Bandyopadhyay, Rebanta ^b   Grant, David J W ^b  

^a GLAXOSMITHKLINE   (United Kingdom)

^b UNIVERSITY OF MINNESOTA   (United States)

Author keywords

Experimental conditions; Fractional factorial designs; Indices Tableting Performance

Indexed keywords

BRITTLENESS; DUCTILITY; HARDNESS; MECHANICAL PROPERTIES; PHYSICAL PROPERTIES; PLASTIC DEFORMATION; POROSITY; TENSILE STRENGTH;

BONDING INDEX; BRITTLE FRACTURE INDEX; FRACTIONAL FACTORIAL DESIGNS; HIESTAND INDICES OF TABLETING PERFORMANCE; STRAIN INDEX;

DRUG PRODUCTS;

CELLULOSE; EXCIPIENT; MICROCRYSTALLINE CELLULOSE; PARACETAMOL;

ARTICLE; DRUG GRANULATION; MEASUREMENT; PHYSICAL CHEMISTRY; STATISTICAL ANALYSIS; TABLET MANUFACTURE;

EID: 0032526047     PISSN: 00325910     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0032-5910(98)00007-2     Document Type: Article

References (8)

1. [1] R.J. Robert, R.C. Rowe, Int. J. Pharm. 36 (1987) 205.
2. [2] E.N. Hiestand, J.M. Bane Jr., E.P. Strzelinski, J. Pharm. Sci. 60 (1971) 758.
3. [3] E.N. Hiestand, J.E. Wells, C.B. Peot, J.F. Ochs, J. Pharm. Sci. 66 (1977) 510.
4. [4] E.N. Hiestand, Pharm. Technol. 13 (1989) 54.
5. [5] E.N. Hiestand, D.P. Smith, Powder Technol. 38 (1984) 145.
6. [6] E.N. Hiestand, D.P. Smith, Int. J. Pharm. 67 (1991) 217.
7. [7] E.N. Hiestand, D.P. Smith, Int. J. Pharm. 67 (1991) 231.
8. [8] G.E. Amidon, in: H.G. Brittain (Ed.), Physical Characterization of Pharmaceutical Solids, Marcel Dekker, New York, 1995.