Neurosteroid action at the GABA(A) receptor in fetal rat forebrain

Developmental Brain Research

Volumn 108, Issue 1-2, 1998, Pages 131-137

  Kellogg, C K ^a   Olson, V G ^a   Pleger, G L ^a  

^a UNIVERSITY OF ROCHESTER   (United States)

Author keywords

3 ,5 THP; Androsterone; Diazepam; GABA mediated chloride uptake; Neural organization

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; NEUROSTEROID; 4 AMINOBUTYRIC ACID; ANDROSTERONE; BENZODIAZEPINE RECEPTOR AFFECTING AGENT; CHLORIDE; DIAZEPAM; ELTANOLONE;

ANIMAL TISSUE; ARTICLE; BRAIN DEVELOPMENT; CHLORIDE TRANSPORT; DRUG RECEPTOR BINDING; FEMALE; FOREBRAIN; NERVE CELL NETWORK; NONHUMAN; PRIORITY JOURNAL; RAT; ANIMAL; CHEMISTRY; DRUG EFFECT; FETUS; MALE; METABOLISM; PHYSIOLOGY; PREGNANCY; SEX DIFFERENCE; SPRAGUE DAWLEY RAT; SYNAPTOSOME;

ANDROSTERONE; ANIMALS; CHLORIDES; DIAZEPAM; FEMALE; FETUS; GABA MODULATORS; GAMMA-AMINOBUTYRIC ACID; MALE; PREGNANCY; PREGNANOLONE; PROSENCEPHALON; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, GABA-A; SEX FACTORS; SYNAPTOSOMES;

EID: 0032525443     PISSN: 01653806     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-3806(98)00042-X     Document Type: Article

References (39)

1. Arnold A.P., Breedlove S.M. Organizational and activational effect of sex steroids on brain and behavior: a reanalysis. Horm. Behav. 19:1985;469-499.
2. Behar T.N., Schaffner A.E., Colton C.A., Somogyi R., Olah Z., Lehel C., Barker J.L. GABA-induced chemokinesis and NGF-induced chemotaxis of embryonic spinal cord neurons. J. Neurosci. 14:1994;29-38.
3. A receptor. Brain Res. 561:1991;157-161.
4. Butikofer E.E., Lichtensteiger W., Schlumpf M. Prenatal exposure to diazepam causes sex-dependent changes of the sympathetic control of rat spleen. Neurotoxicol. Teratol. 15:1993;377-382.
5. Cherbini E., Gaiarsa J.L., Ben-Ari Y. GABA: an excitatory transmitter in early postnatal life. Trends Neurosci. 14:1991;515-519.
6. Choi S.J., Weisberg S.N., Kellogg C.K. Control of endogenous norepinephrine release in the hypothalamus of male rats changes over adolescent development. Dev. Brain Res. 98:1997;134-141.
7. Corbier P., Kerdelhue B., Picon R., Roffi J. Changes in testicular weight and serum gonadotropin and testosterone levels before, during, and after birth in the perinatal rat. Endocrinology. 103:1978;985-1992.
8. Crain S.M., Bornstein M.B. Early onset in inhibitory functions during synaptogenesis in fetal mouse brain cultures. Brain Res. 68:1974;351-357.
9. Gee K.W., Bolger M.B., Brinton R.E., Coirini H., McEwen B.S. Steroid modulation of the chloride ionophore in rat brain: structure-activity requirements, regional dependence and mechanism of action. J. Pharmacol. Exp. Ther. 246:1988;803-812.
10. Guillamon A., Cales J.M., Rodriguez-Zafra M., Perez-Laso C., Caminero A., Izquierdo M.A.P., Segovia S. Effects of perinatal diazepam administration on two sexually dimorphic non-reproductive behaviors. Brain Res. Bull. 25:1991;913-916.
11. Hu X.-J., Ticku M.K. Chronic benzodiazepine agonist treatment produces functional uncoupling of the γ-aminobutyric acid-benzodiazepine receptor ionophore complex in cortical neurons. Mol. Pharmacol. 45:1994;618-625.
12. Kawata M. Roles of steroid hormones and their receptors in structural organization in the nervous system. Neurosci. Res. 34:1995;1-46.
13. C.K. Kellogg, Benzodiazepines and the developing nervous system: laboratory findings and clinical implications, in: I.S. Zagon, T.A. Slotkin (Eds.), Maternal Substance Abuse and the Developing Nervous System, Academic Press, San Diego, 1992, pp. 283-321.
14. A receptor function: influence on adaptive responses, in: P.V. Thadani (Ed.), Biological Mechanisms and Perinatal Exposure to Drugs, NIDA Research Monograph 158, U.S. Dept. of Health and Human Services, 1995, pp. 202-226.
15. Kellogg C.K., Pleger G.P. GABA-stimulated chloride uptake and enhancement by diazepam in synaptoneurosomes from rat brain during prenatal and postnatal development. Dev. Brain Res. 49:1989;87-95.
16. Kellogg C.K., Primus R.J., Bitran D. Sexually dimorphic influence of prenatal exposure to diazepam on behavioral responses to environmental challenge and on γ-aminobutyric acid (GABA)-stimulated chloride uptake in the brain. J. Pharmacol. Exp. Ther. 256:1991;259-265.
17. Lauber M.E., Lichtensteiger W. Ontogeny of 5α-reductase (type 1) messenger ribonucleic acid expression in rat brain: early presence in germinal zones. Endocrinology. 137:1996;2718-2730.
18. A receptor subunit mRNAs in the rat brain: III. Embryonic and postnatal development. J. Neurosci. 12:1992;4151-4172.
19. F.M. Leslie, Neurotransmitters as neurotrophic factors, in: S.E. Loughlin, J.H. Fallon (Eds.), Neurotrophic Factors, Academic Press, San Diego, 1993, pp. 565-598.
20. A receptors mediate trophic effects of GABA on embryonic brainstem monoamine neurons in vitro. J. Neurosci. 17:1997;2420-2428.
21. A receptor heterogeneity: neurophysiological implications. Neuropharmacology. 34:1995;245-254.
22. A receptor. Mechanism of action and physiological significance. Prog. Neurobiol. 38:1992;379-395.
23. Markwell M.K., Haas S.M., Tolbert N.E., Bieber L.L. Protein determinations in membrane and lipoprotein samples: manual and automated procedures. Meth. Enzymol. 72:1981;296-303.
24. Marty S., Berzaghi M.P., Berninger B. Neurotrophins and activity-dependent plasticity of cortical interneurons. Trends Neurosci. 20:1997;198-202.
25. Matt D.W., McDonald G.J. In vitro progesterone and testosterone production by the rat placenta during pregnancy. Endocrinology. 115:1984;741-747.
26. B.S. McEwen, Gonadal steroid influences on brain development and sexual differentiation, in: R. Greep (Ed.), Reproductive Physiology IV, Vol. 27, University Park, Baltimore, 1983, pp. 99-145.
27. Paul S.M., Purdy R.H. Neuroactive steroids. FASEB J. 6:1992;51-663.
28. Primus R.J., Kellogg C.K. Pubertal-related changes influence the development of environment-related social interaction in the male rat. Dev. Psychobiol. 22:1989;633-643.
29. Primus R.J., Kellogg C.K. Gonadal status and pubertal age influence the responsiveness of the benzodiazepine/GABA receptor complex to environmental challenge in male rats. Brain Res. 545:1991;257-264.
30. A receptor regulation in culture: altered allosteric interactions following prolonged exposure to benzodiazepines, barbiturates, and methylxanthines. Mol. Pharmacol. 37:1990;710-719.
31. Rupprecht R., Hauser C.A.E., Trapp T., Holsboer F. Neurosteroids: molecular mechanisms of action and psychopharmacological significance. J. Steroid Biochem. Mol. Biol. 56:1996;163-168.
32. - uptake in rat brain synaptoneurosomes: evidence for rapid desensitization of the GABA receptor-coupled chloride ion channel. Mol. Pharmacol. 30:1996;419-426.
33. Simmons R.D., Kellogg C.K., Miller R.K. Prenatal diazepam exposure in rats: long-lasting, receptor-mediated effects on hypothalamic norepinephrine-containing neurons. Brain Res. 293:1984;73-83.
34. 2+ spikes and waves in embryonic neurons: Signaling systems for differentiation. Trends Neurosci. 17:1994;115-118.
35. A receptor α1, β2, and γ2 subunit mRNAs in the granular and agranular frontal cortex of the rat during pre- and postnatal development. Cereb. Cortex. 3:1995;234-246.
36. Weisz J., Ward I.L. Plasma testosterone and progesterone titers of pregnant rats, their male and female fetuses, and neonatal offspring. Endocrinology. 106:1980;306-316.
37. A receptor diversity. Neuropharmacology. 35:1996;1139-1160.
38. Wolf J.R., Joo F., Kasa P. Modulation by GABA of neuroplasticity in the central and peripheral nervous system. Neurochem. Res. 18:1980;452-461.
39. Yu R., Ticku M.K. Chronic neurosteroid treatment produces functional heterologous uncoupling at the γ-aminobutyric acid type A/benzodiazepine receptor complex in mammalian cortical neurons. Mol. Pharmacol. 47:1995;603-610.