The generation of human γδ T cell repertoires during fetal development

Journal of Immunology

Volumn 160, Issue 12, 1998, Pages 5851-5860

  McVay, Laila D ^a   Jaswal, Sheila S ^a,c   Kennedy, Christine ^a,d   Hayday, Adrian ^b   Carding, Simon R ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b YALE UNIVERSITY   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; DNA SEQUENCE; FETUS; FETUS DEVELOPMENT; FETUS LIVER; FLOW CYTOMETRY; GENE EXPRESSION; GENE REARRANGEMENT; HUMAN; HUMAN TISSUE; INTESTINE; ONTOGENY; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; T LYMPHOCYTE; THYMUS; TISSUE DISTRIBUTION; ANIMAL; DIGESTIVE SYSTEM; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; GENETICS; IMMUNOLOGY; MOUSE; PEPTIDE MAPPING; PHENOTYPE; POLYMERASE CHAIN REACTION; PRENATAL DEVELOPMENT;

LYMPHOCYTE ANTIGEN RECEPTOR; MONOCLONAL ANTIBODY;

ANIMALS; ANTIBODIES, MONOCLONAL; DIGESTIVE SYSTEM; EMBRYONIC AND FETAL DEVELOPMENT; FLOW CYTOMETRY; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENE REARRANGEMENT, DELTA-CHAIN T-CELL ANTIGEN RECEPTOR; HUMANS; MICE; PEPTIDE MAPPING; PHENOTYPE; POLYMERASE CHAIN REACTION; RECEPTORS, ANTIGEN, T-CELL, GAMMA-DELTA; THYMUS GLAND; TRANSCRIPTION, GENETIC;

EID: 0032525334     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (57)

1. McVay, L. D., and S. R. Carding. 1996. Extrathymic origin of human γδ T cells during fetal development. J. Immunol. 157:2873.
2. - γ/δ T cells. J. Exp. Med. 177:425.
3. Sánchez, M. J., J. C. Gutiérrez-Ramos, E. Fernández, E. Leonardo, J. Lozano, C. Martínez-A, and M. L. Toribio. 1993. Putative prethymic T cell precursors within the early human embryonic liver: a molecular and functional analysis. J. Exp. Med. 177:19.
4. WHO-IUIS Nomenclature Sub-Committee on TCR Designation. 1995. Nomenclature for T-cell receptor (TCR) gene segments of the immune system. Immunogenetics 42:451.
5. Spencer, J., P. G. Isaacson, T. C. Diss, and T. T. MacDonald. 1989. Expression of disulfide-linked and non-disulfide-linked forms of the T-cell receptor γ/δ heterodimer in human intestinal intraepithelial lymphocytes. Eur. J. Immunol. 19: 1335.
6. + phenotypes are increased in coeliac disease. J. Immunol. 30:665.
7. Ullrich, R., H. L. Schieferdecker, K. Zeigler, E. O. Reicken, and M. Zeitz. 1990. γ/δ T cells in the human intestine express surface markers of activation and are preferentially located in the epithelium. Cell. Immunol. 128:619.
8. Deusch, K., F. Lülling, K. Reich, M. Classen, H. Wagner, and K. Pfeffer. 1991. A major fraction of human intraepithelial lymphocytes simultaneously expresses the γδ T cell receptor, the CD8 accessory molecule and preferentially uses the Vδ1 gene segment. Eur. J. Immunol. 21:1053.
9. Chowers, Y., W. Holtmeier, J. Harwood, E. Morzycka-Wroblewska, and M. F. Kagnoff. 1994. The Vδ1 receptor repertoire in human small intestine and colon. J. Exp. Med. 180:183.
10. Holtmeier, W., Y. Chowers, A. Lumeng, E. Morzycka-Wroblewska, and M. F. Kagnoff. 1995. The δT cell repertoire in human colon and peripheral blood is oligoclonal irrespective of V region usage. J. Clin. Invest. 96:1108.
11. Balk, S. P., E. C. Ebert, R. L. Blumenthal, F. V. McDermott, K. W. Wuchferpennig, S. B. Landau, and R. S. Blumberg. 1991. Oligoclonal expansion and CD1 recognition by human intestinal intraepithelial lymphocytes. Science 253:1411.
12. Van Kerckhove, C., G. J. Russell, K. Deusch, K. Reich, A. K. Bhan, H. DerSimonian, and M. B. Brenner. 1992. Oligoclonality of human intestinal intraepithelial T cells. J. Exp. Med. 175:57.
13. Blumberg, R. S., C. E. Yockey, G. G. Gross, E. C. Ebert, and S. P. Balk. 1993. Human intestinal intraepithelial T lymphocytes are derived from a limited number of T cell clones that utilize multiple Vβ TCR genes. J. Immunol. 150:5144.
14. Gross, G. G., V. L. Schwarz, C. Stevens, E. C. Ebert, R. S. Blumberg, and S. P. Balk. 1994. Distribution of dominant T cell receptor β chains in human intestinal mucosa. J. Exp. Med. 180:1337.
15. Holtmeier, W., T. Witthoft, A. Hennemann, H. S. Winter, and M. F. Kagnoff. 1997. The TCR-δ repertoire in human intestine undergoes characteristic changes during fetal to adult development. J. Immunol. 158:5632.
16. + intestinal intraepithelial lymphocytes (IEL) and the extrathymic development of IEL. Eur. J. Immunol. 24:1080.
17. + lympho-hematopoietic progenitors develop. J. Exp. Med. 184:1449.
18. Mosely, R. L., and J. R. Klein. 1992. Peripheral engraftment of fetal intestine into athymic mice sponsors T cell development: direct evidence for thymopoietic function of murine small intestine. J. Exp. Med. 176:1365.
19. Poussier, P., H. S. Teh, and M. Julius. 1993. Thymus-independent positive and negative selection of T cells expressing a major histocompatibility complex class I-restricted transgenic T cell receptor α/β in the intestinal epithelium. J. Exp. Med. 176:1947.
20. Rocha, B., H. von Boehmer, D. Guy-Grand. 1992. Selection of intraepithelial lymphocytes with CD8 α/α co-receptors by self-antigen in the murine gut. Proc. Natl. Acad. Sci. USA 89:5336.
21. Poussier, P., P. Edouard, C. Lee, and M. Julius. 1992. Thymus-independent development and negative selection of T cells expressing T cell receptor α/β in the intestinal epithelium: evidence for distinct circulation patterns of gut- and thymus-derived T lymphocytes. J. Exp. Med. 176:187.
22. - early thymocytes. J. Exp. Med. 179:721.
23. Vidal, K., I. Grosjean, J. P. Revillard, C. Gespach, and D. Kaiserlian. 1993. Immortalization of mouse intestinal epithelial cells by the SV40-large T gene. J. Immunol. Methods 166:63.
24. Klein, J. R. 1995. T-lymphopoietic capacity of the mouse intestinal epithelium. Semin. Immunol. 7:291.
25. Streeter, G. L. 1948. Developmental horizons in human embryos: description of age groups XV, XVI, XVII, and XVIII. Contrib. Embryol. Carnegie Inst. 32:133.
26. O'Rahilly, R. 1972. Guide to the staging of human embryos. Anal. Am. 130:556.
27. McVay, L. D., S. R. Carding, K. Bottomly, and A. Hayday. 1991. Regulated expression and structure of T cell receptor γ/δ transcripts in human thymic ontogeny, EMBO J. 10:83.
28. Carding, S. R., S. Kyes, E. J. Jenkinson, R. Kingston, K. Bottomly, J. J. T. Owen, and A. Hayday. 1990. Developmentally regulated fetal thymic and extrathymic T-cell receptor γβ gene expression. Genes Dev. 4:1304.
29. Carding, S. R., J. G. McNamara, M. Pan, and K. Bottomly. 1990. Characterization of γδ T cell clones isolated from human fetal liver and thymus. Eur. J. Immunol. 20:1327.
30. Moore, K. L. 1982. The Developing Human - Clinically Oriented Embryology. W. B. Saunders Company, Philadelphia, Ch. 12, pp. 227-254.
31. Orlic, D., and R. Lev. 1977. An electron microscopic study of intraepithelial lymphocytes in human fetal intestine. Lab. Invest. 37:554.
32. Spencer, J., P. G. Isaacson, J. A. Walker-Smith, and T. T. MacDonald. 1989. Heterogeneity in intraepithelial lymphocyte subpopulations in fetal and post-natal human small intestine. J. Pediatr. Gastroenterol. Nutr. 9:173.
33. MacDonald, T. T., and J. Spencer. 1994. Ontogeny of the gut-associated lymphoid system in man. Acta Paediatr. Suppl. 83;(395):3.
34. + T cells in human fetal tissue. J. Exp. Med. 168:1941.
35. Takihara, Y., D. Tkachuk, E. Michalopoulos, E. Champagne, J. Reimann, M. Minden, and T. W. Mak. 1988. Sequence and organization of the diversity, joining, and constant region genes of the human T-cell δ-chain locus. Proc. Natl. Acad. Sci. USA 85:6097.
36. Takihara, Y., J. Reimann, E. Michalopoulos, E. Ciccone, L. Moretta, and T. Mak. 1989. Diversity and structure of human T cell receptor δ chain genes in peripheral blood γ/δ-bearing T lymphocytes. J. Exp. Med. 169:393.
37. Klein, M. H., P. Concannon, M. Everett, L. D. H. Kim, T. Hunkapillar, and L. Hood. 1987. Diversity and structure of human T-cell receptor α-chain variable region genes. Proc. Natl. Acad. Sci. USA 84:6884.
38. Wright, J. A., L. Hood, and P. Concannon. 1991. Human T-cell receptor Vα gene polymorphism. Hum. Immunol. 32:277.
39. Schatz, D. G., M. A. Oettinger, and D. Baltimore. 1989. The V(D)J recombination activating gene, RAG-1. Cell 59:1035.
40. Oettinger, M. A., D. G. Schatz, C. Gorka, and D. Baltimore. 1990. RAG-1 and RAG-2, adjacent genes that synergistically activate V(D)J recombination. Science 248:1517.
41. + peripheral lymphocytes. Eur. J. Immunol. 18:2021.
42. + clones from thymus and peripheral blood. J. Exp. Med. 170:1521.
43. Bottino, C., G. Tambussi, S. Ferrini, E. Ciccone, P. Varese, M. C. Mingari, L. Moretta, and A. Moretta. 1988. Two subsets of human T lymphocytes expressing γ/δ antigen receptor are identifiable by monoclonal antibodies directed to distinct molecular forms of the receptor. J. Exp. Med. 168:491.
44. Borst, J., J. J. M. van Dongen, R. L. H. Bolhuis, P. J. Peters, D. A. Hafler, E. de Vries, and R. J. van de Griend. 1988. Distinct molecular forms of human T cell receptor γ/δ detected on viable T cells by a monoclonal antibody. J. Exp. Med. 167:1625.
45. Bodger, M. P., G. Janossy, F. J. Bollum, G. D. Burford, and V. Hoffbrand. 1983. The ontogeny of terminal deoxytidyl transferase positive cells in the human fetus. Blood 6:1125.
46. Mincheva-Nilsson, L., M. Kling, S. Hammarström, O. Nagaeva, K.-G. Sundqvist, M.-L. Hammarström, and V. Baranov. 1997. γδT cells of human early pregnancy decidua: evidence for local proliferation, phenotypic heterogeneity, and extrathymic differentiation. J. Immunol. 159:3266.
47. 7 integrin. Nature 372:190.
48. +, and memory T cells to fibroblasts. J. Immunol. 152:4912.
49. McVay, L. D., B. Li, R. Biancaniello, M. A. Creighton, D. Bachwich, G. Lichtenstein, J. L. Rombeau, and S. R. Carding. 1997. Changes in human mucosal γδ T cell repertoire and function associated with the disease process in inflammatory bowel disease. Mol. Med. 3:183.
50. Davodeau, F., M. A. Peyrat, M. M. Hallet, I. Houde, H. Vie, and M. Bonneville. 1993. Peripheral selection of antigen receptor junctional features in a major human γδ subset. Eur. J. Immunol. 23:804.
51. Migone, N., S. Padovan, C. Zappador, C. Giachino, M. Bottaro, G. Matullo, C. Carbonara, G. De Libero, and G. Casorati. 1995. Restriction of the T-cell receptor V delta gene repertoire is due to preferential gene rearrangement and is independent of antigen selection. Immunogenetics 42:323.
52. Parker, C. M., V. Groh, H. Band, S. Porcelli, C. Morita, M. Fabbi, D. Class, J. L. Strominger, and M. Brenner. 1990. Evidence for extrathymic changes in the T cell receptor γδ repertoire. J. Exp. Med. 171:1597.
53. Borst, J., A. Wicherink, J. J. M. van Dongen, J. E. de Vries, W. H. Comans-Bitter, F. Wassenaar, and P. van den Elsen. 1989. Non-random expression of T-cell receptor γ and δ variable gene segments in functional T lymphocyte clones from human peripheral blood. Eur. J. Immunol. 19:1559.
54. Scott, S., F. Pandolfi, and J. T. Kurnick. 1990. Fibroblasts mediate T cell survival: a proposed mechanism for retention of primed T cells. J. Exp. Med. 172:1873.
55. Umesaki, Y., H. Setoyama, S. Matsuomo, Y. Okada. 1993. Expansion of alpha beta T-cell receptor-bearing intestinal intraepithelial lymphocytes after microbial colonization in germ-free mice and its independence from the thymus. Immunology 79:32.
56. Kersten, C. M., R. T. McCluskey, L. A. Boyle, and J. T. Kurnick. 1996. Escherichia coli and Pseudomonas aeruginosa induce expansion of Vδ2 cells in adult peripheral blood, but of Vδ1 cells in cord blood. J. Immunol. 157:1613.
57. Krangel, M. S., H. Yssel, C. Brockelhurst, and H. Spits. 1990. A distinct wave of human γδ T lymphocytes in the early fetal thymus: evidence for controlled gene rearrangement and cytokine production. J. Exp. Med. 172:847.