Modulation of glutamate sensitivities by inhibitors of a protein kinase and a protein phosphatase in cultured rat Purkinje cells

Neuroscience Letters

Volumn 247, Issue 2-3, 1998, Pages 139-142

  Kasahara, Jiro ^a   Sugiyama, Hiroyuki ^a  

^a KYUSHU UNIVERSITY   (Japan)

Author keywords

Cerebellum; Glutamate receptor; Long term depression; Long term potentiation; Metabotropic glutamate receptor; Protein kinase; Protein phosphatase; Purkinje cell

Indexed keywords

GLUTAMATE RECEPTOR; GLUTAMIC ACID; METABOTROPIC RECEPTOR; PHOSPHOPROTEIN PHOSPHATASE; PROTEIN KINASE; PROTEIN KINASE (CALCIUM,CALMODULIN) II;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; ENZYME INHIBITION; LONG TERM POTENTIATION; NERVE CELL EXCITABILITY; NEUROMODULATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PURKINJE CELL; RAT; SIGNAL TRANSDUCTION;

1-(5-ISOQUINOLINESULFONYL)-2-METHYLPIPERAZINE; 6-CYANO-7-NITROQUINOXALINE-2,3-DIONE; ANIMALS; BENZYLAMINES; CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; CELLS, CULTURED; ENZYME INHIBITORS; EXCITATORY AMINO ACID ANTAGONISTS; GLUTAMIC ACID; IONTOPHORESIS; NERVE TISSUE PROTEINS; OXAZOLES; PROTEIN-TYROSINE-PHOSPHATASE; PURKINJE CELLS; RATS; RECEPTORS, AMPA; SULFONAMIDES;

EID: 0032524588     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3940(98)00299-7     Document Type: Article

References (15)

1. Ajima A., Ito M. A unique role of protein phosphatases in cerebellar long-term depression. NeuroReport. 6:1995;297-300.
2. Fischer G. Cultivation of mouse cerebellar cells in serum free, hormonally defined media: survival of neurons. Neurosci. Lett. 28:1982;325-329.
3. 2+/calmodulin kinase-inhibited visual cortex neurons. Curr. Opin. Neurobiol. 3:1992;173-176.
4. Hirano T. Differential pre- and postsynaptic mechanisms for synaptic potentiation and depression between a granule cell and a Purkinje cell in rat cerebellar culture. Synapse. 7:1991;321-323.
5. Ito I., Hidaka H., Sugiyama H. Effects of KN-62, a specific inhibitor of calcium/calmodulin-dependent protein kinase II, on long-term potentiation in the rat hippocampus. Neurosci. Lett. 121:1991;119-121.
6. Ito M., Karachot L. Protein kinases and phosphatase inhibitors mediating long-term desensitization of glutamate receptors in cerebellar Purkinje cells. Neurosci. Res. 14:1992;27-38.
7. Linden D.J. A protein synthesis-dependent late phase of cerebellar long-term depression. Neuron. 17:1996;483-490.
8. Linden D.J., Dawson T.M., Dawson V.L. An evaluation of the nitric oxide/cGMP/cGMP-dependent protein kinase cascade in the induction of cerebellar long-term depression in culture. J. Neurosci. 15:1995;5098-5105.
9. Linden D.J., Dickinson M.H., Smeyne M., Connor J.A. A long-term depression of AMPA currents in cultured cerebellar Purkinje neurons. Neuron. 7:1991;81-89.
10. Mulkey R.M., Herron C.E., Malenka R.C. An essential role for protein phosphatases in hippocampal long-term depression. Science. 261:1993;1051-1055.
11. Nakazawa K., Mikawa S., Hashikawa T., Ito M. Transient and persistent phosphorylation of AMPA-type glutamate receptor subunits in cerebellar Purkinje cells. Neuron. 15:1995;697-709.
12. Roche K.W., Tingley W.G., Huganir R.L. Glutamate receptor phosphorylation and synaptic plasticity. Curr. Opin. Neurobiol. 4:1994;383-388.
13. 2+/calmodulin dependent protein kinase II inhibitor KN-93 reduces dopamine contents in PC12h cells. Biochem. Biophys. Res. Commun. 181:1991;968-975.
14. 2+/calmodulin-dependent protein kinase II. J. Biol. Chem. 265:1990;4315-4320.
15. Torii N., Kamishita T., Otsu Y., Tsumoto T. An inhibitor for calcineurin, FK506, blocks induction of long-term depression in rat visual cortex. Neurosci. Lett. 185:1995;1-4.