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Volumn 101, Issue 8, 1998, Pages 1765-1774

Expression of the human histocompatibility leukocyte antigen DR3 transgene reduces the severity of demyelination in a murine model of multiple sclerosis

Author keywords

Demyelination; Theiler's virus

Indexed keywords

GAMMA INTERFERON; HLA DR3 ANTIGEN; INTERLEUKIN 4;

EID: 0032522979     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI167     Document Type: Article
Times cited : (14)

References (50)
  • 1
    • 0026521690 scopus 로고
    • The immunogenetic background of scleroderma - An overview
    • Black, C., D. Briggs, and K. Welsh. 1992. The immunogenetic background of scleroderma - an overview. Clin. Exp. Dermatol. 17:73-78.
    • (1992) Clin. Exp. Dermatol. , vol.17 , pp. 73-78
    • Black, C.1    Briggs, D.2    Welsh, K.3
  • 3
    • 0029987134 scopus 로고    scopus 로고
    • Immune response of HLA-DQ8 transgenic mice to peptides from the third hyper-variable region of HLA-DRB1 correlates with predisposition to rheumatoid arthritis
    • Zanelli, E., C.J. Krco, J.M. Baisch, S. Cheng, and C.S. David. 1996. Immune response of HLA-DQ8 transgenic mice to peptides from the third hyper-variable region of HLA-DRB1 correlates with predisposition to rheumatoid arthritis. Proc. Natl. Acad. Sci. USA. 93:1814-1819.
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 1814-1819
    • Zanelli, E.1    Krco, C.J.2    Baisch, J.M.3    Cheng, S.4    David, C.S.5
  • 4
    • 0028997241 scopus 로고
    • Could HLA-DRB1 be the protective locus in rheumatoid arthritis?
    • Zanelli, E., M.A. Gonzalez-Gay, and C.S. David. 1995. Could HLA-DRB1 be the protective locus in rheumatoid arthritis? Immunol. Today. 16: 274-278.
    • (1995) Immunol. Today , vol.16 , pp. 274-278
    • Zanelli, E.1    Gonzalez-Gay, M.A.2    David, C.S.3
  • 5
    • 0025148180 scopus 로고
    • A single dose of the MHC-linked susceptibility determinant associated with the RT1u haplotype is permissive for insulin-dependent diabetes mellitus in the BB rat
    • Fuks, A., S.J. Ono, E. Colle, and R.D. Guttmann. 1990. A single dose of the MHC-linked susceptibility determinant associated with the RT1u haplotype is permissive for insulin-dependent diabetes mellitus in the BB rat. Exp. Clin. Immunogenet. 7:162-169.
    • (1990) Exp. Clin. Immunogenet. , vol.7 , pp. 162-169
    • Fuks, A.1    Ono, S.J.2    Colle, E.3    Guttmann, R.D.4
  • 6
    • 0022617968 scopus 로고
    • The role of HLA antigens in the manifestation and course of Graves' disease
    • Stenszky, V., L. Kozma, C. Balazs, J.C. Bear, and N.R. Farid. 1986. The role of HLA antigens in the manifestation and course of Graves' disease. Mol. Biol. Med. 3:53-62.
    • (1986) Mol. Biol. Med. , vol.3 , pp. 53-62
    • Stenszky, V.1    Kozma, L.2    Balazs, C.3    Bear, J.C.4    Farid, N.R.5
  • 8
    • 0024596021 scopus 로고    scopus 로고
    • H-2-linked genes influence the severity of herpes simplex virus infection of the peripheral nervous system
    • Simmons, A. H-2-linked genes influence the severity of herpes simplex virus infection of the peripheral nervous system. J. Exp. Med. 169:1503-1507.
    • J. Exp. Med. , vol.169 , pp. 1503-1507
    • Simmons, A.1
  • 9
    • 0022569618 scopus 로고
    • Variations in the susceptibility of Coxsackievirus B3-induced myocarditis among different strains of mice
    • Wolfgram, L.J., K.W. Beisel, A. Herskowitz, and N.R. Rose. 1986. Variations in the susceptibility of Coxsackievirus B3-induced myocarditis among different strains of mice. J. Immunol. 136:1846-1852.
    • (1986) J. Immunol. , vol.136 , pp. 1846-1852
    • Wolfgram, L.J.1    Beisel, K.W.2    Herskowitz, A.3    Rose, N.R.4
  • 10
    • 0015492877 scopus 로고
    • HLA antigens and multiple sclerosis
    • Jersild, C., A. Svejgaard, and T. Fog. 1972. HLA antigens and multiple sclerosis. Lancet. i:1240-1242.
    • (1972) Lancet , vol.1 , pp. 1240-1242
    • Jersild, C.1    Svejgaard, A.2    Fog, T.3
  • 12
    • 0009573338 scopus 로고    scopus 로고
    • A complete genomic screen for multiple sclerosis underscores a role for the major histocompatibility complex
    • Multiple Sclerosis Study Group. 1996. A complete genomic screen for multiple sclerosis underscores a role for the major histocompatibility complex. Nat. Genet. 13:469-471.
    • (1996) Nat. Genet. , vol.13 , pp. 469-471
  • 14
    • 0027978692 scopus 로고
    • Association studies in multiple sclerosis
    • Ebers, G.C., and A.D. Sadovnick. 1994. Association studies in multiple sclerosis. J. Neuroimmunol. 53:117-122.
    • (1994) J. Neuroimmunol. , vol.53 , pp. 117-122
    • Ebers, G.C.1    Sadovnick, A.D.2
  • 15
    • 0021813747 scopus 로고
    • Clinical sub-groups of multiple sclerosis in relation to HLA: DR alleles as possible markers of disease progression
    • Duquette, P., F. Decary, J. Pleines, D. Boivin, G. Lamoureux, J.B. Cosgrove, and Y. Lapierre. 1985. Clinical sub-groups of multiple sclerosis in relation to HLA: DR alleles as possible markers of disease progression. Can. J. Neurol. Sci. 12:106-110.
    • (1985) Can. J. Neurol. Sci. , vol.12 , pp. 106-110
    • Duquette, P.1    Decary, F.2    Pleines, J.3    Boivin, D.4    Lamoureux, G.5    Cosgrove, J.B.6    Lapierre, Y.7
  • 16
    • 0019941576 scopus 로고
    • HLA and heterogeneity of multiple sclerosis
    • Engell, T., N.E. Raun, M. Thomsen, and P. Platz. 1982. HLA and heterogeneity of multiple sclerosis. Neurology. 32:1043-1046.
    • (1982) Neurology , vol.32 , pp. 1043-1046
    • Engell, T.1    Raun, N.E.2    Thomsen, M.3    Platz, P.4
  • 18
    • 0023887691 scopus 로고
    • Histocompatibility antigens in multiple sclerosis patients participating in a multicentre trial of azathioprine
    • British and Dutch Multiple Sclerosis Azathioprine Trial Group. 1988. Histocompatibility antigens in multiple sclerosis patients participating in a multicentre trial of azathioprine. J. Neurol. Neurosurg. Psychiatry. 51:412-415.
    • (1988) J. Neurol. Neurosurg. Psychiatry , vol.51 , pp. 412-415
  • 20
    • 0016746673 scopus 로고
    • Theiler's virus infection in mice: An unusual biphasic disease leading to demyelination
    • Lipton, H.L. 1975. Theiler's virus infection in mice: an unusual biphasic disease leading to demyelination. Infect. Immun. 11:1147-1155.
    • (1975) Infect. Immun. , vol.11 , pp. 1147-1155
    • Lipton, H.L.1
  • 21
    • 0022571627 scopus 로고
    • Susceptibility to Theiler's virus-induced demyelination. Mapping of the gene within the H-2D region
    • Rodriguez, M., J.L. Leibowitz, and C.S. David. 1986. Susceptibility to Theiler's virus-induced demyelination. Mapping of the gene within the H-2D region. J. Exp. Med. 163:620-631.
    • (1986) J. Exp. Med. , vol.163 , pp. 620-631
    • Rodriguez, M.1    Leibowitz, J.L.2    David, C.S.3
  • 22
    • 0022386163 scopus 로고
    • Theiler's murine encephalomyelitis virus (TMEV)-induced demyelinating disease is influenced by the H-2D region: Correlation with TMEV-specific delayed-type hypersensitivity
    • Clatch, R.J., R.W. Melvoid, S.D. Miller, and H.L. Lipton. 1985. Theiler's murine encephalomyelitis virus (TMEV)-induced demyelinating disease is influenced by the H-2D region: correlation with TMEV-specific delayed-type hypersensitivity. J. Immunol. 135:1408-1414.
    • (1985) J. Immunol. , vol.135 , pp. 1408-1414
    • Clatch, R.J.1    Melvoid, R.W.2    Miller, S.D.3    Lipton, H.L.4
  • 23
    • 0022393468 scopus 로고
    • Demyelination induced by Theiler's virus: Influence of the H-2 haplotype
    • Rodriguez. M., and C.S. David. 1985. Demyelination induced by Theiler's virus: influence of the H-2 haplotype. J. Immunol. 135:2145-2148.
    • (1985) J. Immunol. , vol.135 , pp. 2145-2148
    • Rodriguez, M.1    David, C.S.2
  • 25
    • 0025051323 scopus 로고
    • Major histocompalibility complex-conferred resistance to Theiler's virus-induced demyelinating disease is inherited as a dominant trait in B10 congenic mice
    • Patick, A.K., L.R. Pease, C.S. David, and M. Rodriguez. 1990. Major histocompalibility complex-conferred resistance to Theiler's virus-induced demyelinating disease is inherited as a dominant trait in B10 congenic mice. J. Virol. 64:5570-5576.
    • (1990) J. Virol. , vol.64 , pp. 5570-5576
    • Patick, A.K.1    Pease, L.R.2    David, C.S.3    Rodriguez, M.4
  • 26
    • 0004718157 scopus 로고
    • The contribution of MHC gene products to demyelination by Theiler's virus
    • C. David, editor. Plenum Publishing Corp., New York
    • Rodriguez, M., C.S. David, and L.R. Pease. 1987. The contribution of MHC gene products to demyelination by Theiler's virus. In Major Histocompatibility Genes and Their Role in Immune Function. C. David, editor. Plenum Publishing Corp., New York. 747-756.
    • (1987) Major Histocompatibility Genes and Their Role in Immune Function , pp. 747-756
    • Rodriguez, M.1    David, C.S.2    Pease, L.R.3
  • 27
    • 0022655687 scopus 로고
    • Partial suppression of Theiler's virus-induced demyelination in vivo by administration of monoclonal antibodies to immune-response gene products (Ia antigens)
    • Rodriguez, M., W.P. Lafuse, J.L. Leibowitz, and C.S. David. 1986. Partial suppression of Theiler's virus-induced demyelination in vivo by administration of monoclonal antibodies to immune-response gene products (Ia antigens). Neurology. 36:964-970.
    • (1986) Neurology , vol.36 , pp. 964-970
    • Rodriguez, M.1    Lafuse, W.P.2    Leibowitz, J.L.3    David, C.S.4
  • 28
    • 0023910268 scopus 로고
    • Successful therapy of TMEV-induced demyelination (DA strain) with monoclonal anti-lyt 2.2 antibody
    • Rodriguez, M., and S. Sriram. 1988. Successful therapy of TMEV-induced demyelination (DA strain) with monoclonal anti-lyt 2.2 antibody. J. Immunol. 140:2950-2955.
    • (1988) J. Immunol. , vol.140 , pp. 2950-2955
    • Rodriguez, M.1    Sriram, S.2
  • 29
    • 0023251015 scopus 로고
    • The effect of L3T4 T cell depletion on the pathogenesis of Theiler's murine encephalomyelitis virus infection in CBA mice
    • Welsh, C.J., P. Tonks, A.A. Nash, and W.F. Blakemore. 1987. The effect of L3T4 T cell depletion on the pathogenesis of Theiler's murine encephalomyelitis virus infection in CBA mice. J. Gen. Virol. 68:1659-1667.
    • (1987) J. Gen. Virol. , vol.68 , pp. 1659-1667
    • Welsh, C.J.1    Tonks, P.2    Nash, A.A.3    Blakemore, W.F.4
  • 30
    • 9044227264 scopus 로고    scopus 로고
    • Theiler's virus persistence and demyelination in major histocompatibility complex class II-deficient mice
    • Njenga, M.K., K.D. Pavelko, J. Baisch, X. Lin, C.S. David, J.L. Leibowitz, and M. Rodriguez. 1996. Theiler's virus persistence and demyelination in major histocompatibility complex class II-deficient mice. J. Virol. 70:1729-1737.
    • (1996) J. Virol. , vol.70 , pp. 1729-1737
    • Njenga, M.K.1    Pavelko, K.D.2    Baisch, J.3    Lin, X.4    David, C.S.5    Leibowitz, J.L.6    Rodriguez, M.7
  • 31
    • 0023234382 scopus 로고
    • Immune response gene products (Ia antigens) on glial and endothelial cells in virus-induced demyelination
    • Rodriguez, M., M.L. Pierce, and E.A. Howie. 1987. Immune response gene products (Ia antigens) on glial and endothelial cells in virus-induced demyelination. J. Immunol. 138:3438-3442.
    • (1987) J. Immunol. , vol.138 , pp. 3438-3442
    • Rodriguez, M.1    Pierce, M.L.2    Howie, E.A.3
  • 32
    • 0028261110 scopus 로고
    • Negative and positive selection by HLA-DR3(DRw17) molecules in transgenic mice
    • Strauss, G., D.A.A. Vignali, G. Schonrich, and G.L. Hammerling. 1994. Negative and positive selection by HLA-DR3(DRw17) molecules in transgenic mice. Immunogenetics. 40:104-108.
    • (1994) Immunogenetics , vol.40 , pp. 104-108
    • Strauss, G.1    Vignali, D.A.A.2    Schonrich, G.3    Hammerling, G.L.4
  • 33
    • 0024506233 scopus 로고
    • Erichrome stain for myelin on osmicated tissue embedded in glycol methacrylate plastic
    • Pierce, M., and M. Rodriguez. 1989. Erichrome stain for myelin on osmicated tissue embedded in glycol methacrylate plastic. J. Histotechnol. 12:35-36.
    • (1989) J. Histotechnol. , vol.12 , pp. 35-36
    • Pierce, M.1    Rodriguez, M.2
  • 34
    • 0021053199 scopus 로고
    • Neonatal infection with the DA strain of Theiler's murine encephalomyelitis virus (TMEV)
    • Rodriguez, M., J.L. Leibowitz, H.C. Powell, and P.W. Lampert. 1984. Neonatal infection with the DA strain of Theiler's murine encephalomyelitis virus (TMEV). Lab. Invest. 49:672-679.
    • (1984) Lab. Invest. , vol.49 , pp. 672-679
    • Rodriguez, M.1    Leibowitz, J.L.2    Powell, H.C.3    Lampert, P.W.4
  • 36
    • 0030033482 scopus 로고    scopus 로고
    • A monoclonal natural autoantibody that promotes remyelination suppresses central nervous system inflammation and increases virus expression after Theiler's virus-induced demyelination
    • Miller, D.J., M.K. Njenga, P.D. Murray, J.L. Leibowitz, and M. Rodriguez. 1996. A monoclonal natural autoantibody that promotes remyelination suppresses central nervous system inflammation and increases virus expression after Theiler's virus-induced demyelination. Int. Immunol. 8:131-141.
    • (1996) Int. Immunol. , vol.8 , pp. 131-141
    • Miller, D.J.1    Njenga, M.K.2    Murray, P.D.3    Leibowitz, J.L.4    Rodriguez, M.5
  • 37
    • 0026566996 scopus 로고
    • Determination of tolerance to self E alpha peptides by clonal elimination of H-2E reactive T cells and antigen presentation by H-2A molecules
    • Krco, C.J., T.G. Beito, and C.S. David. 1992. Determination of tolerance to self E alpha peptides by clonal elimination of H-2E reactive T cells and antigen presentation by H-2A molecules. Transplantation (Baltimore). 54:920-923.
    • (1992) Transplantation (Baltimore) , vol.54 , pp. 920-923
    • Krco, C.J.1    Beito, T.G.2    David, C.S.3
  • 38
    • 0024520598 scopus 로고
    • Characterization of the inflammatory response in the CNS of mice susceptible or resistant to demyelination by Theiler's virus
    • Lindsley, M., and M. Rodriguez. 1989. Characterization of the inflammatory response in the CNS of mice susceptible or resistant to demyelination by Theiler's virus. J. Immunol. 142:2677-2682.
    • (1989) J. Immunol. , vol.142 , pp. 2677-2682
    • Lindsley, M.1    Rodriguez, M.2
  • 39
    • 0025335068 scopus 로고
    • Theiler's virus-induced demyelination in mice immunosuppressed with anti-IgM and in mice expressing the xid gene
    • Rodriguez, M., J.J. Kenny, R.L. Thiemann, and G.E. Woloschak. 1990. Theiler's virus-induced demyelination in mice immunosuppressed with anti-IgM and in mice expressing the xid gene. Microb. Pathg. 8:23-35.
    • (1990) Microb. Pathg. , vol.8 , pp. 23-35
    • Rodriguez, M.1    Kenny, J.J.2    Thiemann, R.L.3    Woloschak, G.E.4
  • 40
    • 0028672769 scopus 로고
    • Influence of deletion of T cell receptor V́ genes on Theiler's virus model of multiple sclerosis
    • Rodriguez, M., G.H. Nabozny, R.L. Thiemann, and C.S. David. 1994. Influence of deletion of T cell receptor V́ genes on Theiler's virus model of multiple sclerosis. Autoimmunity. 19:221-230.
    • (1994) Autoimmunity , vol.19 , pp. 221-230
    • Rodriguez, M.1    Nabozny, G.H.2    Thiemann, R.L.3    David, C.S.4
  • 41
    • 0026513903 scopus 로고
    • Role of T cell receptor Vβ genes in Theiler's virus-induced demyelination of mice
    • Rodriguez, M., A.K. Patick, L.R. Pease, and C.S. David. 1992. Role of T cell receptor Vβ genes in Theiler's virus-induced demyelination of mice. J. Immunol. 148:921-927.
    • (1992) J. Immunol. , vol.148 , pp. 921-927
    • Rodriguez, M.1    Patick, A.K.2    Pease, L.R.3    David, C.S.4
  • 42
    • 0029830079 scopus 로고    scopus 로고
    • HLA-DRB1 polymorphism determines susceptibility to autoimmune thyroiditis in transgenic mice: Definitive association with HLA-DRB1*0301 (DR3) gene
    • Kong, Y.C.M., L.C. Lomo, R.W. Motte, A.A. Giraldo, J. Baisch, G. Strauss, G.J. Hammerling, and C.S. David. 1996. HLA-DRB1 polymorphism determines susceptibility to autoimmune thyroiditis in transgenic mice: definitive association with HLA-DRB1*0301 (DR3) gene. J. Exp. Med. 184:1167-1172.
    • (1996) J. Exp. Med. , vol.184 , pp. 1167-1172
    • Kong, Y.C.M.1    Lomo, L.C.2    Motte, R.W.3    Giraldo, A.A.4    Baisch, J.5    Strauss, G.6    Hammerling, G.J.7    David, C.S.8
  • 45
    • 0028863847 scopus 로고
    • Functions of T-cell subsets and cytokines in mycobacterial infections
    • Munk, M.E., and M. Emoto. 1995. Functions of T-cell subsets and cytokines in mycobacterial infections. Eur. Resp. J. Suppl. 20:668S-675S.
    • (1995) Eur. Resp. J. Suppl. , vol.20
    • Munk, M.E.1    Emoto, M.2
  • 46
    • 0025106262 scopus 로고
    • Inhibition of Theiler's virus-induced demyelination in vivo by tumor necrosis factor alpha
    • Paya, C.V., P.J. Leibson, A.K. Patick, and M. Rodriguez. 1990. Inhibition of Theiler's virus-induced demyelination in vivo by tumor necrosis factor alpha. Im. Immunol. 2:909-913.
    • (1990) Im. Immunol. , vol.2 , pp. 909-913
    • Paya, C.V.1    Leibson, P.J.2    Patick, A.K.3    Rodriguez, M.4
  • 47
    • 0027939355 scopus 로고
    • Recombinant human IL-6 suppresses demyelination in a viral model of multiple sclerosis
    • Rodriguez, M., K.D. Pavelko, C.W. McKinney, and J.L. Leibowitz. 1994. Recombinant human IL-6 suppresses demyelination in a viral model of multiple sclerosis. J. Immunol. 153:3811-3821.
    • (1994) J. Immunol. , vol.153 , pp. 3811-3821
    • Rodriguez, M.1    Pavelko, K.D.2    McKinney, C.W.3    Leibowitz, J.L.4
  • 48
    • 0028670263 scopus 로고
    • Alteration in the level of interferon-gamma results in acceleration of Theiler's virus-induced demyelinating disease
    • Pullen, L.C., S.D. Miller, M.C. Dal Canto, P.M. Van der Meide, and B.S. Kim. 1994. Alteration in the level of interferon-gamma results in acceleration of Theiler's virus-induced demyelinating disease. J. Neuroimmunol. 55:143-152.
    • (1994) J. Neuroimmunol. , vol.55 , pp. 143-152
    • Pullen, L.C.1    Miller, S.D.2    Dal Canto, M.C.3    Van Der Meide, P.M.4    Kim, B.S.5
  • 49
    • 0028212497 scopus 로고
    • Class II-restricted T cell responses in Theiler's murine encephalomyelitis virus-induced demyelinating disease. V. Mapping of a dominant immunopathologic VP2 T cell epitope in susceptible SJL/J mice
    • Gerety, S.J., M.K. Rundell, M.C. Dal Canto, and S.D. Miller. 1994. Class II-restricted T cell responses in Theiler's murine encephalomyelitis virus-induced demyelinating disease. V. Mapping of a dominant immunopathologic VP2 T cell epitope in susceptible SJL/J mice. J. Immunol. 152:908-918.
    • (1994) J. Immunol. , vol.152 , pp. 908-918
    • Gerety, S.J.1    Rundell, M.K.2    Dal Canto, M.C.3    Miller, S.D.4
  • 50
    • 0028295492 scopus 로고
    • Class II-restricted T cell responses in Theiler's murine encephalomyelitis virus-induced demyelinating disease. VI. Potentiation of demyelination with and characterization of an immunopathologic CD4+ T cell line specific for an immunodominant VP2 epilope
    • Gerety, S.J., M.K. Rundell, M.C. Dal Canto, and S.D. Miller. 1994. Class II-restricted T cell responses in Theiler's murine encephalomyelitis virus-induced demyelinating disease. VI. Potentiation of demyelination with and characterization of an immunopathologic CD4+ T cell line specific for an immunodominant VP2 epilope. J. Immunol. 152:919-929.
    • (1994) J. Immunol. , vol.152 , pp. 919-929
    • Gerety, S.J.1    Rundell, M.K.2    Dal Canto, M.C.3    Miller, S.D.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.