Risks associated with conversion of stable patients after liver transplantation to the microemulsion formulation of cyclosporine

Transplantation

Volumn 65, Issue 7, 1998, Pages 995-997

  Freise, Chris E ^a   Galbraith, Cynthia A ^a   Nikolai, Beverly J ^a   Ascher, Nancy L ^a   Lake, John R ^a   Stock, Peter G ^a   Roberts, John P ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOSPORIN; CYCLOSPORIN A;

ARTICLE; CLINICAL TRIAL; DRUG FORMULATION; DRUG SAFETY; HEADACHE; HUMAN; IMMUNOSUPPRESSIVE TREATMENT; LIVER TRANSPLANTATION; MAJOR CLINICAL STUDY; MICROEMULSION; NEUROTOXICITY; PRIORITY JOURNAL;

ADOLESCENT; ADULT; AGED; CHEMISTRY, PHARMACEUTICAL; CYCLOSPORINE; EMULSIONS; FEMALE; HUMANS; IMMUNOSUPPRESSIVE AGENTS; LIVER DISEASES; LIVER TRANSPLANTATION; MALE; MIDDLE AGED; RISK FACTORS;

EID: 0032522762     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/00007890-199804150-00022     Document Type: Article

References (7)

1. Noble S, Markham A. Cyclosporine: a review of the pharmacokinetic properties, clinical efficacy and tolerability of a microemulsion-based formulation (Neoral). Drugs 1995; 50(5): 924.
2. Mueller EA, Kovarik JM, van Bree JB, Tetzloff W, Grevel J, Kutz K. Improved dose linearity of cyclosporine pharmacokinetics from a microemulsion formulation. Pharmacol Res 1994; 11(2): 301.
3. Freeman D, et al. Pharmacokinetics of a new oral formulation of cyclosporine in liver transplant recipients. Ther Drug Monit 1995; 17(3): 213.
4. Mueller EA, Kallay Z, Kovarik JM, et al. Bile-independent absorption of cyclosporine from a microemulsion formulation in liver transplant patients. Transplantation 1995; 60(5): 515.
5. Neumayer HH, et al. Clinical experience transferring kidney transplant patients from Sandimmun to Sandimmun Neoral: results after 3 months. Clin Nephrol 1995; 43 (suppl 1): S27.
6. Wahlberg J, Wilczek HE, Fauchald P, et al. Consistent absorption of cyclosporine from a microemulsion formulation assessed in stable renal transplant recipients over a one-year study period. Transplantation 1995; 60(7): 648.
7. Kovarik JM, Mueller EA, van Bree JB, et al. Cyclosporine pharmacokinetics and variability from a microemulsion formulation: a multicenter investigation in kidney transplant patients. Transplantation 1994; 58(6): 658.