D1/D5 dopamine receptors inhibit depotentiation at CA1 synapses via cAMP-dependent mechanism

Journal of Neuroscience

Volumn 18, Issue 4, 1998, Pages 1270-1279

  Otmakhova, Nonna A ^a   Lisman, John E ^a  

^a BRANDEIS UNIVERSITY   (United States)

Author keywords

Adenylyl cyclase; CA1; cAMP; cAMP dependent protein kinase; D1 D5 dopamine receptors; Depotentiation; Early LTP; Field EPSP; Hippocampus; Learning; adrenoreceptors

Indexed keywords

ADENYLATE CYCLASE; BETA ADRENERGIC RECEPTOR; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; DOPAMINE RECEPTOR; FORSKOLIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; DOPAMINE BRAIN LEVEL; ENZYME ACTIVITY; HIPPOCAMPUS; LEARNING; LONG TERM MEMORY; LONG TERM POTENTIATION; NERVE CELL PLASTICITY; NONHUMAN; PRIORITY JOURNAL; RAT; VISUAL DISCRIMINATION;

EID: 0032519884     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.18-04-01270.1998     Document Type: Article

References (6)

1. 1-linked receptors in rat hippocampus. Neuron 10:83-88.
2. Arai A, Kessler M, Lynch G (1990) The effects of adenosine on the development of long-term potentiation. Neurosci Lett 119:41-44.
3. Barria A, Muller D, Derkach V, Griffith LC, Soderling TR (1997) Regulatory phosphorylation of AMPA-type glutamate receptors by CaM-KII during long-term potentiation [see comments]. Science 276:2042-2045.
4. Bergson C, Mrzljak L, Smiley JF, Pappy M, Levenson R, Goldman-Rakic PS (1995) Regional, cellular, and subcellular variations in the distribution of D1 and D5 dopamine receptors in primate brain. J Neurosci 15:7821-7836.
5. Bernabeu R, Bevilaqua L, Ardenghi P, Bromberg E, Schmitz P, Bianchin M, Izquierdo I, Medina JH (1997) Involvement of hippocampal cAMP/cAMP-dependent protein kinase signaling pathways in a late memory consolidation phase of aversively motivated learning in rats. Proc Natl Acad Sci USA 94:7041-7046.
6. Blitzer RD, Wong T, Nouranifar R, Iyengar R, Landau EM (1995) Postsynaptic cAMP pathway gates early LTP in hippocampal CA1 region. Neuron 15:1403-1414.