A β-3 adrenergic agonist (BRL-37,344) decreases food intake

Physiology and Behavior

Volumn 63, Issue 4, 1998, Pages 723-728

  Tsujii, Satoru ^a   Bray, George A ^b  

^a PENNINGTON BIOMEDICAL RESEARCH CENTER   (United States)

^b UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

Satiety; Zucker rats; 3 adrenergic agonist

Indexed keywords

4 [2 [[2 (3 CHLOROPHENYL) 2 HYDROXYETHYL]AMINO]PROPYL]PHENOXYACETIC ACID; BETA 3 ADRENERGIC RECEPTOR; BETA 3 ADRENERGIC RECEPTOR STIMULATING AGENT; PROPRANOLOL;

ANIMAL EXPERIMENT; ARTICLE; BROWN ADIPOSE TISSUE; CONTROLLED STUDY; DRUG EFFECT; FEMALE; FOOD INTAKE; INJECTION; INTRACEREBROVENTRICULAR DRUG ADMINISTRATION; INTRAPERITONEAL DRUG ADMINISTRATION; NONHUMAN; PRIORITY JOURNAL; RAT; SATIETY;

EID: 0032519741     PISSN: 00319384     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0031-9384(97)00518-0     Document Type: Article

References (45)

1. Arase K., Fisler J. S., Shargill N. S., York D. A., Bray G. A. Intracerebroventricular infusions of 3-hydroxybutyrate and insulin in a rat model of dietary obesity. Am. J. Physiol. 255:1988;R974-R981.
2. 3 and atypical β-adrenoceptors. Med. Res. Rev. 13:1993;663-729.
3. Arch J. R. S., Ainsworth A. T., Cawthorne M. A., Piercy V., Sennitt M. V., Thody V. E., Wilson C., Wilson S. Atypical beta-adrenoceptors on brown adipocytes as targets for anti-obesity drugs. Nature (Lond.). 309:1984;163-165.
4. Atkinson J., Kirchertz E. J., Peters-Haefeli L. Effect of peripheral clonidine on ingestive behavior. Physiol. Behav. 21:1978;73-77.
5. Bray G. A. The nutrient balance hypothesis Peptides, sympathetic activity and food intake . Ann. NY Acad. Sci. 676:1993;223-241.
6. Canfield P., Paraskeva P. β-Adrenoceptor agonist stimulation of acid secretion by rat stomach in vitro is mediated by 'atypical' β-adrenoceptors. Br. J. Pharmacol. 106:1992;583-586.
7. Carpenter R. G., Grossman S. P. Early streptozotocin diabetes and hunger. Physiol. Behav. 31:1983;175-178.
8. Cawthorne M. A., Sennitt M. V., Arch J. R. S., Smith S. A. BRL-35,135, a potent and selective atypical β-adrenoceptor agonist. Am. J. Clin. Nutr. 55:1992;252S-257S.
9. Clouet P., Henninger C., Bezard J. Study of some factors controlling fatty acid oxidation in liver mitochondria of obese Zucker rats. Biochem. J. 239:1986;103-108.
10. 3 adrenergic receptor agonist treatment of diet-induced obesity in mice. Endocrinology. 138:1997;405-413.
11. Connacher A. A., Bennet W. M., Jung R. T. Clinical studies with the β-drenoceptor agonist BRL 26,830A. Am. J. Clin. Nutr. 55:1992;258S-261S.
12. Currie P. J., Wilson L. M. Bi-directional effects of clonidine on carbohydrate intake in genetically obese (ob/ob) mice. Pharmacol. Biochem. Behav. 38:1991;177-184.
13. Emorine, L. J.; Bruno, F.; Pairault, J.; Briend-Sutren, M.; Nahmias, C.; Marullo, S.; Delavier-Klutchko, C; Strosberg D. A. The human β3-adrenergic receptor: relationship with atypical receptors. Am. J. Clin. Nutr. 55:215S-218S; 1992.
14. 3-adrenoceptor mRNA in rat tissues. Br. J. Pharmacol. 117:1996;210-216.
15. Friedman M. I., Ramirez I. Insulin counteracts the satiating effect of a fat meal in rats. Physiol. Behav. 40:1987;655-659.
16. Friedman M. I., Tordoff M. G. Fatty acid oxidation and glucose utilization interact to control food intake in rats. Am. J. Physiol. 251:1986;R840-R845.
17. Friedman M. I., Tordoff M. G., Ramirez I. Integrated metabolic control of food intake. Brain Res. Bull. 17:1986;855-859.
18. Geary N., Grothchel H., Scharrer E. Blood metabolites and feeding during postinsulin hypophagia. Am. J. Physiol. 243:1982;R304-R311.
19. 2-noradrenergic receptors in the paraventricular nucleus mediate feeding induced by norepinephrine and clonidine. Eur. J. Pharmacol. 115:1985;11-19.
20. Grossman S. P. Eating and drinking elicited by direct adrenergic or cholinergic stimulation of hypothalamus. Science (Washington DC). 132:1960;301-302.
21. Grossman S. P. The role of glucose, insulin and glucagon in the regulation of food intake and body weight. Neurosci. Biobehav. Rev. 10:1986;295-315.
22. 3-selective agonist-induced effects on energy expenditure, insulin secretion, and food intake. J. Biol. Chem. 272:17686-17693; 1997.
23. Hamann A., Flier J. S., Lowell B. B. Decreased brown fat markedly enhances susceptibility to diet-induced obesity, diabetes, and hyperlipidemia. Endocrinology. 137:1996;21-29.
24. Harris R. B. S., Martin R. J. Lipostatic theory of energy balance Concepts and signals . Nutr. Behav. 1:1984;253-275.
25. Himms-Hagen J. Role of brown adipose tissue thermogenesis in control of thermoregulatory feeding in rats A new hypothesis that links thermostatic and glucostatic hypotheses for control of food-intake . Proc. Soc. Exp. Biol. Med. 208:1995;159-169.
26. Himms-Hagen J., Cui J., Danforth E. Jr, Taatjes D. J., Lang S. S., Waters B. L., Claus T. H. Effect of CL-316,243, a thermogenic β-3 agonist, on energy balance and brown and white adipose tissues in rats. Am. J. Physiol. 266:1994;R1371-R1382.
27. Leibowitz S. F. Reciprocal hunger-regulating circuits involving alpha- and beta-adrenergic receptors located, respectively, in the ventromedial and lateral hypothalamus. Proc. Natl. Acad. Sci. USA. 67:1970;1063-1070.
28. Leibowitz S. F. Brain monoamines and peptides Role in the control of eating behavior . Fed. Proc. 45:1986;1396-1403.
29. Leibowitz S. F., Jhanwar-Uniyal M., Dvorkin B., Makman M. H. Distribution of α-adrenergic, β-adrenergic and dopaminergic receptors in discrete hypothalamic areas of rat. Brain Res. 233:1982;97-114.
30. Mantzoros C. S., Qu D., Frederich R. C., Susulic V. S., Lowell B. B., Maratos-Flier E., Flier J. S. Activation of β3-adrenergic receptors suppresses leptin expression and mediates a leptin-independent inhibition of food intake in mice. Diabetes. 45:1996;909-914.
31. Mayer J. Regulation of energy intake and the body weight The glucostatic theory and the lipostatic hypothesis . Ann. NY Acad. Sci. 63:1955;15-43.
32. Paxinos G., Watson C. The rat brain in stereotaxic coordinates. 1982;Academic Press, Sydney.
33. Ritter S., Taylor J. S. Vagal sensory neurons are required for lipoprivic but not glucoprivic feeding in rats. Am. J. Physiol. 258:1990;R1395-R1401.
34. Ritter S., Wise C. D., Stein L. Neurochemical regulation of feeding in the rat Facilitation by α-noradrenergic, but not dopaminergic, receptor stimulants . J. Comp. Physiol. Psychol. 88:1975;778-784.
35. Scharrer E., Langhans W. Control of food intake by fatty acid oxidation. Am. J. Physiol. 250:1986;R1003-R1006.
36. Simiand J., Keane P. E., Guitard J., Langlois X., Gonalons N., Martin P., Bianchetti A., Le Fur G., Soubrie P. Antidepressant profile in rodents of SR 58611A, a new selective agonist for atypical β-adrenoceptors. Eur. J. Pharmacol. 219:1992;193-201.
37. 3-adrenoceptor mRNA in rat brain. Br. J. Pharmacol. 116:1995;2547-2548.
38. Susulic V. S., Frederich R. C., Lawitts J., Tozzo E., Kahn B. B., Harper M., Himms-Hagen J., Flier J. S., Lowell B. B. Targeted disruption of the β3-adrenergic receptor gene. J. Biol. Chem. 270:1995;29483-29492.
39. 3-adrenoceptor agonists) and food intake in genetically obese rats. Int. J. Obes. 14:1990;50.
40. Tsujii S., Bray G. A. Effects of glucose, 2-deoxyglucose, phlorizin, and insulin on food intake of lean and fatty rats. Am. J. Physiol. 258:1990;E476-E481.
41. Tsujii S., Bray G. A. Food intake of lean and obese Zucker rats following ventricular infusions of adrenergic agonists. Brain Res. 587:1992;226-232.
42. Tsujii S., Bray G. A. GABA-related feeding control in genetically obese rats. Brain Res. 540:1991;48-54.
43. 2-adrenergic receptors. Life Sci. 53:1993;669-679.
44. Yamashita J., Onai T., York D. A., Bray G. A. Relationship between food intake and metabolic rate in rats treated with β-adrenoceptor agonists. Int. J. Obes. 18:1994;429-433.
45. Yen T. T. Antiobesity and antidiabetic β-agonists Lessons learned and questions to be answered . Obes. Res. 2:1994;472-480.