Total synthesis of analogs of topostin B, A DNA topoisomerase I inhibitor. Part 4: Synthesis of topostin B-2 analogs

Tetrahedron

Volumn 54, Issue 3-4, 1998, Pages 565-572

  Fujiwara, Hideyasu ^a   Egawa, Sadahiro ^a   Terao, Yoshihiro ^a   Aoyama, Toyohiko ^a   Shioiri, Takayuki ^a  

^a NAGOYA CITY UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

DNA TOPOISOMERASE INHIBITOR; TOPOSTIN B 2 DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL REACTION; DRUG SYNTHESIS; PRIORITY JOURNAL; TECHNIQUE;

EID: 0032518942     PISSN: 00404020     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4020(97)10316-7     Document Type: Article

References (8)

1. 1. The preceding paper.
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3. (b) Ikegami, Y.; Takeuchi, N.; Hanada, M.; Hasegawa, Y.; Ishii, K.; Andoh, T.; Sato, T.; Suzuki, K.; Yamaguchi, H.; Miyazaki, S.; Nagai, K.; Watanabe, S.; Saito, T. J. Antibiot. 1990, 43, 158.
4. 3. Griffith, W.P.; Ley, S.V.; Whitcombe, G.P.; White, A.D. J. Chem. Soc. Chem. Commun. 1987, 1625
5. 5 as shown below, and the crude products were used for the next step without further purification. (Formula presented)
6. 5. (a) Smith, L.I.; Sprung, J. A. J. Am. Chem. Soc. 1943, 65, 1276.
7. (b) McDougal, G.; Rico, G.; Imoh, Y.; Condon, D. J. Org. Chem. 1986, 51, 3388.
8. 6. Tius, M.A.; Fauq, A.H. J. Am. Chem. Soc. 1986, 108, 1035.