Effects of increasing doses of alpha-tocopherol in providing protection of low-density lipoprotein from oxidation

American Journal of Cardiology

Volumn 81, Issue 2, 1998, Pages 231-233

  Fuller, Cindy J ^b   Huet, Beverley A ^b   Jialal, Ishwarlal ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA TOCOPHEROL; LOW DENSITY LIPOPROTEIN; THIOBARBITURIC ACID REACTIVE SUBSTANCE;

ANTIOXIDANT ACTIVITY; ARTICLE; ATHEROGENESIS; ATHEROSCLEROSIS; DIET SUPPLEMENTATION; HEART PROTECTION; HUMAN; MACROPHAGE; MONOCYTE; PRIORITY JOURNAL;

ANTIOXIDANTS; ASCORBATE OXIDASE; BETA CAROTENE; CLINICAL TRIALS; CORONARY ARTERIOSCLEROSIS; DOSE-RESPONSE RELATIONSHIP, DRUG; FOLLOW-UP STUDIES; HUMANS; LIPOPROTEINS, LDL; MALE; OXIDATION-REDUCTION; VITAMIN E;

EID: 0032518937     PISSN: 00029149     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0002-9149(97)00873-4     Document Type: Article

References (15)

1. 1. Berliner JA, Navab M, Fogelman AM, Frank JS, Demer LL, Edwards PA, Watson AD, Lusis AJ. Atherosclerosis: basic mechanisms, oxidation, inflammation and genetics. Circulation 1995;91:2488-2496.
2. 2. Parthasarathy S, Rankin SM. Role of oxidized LDL in atherogenesis. Prog Lipid Res 1992;31:127-143.
3. 3. Fuller CJ, Jialal I. Antioxidants and LDL oxidation. In: Garewal H, ed. Antioxidants & Disease Prevention. Boca Raton: CRC Press, 1997;115-130.
4. 4. Janero DR. Therapeutic potential of vitamin E in the pathogenesis of spontaneous atherosclerosis. Free Radic Biol Med 1991;11:129-144.
5. 5. Traber MG, Sies H. Vitamin E in humans: demand and delivery. Ann Rev Nutr 1996;16:321-347.
6. 6. Princen HMG, van Poppel G, Vogelezang C, Buytenhek R, Kok FJ. Supplementation with vitamin E but not β-carotene in vivo protects low density low density lipoprotein from lipid peroxidation in vitro: effect of cigarette smoking. Arterioscler Thromb 1992;12:554-562.
7. 7. Dieber-Rotheneder M, Puhl H, Waeg G, Striegl G, Esterbauer H. Effect of oral supplementation with d-alpha-tocopherol on the vitamin E content of human low density lipoproteins and resistance to oxidation. J Lipid Res 1991;32:1325-1332.
8. 8. Jialal I, Grundy SM. Effect of dietary supplementation with alpha-tocopherol on the oxidative modification of low density lipoprotein. J Lipid Res 1992;33: 899-906.
9. 9. Reaven PD, Khouw A, Beltz WF, Parthasarathy S, Witztum JL. Effect of dietary antioxidant combinations in humans: protection of LDL by vitamin E but not by β-carotene. Arterioscler Thromb 1993;13:590-600.
10. 10. Harats D, Ben-Naim M, Dabach Y, Hollander G, Havivi E, Stein O, Stein Y. Effect of vitamin C and E supplementation on susceptibility of plasma lipoproteins to peroxidation induced by acute smoking. Artherosclerosis 1990;85:47-54.
11. 11. Jialal I, Fuller CJ, Huet BA. The effect of alpha-tocopherol supplementation on LDL oxidation: a dose response study. Arterioscler Thromb Vasc Biol 1995; 15:190-198.
12. 12. Simons LA, Von Konigsmark M, Balasubramaniam S. What dose of vitamin E is required to reduce susceptibility of LDL to oxidation? Aust NZ J Med 1996;26:496-503.
13. 13. Suzukawa M, Ishikawa T, Yoshida H, Nakamura H. Effect of in vivo supplementation with low dose vitamin E on susceptibility of low density lipoprotein and high density lipoprotein to oxidative modification. J Am Coll Nutr 1995;14:46-52.
14. 14. Princen HMG, van Duyvenvoorde W, Buytenhek R, van der Laarse A, van Poppel G, Leuven JAG, van Hinsbergh VWM. Supplementation with low doses of vitamin E protect LDL from lipid peroxidation in men and women. Arterioscler Thromb Vasc Biol 1995;15:325-333.
15. 15. Devaraj S, Li DJ, Jialal I. The effects of alpha-tocopherol supplementation on monocyte function: decreased lipid oxidation, interleukin-1 secretion and monocyte adhesion to endothelium. J Clin Invest 1996;98:756-763.