Total synthesis of analogs of topostin B, A DNA topoisomerase I inhibitor. Part 3: Improved synthesis of topostin B-1 analogs

Tetrahedron

Volumn 54, Issue 3-4, 1998, Pages 551-564

  Fujiwara, Hideyasu ^a   Aoyama, Toyohiko ^a   Shioiri, Takayuki ^a  

^a NAGOYA CITY UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

DNA TOPOISOMERASE INHIBITOR; TOPOSTIN B 1 DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL REACTION; DRUG SYNTHESIS; PRIORITY JOURNAL; TECHNIQUE;

EID: 0032518805     PISSN: 00404020     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4020(97)10315-5     Document Type: Article

References (11)

1. 1. Noguchi, H.; Aoyama, T.; Shioiri, T. Tetrahedron 1995, 51, 10531.
2. 2. Noguchi, H.; Aoyama, T.; Shioiri, T. Tetrahedron 1995, 57, 10545.
3. 3. (a) Suzuki, K.; Yamaguchi, H.; Miyazaki, S.; Nagai, K.; Watanabe, S.; Saito, T.; Ishii, K.; Hanada, M; Sekine, T.; Ikegami, Y.; Andoh, T. J. Antibiot. 1990, 43, 154.
4. (b) Ikegami, Y.; Takeuchi, N.; Hanada, M.; Hasegawa, Y.; Ishii, K.; Andoh, T.; Sato, T.; Suzuki, K.; Yamaguchi, H.; Miyazaki, S.; Nagai, K.; Watanabe, S.; Saito, T. J. Antibiot. 1990, 43, 158.
5. 4. Pattenden, G.; Teague, S. J. J. Chem. Soc. ParkinTrans. 1 1988, 1077
6. 5. Griffith, W.P.; Ley, S.V.; Whitcombe, G.P.; White, A. D. J. Chem. Soc. Chem. Commun. 1987, 1625
7. 6. (a) Smith, L.I.; Sprung, J. A. J. Am. Chem. Soc. 1943, 65, 1276.
8. (b) McDougal, G.; Rico, G.; Imoh, Y.; Condon, D. J. Org. Chem. 1986, 51, 3388.
9. 7. Hammond, G.B.; Cox, M.B.; Wiemer, D.F. J. Org. Chem. 1990, 55, 128.
10. 8. Tius, M.A.; Fauq, A.H. J. Am. Chem. Soc. 1986, 108, 1035.
11. 9. Some of the synthesized compounds proved to show inhibitor activity against mammalian DNA topoisomerase I by Prof. Andoh (private communication).