Solid-phase synthesis of dehydroalanine derivatives

Tetrahedron Letters

Volumn 39, Issue 3-4, 1998, Pages 289-292

  Yamada, Masaki ^a   Miyajima, Tadatoshi ^a   Horikawa, Hiroshi ^a  

^a MITSUBISHI TANABE PHARMA CORPORATION   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE DERIVATIVE; DEHYDROALANINE;

ARTICLE; DRUG SYNTHESIS; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; REACTION ANALYSIS;

EID: 0032518767     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(97)10544-5     Document Type: Article

References (19)

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12. 2 atmosphere to avoid oxidation of cysteine.
13. 6. Construction of dehydroalanine moiety via β-elimination of sulfone group has been reported. a) Kelly-Basetti, B. M.; Mackay, M. F.; Pereira, S. M.; Savage, G. P.; Simpson, G. W. Heterocycles 1994, 37, 529.
14. b) Gosselin, F.; Renzo, M. D.; Ellis, T. H.; Lubell, W. D. J. Org. Chem. 1996, 61, 7980.
15. 2Cl/g : Polystyrene 1% divinylbenzene copolymer) was purchased from Watanabe Chemical Industries, Ltd.
16. 8. A trace of β-elimination product from the resin via S-alkylation was detected by TLC for each case.
17. -1)
18. 4 and concentration under reduced pressure provided 4b (Table 1).
19. +.