Modulation of DNA-protein interactions in the P1 and P2 c-myc promoters by two intercalating drugs

European Journal of Biochemistry

Volumn 251, Issue 1-2, 1998, Pages 435-442

  Vaquero, Alejandro ^a   Portugal, José ^a  

^a DEPT OF ENVIRONMENTAL CHEMISTRY   (Spain)

Author keywords

Actinomycin D; c myc; Elasamicin A; Transcription

Indexed keywords

DACTINOMYCIN; ELSAMICIN A;

ARTICLE; BINDING SITE; CONSENSUS SEQUENCE; MODULATION; ONCOGENE C MYC; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DNA INTERACTION; TRANSCRIPTION REGULATION;

EID: 0032518463     PISSN: 00142956     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1432-1327.1998.2510435.x     Document Type: Article

References (30)

1. Hay, N., Bishop, M. & Levens, D. (1987) Regulatory elements that modulate expression of human c-myc, Genes & Dev. 1, 659-671.
2. Marcu, K. B., Bossone, S. A. & Patel, A. J. (1992) myc function and regulation, Annu. Rev. Biochem. 61, 809-860.
3. Arcinas, M. & Boxer, L. M. (1994) Differential protein binding to the c-myc promoter during differentiation of hematopoietic cell lines, Oncogene 9, 2699-2706.
4. Dufort, D. & Nepveu, A. (1994) The human cut homeodomain protein represses transcription from the c-myc promoter, Mol. Cell. Biol. 14, 4251-4257.
5. Ryan, K. M. & Birnie, G. D. (1996) Myc oncogenes: the enigmatic family, Biochem. J. 314, 713-721.
6. DesJardins, E. & Hay, N. (1993) Repeated CT elements hound by zinc finger proteins control the absolute and relative activities of the two principal human c-myc promoters, Mol. Cell. Biol. 13, 5710-5724.
7. Krumm, A., Hickey, L. B. & Groudine, M. (1995) Promoter-proximal pausing of RNA polymerase II defines a general rate-limiting step after transcription initiation, Genes & Dev. 9, 559-572.
8. Allen, S. L., Schacter, L. P., Lichtman, S. M., Bukowski, R., Fusco, D., Hensley, M., O'Dwyer, P., Mittelman, A., Rosenbloom, B. & Huybensz, S. (1996) Phase II study of elsamitrucin (BMY-28090) for the treatment of patients with refractory/relapsed non-Hodgkin's lymphoma, Invest. New Drugs 14, 213-217.
9. Hassan, H. T. & Rees, J. K. (1989) Low concentrations of cytosine arabinoside, 6-thioguanine, actinomycin-D and aclacinomyein A stimulates the differentiation of normal human marrow myeloid progenitor cells, Med. Oncol. Tumor. Pharmacother. 6, 213-217.
10. Fox, K. R. & Waring, M. J. (1984) DNA structural variations produced by actinomycin and distainycin as revealed by DNase 1 footprinting, Nucleic Acids Res. 12, 8271-8285.
11. Salas, X. & Portugal, J. (1991) Map of chartreusin and elsamicin binding sites on DNA, FEBS Lett. 292, 223-228.
12. Alhambra, C., Luque, F. J., Portugal, J. & Orozco, M. (1995) Molecular dynamics study of the binding of elsamicin A to DNA, Eur. J. Biochem. 230, 555-566.
13. Rodríguez-Campos, A., Azorín, F. & Portugal, J. (1996) Influence of elsamicin A on the activity of mammalian topoisomerase I, Biochemistry 35, 11 177- 11 182.
14. Fletcher, M. C. & Fox, K. R. (1996) Dissociation kinetics of actinomycin D from individual GpC sites in DNA, Eur. J. Biochem. 237, 164-170.
15. Phillips, D. R., White, R. J., Trist, H., Cullinane, C., Dean, D. & Crothers, D. M. (1990) New insight into drug-DNA interactions at individual drug binding sites probed by RNA polymerase during active transcription of the DNA, Anti-Cancer Drug Des. 5, 21-29.
16. Portugal, J. (1995) Abortive transcription of the T7 promoter induced by elsamicin A, Anti-Cancer Drug Des. 10, 427-438.
17. Bunch, R. T., Povirk, L. F., Orr, M. S., Randolph, J. K., Fornari, F. A. & Gewirtz, D. A. (1994) Influence of amsacrine (m-AMSA) on bulk and gene-specific DNA damage and c-myc expression in MCF-7 breast tumor cells, Biochem. Pharmacol. 47, 317-329.
18. Snyder, R. C., Ray, R., Blume, S. & Miller, D. M. (1991) Mithramycin blocks transcriptional initiation of the c-myc P1 and P2 promoters, Biochemistry 30, 4290-4297.
19. Fornari, F. A., Jarvis, W. D., Grant, S., Orr, M. S., Randolph, J. K., White, F. K. H. & Gewirtz, D. A. (1996) Growth arrest and non-apoptotic cell death associated with the suppression of c-myc expression in MCF-7 breast tumor cells following acute exposure to doxorubicin, Biochem. Pharmacol. 51, 931-940.
20. Briggs, M. R., Kadonaga, J. T., Bell, S. P. & Tjian, R. (1986) Purification and biochemical characterization of the promoter-specific transcription factor Sp1. Science 234, 47-52.
21. Keniry, M. A., Banville, D. L., Simmonds, P. M. & Shafer, R. (1993) Nuclear magnetic resonance comparison of the binding sites of mithramycin and chromomycin on the self-complementary oligonucleotide d(ACCCGGGT)2. Evidence that the saccharide chains have a role in sequence specificity, J. Mol. Biol. 231, 753-767.
22. Chaudhary, D. & Miller, D. M. (1995) The c-myc promoter binding protein (MBP-1) and TBP bind simultaneously in the minor groove of the c-myc P2 promoter, Biochemistry 34, 3438-3445.
23. Párraga, A. & Portugal, J. (1992) Detection of elsamicin-DNA binding specificity by restriction enzyme cleavage, FEBS Lett. 300, 25-29.
24. Kuwahara, J., Yonezawa, A., Futamura, M. & Sugiura, Y. (1993) Binding of transcription factor Sp1 to GC box DNA revealed by footprinting analysis: different contact of three zinc fingers and sequence recognition mode, Biochemistry 32, 5994-6001.
25. Chiang, S.-Y., Welch, J. J., Rauscher, F. J. & Beerman, T. A. (1996) Effect of DNA-binding drugs on early growth response factor-1 and TATA box-binding protein complex formation with the herpes simplex virus latency promoter, J. Biol. Chem. 271, 23 999-24 004.
26. Welch, J. J., Rauscher, F. J. & Beerman, T. A. (1994) Targeting DNA-binding drugs to sequence-specific transcription factor-DNA complexes. Differential effects of intercalating and minor groove binding drugs, J. Biol. Chem. 269, 31 051-31 058.
27. Bianchi, N., Passadore, M., Rutigliano, C., Feriotto, G., Mischiati, C. & Gambari, R. (1996) Targeting of the SpI binding sites of HIV-1 long terminal repeat with chromomycin-disruption of nuclear factor. DNA complexes and inhibition of in vitro transcription, Biochem. Pharmacol. 52, 1489-1498.
28. Bellorini, M., Moncollin, V. Dincalci, M., Mongelli, N. & Mantovani, R. (1995) Distamycin a and tallimustine inhibit TBP binding and basal in vitro transcription, Nucleic Acids Res. 23, 1657-1663.
29. Mote, J., Ghanouni, P. & Reines, D. (1994) A DNA minor groove-binding ligand both potentiates and arrests transcription by RNA polymerase II. Elongation factor SII enables readthrough at arrest sites, J. Mol. Biol. 236, 725-737.
30. Plet, A., Eick, D. & Blanchard, J. M. (1995) Elongation and premature termination of transcripts initiated from c-fos and c-myc promoters show dissimilar patterns, Oncogene 10, 319-328.