Characterization of rhesus cytomegalovirus genes associated with anti- viral susceptibility

Virology

Volumn 240, Issue 2, 1998, Pages 338-348

  Swanson, Ryan ^a   Bergquam, Eric ^a   Wong, Scott W ^a,b  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^b OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACICLOVIR; ANTIVIRUS AGENT; DNA POLYMERASE; GANCICLOVIR; PHOSPHOTRANSFERASE; VIRUS DNA;

AMINO ACID SEQUENCE; ANIMAL CELL; ANTIVIRAL ACTIVITY; ARTICLE; CONTROLLED STUDY; CYTOMEGALOVIRUS; DNA SEQUENCE; DRUG SCREENING; DRUG SENSITIVITY; NONHUMAN; NUCLEOTIDE SEQUENCE; OPEN READING FRAME; PRIORITY JOURNAL; RHESUS MONKEY; SEQUENCE HOMOLOGY; SOUTHERN BLOTTING;

ANIMALIA; CERCOPITHECINE HERPESVIRUS 8; CUCUMBER MOSAIC VIRUS; CYTOMEGALOVIRUS; DNA VIRUSES; MACACA; MACACA MULATTA;

EID: 0032518234     PISSN: 00426822     EISSN: None     Source Type: Journal    
DOI: 10.1006/viro.1997.8935     Document Type: Article

References (56)

1. Alcendor D. J., Barry P. A., Pratt-Lowe E., Luciw P. A. Analysis of the rhesus cytomegalovirus immediate-early gene promoter. Virology. 194:1993;815-821.
2. Aron G. M., Purifoy D. J. M., Schaffer P. A. DNA synthesis and DNA polymerase activity of herpes simplex virus type 1 temperature-sensitive mutants. J. Virol. 16:1975;498-507.
3. Asher D. M., Gibbs C. J. Jr., Lang D. J., Gajdusek D. C. Persistent shedding of cytomegalovirus in the urine of healthy rhesus monkeys (37897). Proc. Soc. Exp. Biol. Med. 145:1974;794-801.
4. Baldanti F., Silini E., Sarasini A., Talarico C. L., Stanat S. C., Biron K. K., Furione M., Bono F., Palu G., Gerna G. A three-nucleotide deletion in the UL97 open reading frame is responsible for the ganciclovir resistance of a human cytomegalovirus clinical isolate. J. Virol. 69:1995;796-800.
5. Bankier A. T., Beck S., Bohni R., Brown C. M., Cerny R., Chee M. S., Hutchison C. A. III, Kouzarides T., Martignetti J. A., Preddie E., Satchwell S. C., Tomlinson P., Weston K. M., Barrell B. G. The DNA sequence of the human cytomegalovirus genome. J. DNA Sequencing Mapping. 2:1991;1-12.
6. Baroncelli S., Barry P. A., Capitanio J. P., Lerche N. W., Otsyula M., Mendoza S. P. Cytomegalovirus and simian immunodeficiency virus coinfection: Longitudinal study of antibody responses and disease progression. J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. 15:1997;5-15.
7. Barry P. A., Alcendor D. J., Power M. D., Kerr H., Luciw P. A. Nucleotide sequence and molecular analysis of the rhesus cytomegalovirus immediate-early gene and the UL121-117 open reading frames. Virology. 215:1996;61-72.
8. Baskin G. B. Disseminated cytomegalovirus infection in immunodeficient rhesus monkeys. Am. J. Pathol. 129:1987;345-352.
9. Biron K. K., Stanat S. C., Sorrell J. B., Fyfe J. A., Keller P. M., Lambe C. U., Nelson D. J. Metabolic activation of the mucleoside analog 9-{[2-hydroxy-1-(hydroxymethyl)ethoxy]methly}guanine in human diploid fibroblasts infected with human cytomegalovirus. Proc. Natl. Acad. Sci. USA. 82:1985;2473-2477.
10. Biron K. K., Fyfe J. A., Stanat S. C., Leslie L. K., Sorrell J. B., Lambe C. U., Coen D. M. A human cytomegalovirus mutant resistant to the nucleoside analog 9-{[2-hydroxy-1-(hydroxymethyl)ethoxy]methyl}guanine (BW B759U) induces reduced levels of BW B759U triphosphate. Proc. Natl. Acad. Sci. USA. 83:1986;8769-8773.
11. Chee M. S., Bankier A. T., Beck S., Bohni R., Brown C. M., Cerny R., Horsnell T., Hutchison C. A. III, Kouzarides T., Martignetti J. A., Preddie E., Satchwell S. C., Tomlinson P., Weston K. M., Barrell B. G. Analysis of the protein-coding content of the sequence of human cytomegalovirus strain AD169. Curr. Top. Microbiol. Immunol. 154:1990;125-169.
12. Chirgwin J. M., Przybyla A. E., MacDonald R. J., Rutter W. J. Isolation of biologically active RNA from sources enriched in ribonuclease. Biochemistry. 18:1979;5294-5299.
13. Chou S., Guentzel S., Michels K. R., Miner R. C., Drew W. L. Frequency of UL97 phosphotransferase mutations related to ganciclovir resistance in clinical cytomegalovirus isolates. J. Infect. Dis. 172:1995;239-242.
14. Copeland W. C., Wang T. S.-F. Mutational studies of human DNA polymerase I. The most conserved region in I-like DNA polymerases is involved in metal-specific catalysis. J. Biol. Chem. 268:1993;11028-11040.
15. Copeland W. C., Lam N. K., Wang T. S.-F. Fidelity studies of the human DNA polymerase I. The most conserved region among I-like DNA polymerases is responsible for metal-induced infidelity in DNA synthesis. J. Biol. Chem. 268:1993;11041-11049.
16. Dong Q., Copeland W. C., Wang T. S.-F. Mutational studies of human DNA polymerase I. Identification of residues critical for deoxynucleotide binding and misinsertion fidelity of DNA synthesis. J. Biol. Chem. 268:1993a;24163-24174.
17. Dong Q., Copeland W. C., Wang T. S.-F. Mutational studies of human DNA polymerase I. Serine 867 in the second most conserved region among I-like DNA polymerases is involved in primer binding and mispair primer extension. J. Biol. Chem. 268:1993b;24175-24182.
18. Dong Q., Wang T. S.-F. Mutational studies of human DNA polymerase I. Lysine 950 in the third most conserved region of I-like DNA polymerases is involved in binding the deoxynucleoside triphosphate. J. Biol. Chem. 270:1995;21563-21570.
19. Drew W. L. Cytomegalovirus infection in patients with AIDS. Clin. Infect. Dis. 14:1992;608-615.
20. Drew W. L., Miner R. C., Busch D. F., Follansbee S. E., Gullett J., Mehalko S. G., Gordon S. M., Owen W. F. Jr., Matthews T. R., Buhles W. C.et al. Prevalence of resistance in patients receiving ganciclovir for serious cytomegalovirus infection. J. Infect. Dis. 163:1991;716-719.
21. Elliott R., Clark C., Jaquish D., Spector D. H. Transcription analysis and sequence of the putative murine cytomegalovirus DNA polymerase gene. Virology. 185:1991;169-186.
22. Erice A., Chou S., Biron K. K., Stanat S. C., Balfour H. H. Jr., Jordan M. C. Progressive disease due to ganciclovir-resistant cytomegalovirus in immunocompromised patients. N. Engl. J. Med. 320:1989;289-293.
23. Fleckenstein B., Müller I., Collins J. Cloning of the complete human cytomegalovirus genome in cosmids. Gene. 18:1982;39-46.
24. Gibbs J. S., Chiou H. C., Bastow K. F., Cheng Y.-C., Coen D. M. Identification of aas in herpes simplex virus DNA polymerase involved in substrate and drug recognition. Proc. Natl. Acad. Sci. USA. 85:1988;6672-6676.
25. Griffith B. P., Aquino-DeJesus M. J. C. Guinea pig model of congenital cytomegalovirus infection. Trans. Proc. 23:1991;29-31.
26. Hanks S. K., Quinn A. M., Hunter T. The protein kinase family: Conserved features and deduced phylogeny of the catalytic domains. Science. 241:1988;42-52.
27. He Z., He Y.-S., Kim Y., Chu L., Ohmstede C., Biron K. K., Coen D. M. The human cytomegalovirus UL97 protein is a protein kinase that autophosphorylates on serines and threonines. J. Virol. 71:1997;405-411.
28. Heilbronn R., Jahn G., Bürkle A., Freese U.-K., Fleckenstein B., Zur Hausen H. Genomic localization, sequence analysis, and transcription of the putative human cytomegalovirus DNA polymerase gene. J. Virol. 61:1987;119-124.
29. Hendrickx A. G., Binkerd P. E. Nonhuman primates and teratological research. J. Med. Primatol. 19:1990;81-108.
30. Higgins D. G., Sharp P. M. Fast and sensitive multiple sequence alignments on a microcomputer. Comput. Appl. Biosci. 5:1989;151-153.
31. Hirsch, M. S. 1994, Herpes group virus infections in the compromised host, In, Clinical Approach to Infection in the Compromised Host, 379, 396, Plenum, New York.
32. Hwang C. B. C., Ruffner K. L., Coen D. M. A point mutation within a distinct conserved region of the herpes simplex virus DNA polymerase gene confers drug resistance. J. Virol. 66:1992;1774-1776.
33. Ibanez C. E., Schrier R., Ghazal P., Wiley C., Nelson J. A. Human cytomegalovirus productively infects primary differentiated macrophages. J. Virol. 65:1991;6581-6588.
34. Kerry J. A., Priddy M. A., Jervey T. Y., Kohler C. P., Staley T. I., Vanson C. D., Jones T. R., Iskenderian A. C., Anders D. G., Stenberg R. M. Multiple regulatory events influence human cytomegalovirus DNA polymerase (UL54) expression during viral infection. J. Virol. 70:1996;373-382.
35. Kravitz R. H., Loomis J. E., Sciabica K. S., Luciw P. A., Barry P. A. Cloning and characterization of rhesus cytomegalovirus glycoprotein B. J. Gen. Virol. 78:1997;2009-2013.
36. Kouzarides T., Bankier A. T., Satchwell S. C., Weston K., Tomlinson P., Barrell B. G. Sequence and transcription analysis of the human cytomegalovirus DNA polymerase gene. J. Virol. 61:1987;125-133.
37. Littler E., Stuart A. D., Chee M. S. Human cytomegalovirusUL97. Nature. 358:1992;160-162.
38. Lurain N. S., Thompson K. D., Holmes E. W., Read G. S. Point mutations in the DNA polymerase gene of human cytomegalovirus that result in resistance to anti-viral agents. J. Virol. 66:1992;7146-7152.
39. Lurain N. S., Spafford L. E., Thompson K. D. Mutation in the UL97 open reading frame of human cytomegalovirus strains resistant to ganciclovir. J. Virol. 68:1994;4427-4431.
40. Matthews T., Boehme R. Anti-viral activity and mechanism of action of ganciclovir. Rev. Infect. Dis. 10:1988;S490-S494.
41. McGeoch D. J., Cook S., Dolan A., Jamieson F. E., Telford E. A. R. Molecular phylogeny and evolutionary timescale for the family of mammalian herpesviruses. J. Mol. Biol. 247:1995;443-458.
42. Michel D., Pavić I., Zimmermann A., Haupt E., Wunderlich K., Heuschmid M., Mertens T. The UL97 gene product of human cytomegalovirus is an early-late protein with a nuclear localization but is not a nucleoside kinase. J. Virol. 70:1996;6340-6346.
43. Mocarski E. S., Bonyhadi M., Salimi S., McCune J. M., Kaneshima H. Human cytomegalovirus in a SCID-hu mouse: Thymic epithelial cells are prominent targets of viral replication. Proc. Natl. Acad. Sci. USA. 90:1993;104-108.
44. Rawlinson W. D., Farrell H. E., Barrell B. G. Analysis of the complete DNA sequence of murine cytomegalovirus. J. Virol. 70:1996;8833-8849.
45. Rawlinson W. D., Zeng F., Farrell H. E., Cunningham A. L., Scalzo A. A., Booth T. W. M., Scott G. M. The murine cytomegalovirus (MCMV) homolog of the HCMV phosphotransferase (UL97(pk)) gene. Virology. 233:1997;358-363.
46. Rubin R. H. Impact of cytomegalovirus infection on organ transplant recipients. Rev. Infect. Dis. 12:1990;S754-S766.
47. Schleiss M. R. Sequence and transcriptional analysis of the guinea pig cytomegalovirus DNA polymerase gene. J. Gen Virol. 76:1995.
48. Shanley J. D., Morningstar J., Jordan M. C. Inhibition of murine cytomegalovirus lung infection and interstitial pneumonitis by acyclovir and 9-(1,3-dihydroxy-2-propoxymethyl)guanine. Antimicrob. Agents Chemother. 28:1985;172-175.
49. Stenberg R. M., Fortney J., Barlow S. W., Magrane B. P., Nelson J. A., Ghazal P. Promoter-specifictrans. J. Virol. 64:1990;1556-1565.
50. Sullivan V., Talarico C. L., Stanat S. C., Davis M., Coen D. M., Biron K. K. A protein kinase homologue controls phosphorylation of ganciclovir in human cytomegalovirus-infected cells. Nature. 358:1992;162-164.
51. Sullivan V., Biron K. K., Talarico C., Stanat S. C., Davis M., Pozzi L. M., Coen D. M. A point mutation in the human cytomegalovirus DNA polymerase gene confers resistance to ganciclovir and phosphonylmethoxyalkyl derivatives. Antimicrob. Agents Chemother. 37:1993;19-25.
52. Swack N. S., Hsiung G. D. Natural and experimental simian cytomegalovirus infections at a primate center. J. Med. Primatol. 11:1982;169-177.
53. Vogel P., Weigler B. J., Kerr H., Hendrickx A. G., Barry P. A. Seroepidemiologic studies of cytomegalovirus infection in a breeding population of rhesus macaques. Lab. Anim. Med. 44:1994;25-30.
54. Wing B. A., Huang E.-S. Analysis and mapping of a family of 3′-coterminal transcripts containing coding sequences for human cytomegalovirus open reading frames UL93 through UL99. J. Virol. 69:1995;1521-1531.
55. Wong S. W., Wahl A. F., Yuan P.-M., Arai N., Pearson B. E., Arai K., Korn D., Hunkapiller M. W., Wang T. S.-F. Human DNA polymerase I gene expression is cell proliferation dependent and its primary structure is similar to both prokaryotic and eukaryotic replicative DNA polymerases. EMBO J. 7:1988;37-47.
56. Zhang J., Chung D. W., Tan C.-K., Downey K. M., Davie E. W., So A. G. Primary structure of the catalytic subunit of calf thymus DNA polymerase L: Sequence similarities with other DNA polymerases. Biochemistry. 30:1991;11742-11750.