Methoxy-polyethoxy side-chain silastomers as materials controlling drug delivery by diffusion flux

Journal of Controlled Release

Volumn 54, Issue 3, 1998, Pages 273-282

  Loth, Helmut ^a   Foltin, Ulrich ^a  

^a Im Stadtwald   (Germany)

Author keywords

Drug delivery; Drug permeation; Drug solubility; Lyotropic liquid crystallinity; Methoxy polyethoxy side chain silastomers; Variable density of the matrix; Variable polarity

Indexed keywords

POLYMER; POLYSILOXANE; SALICYLIC ACID;

ARTICLE; DIFFUSION; DIFFUSION COEFFICIENT; DRUG DELIVERY SYSTEM; DRUG RELEASE; DRUG SOLUBILITY; DRUG SYNTHESIS; PRIORITY JOURNAL; THERMAL ANALYSIS;

DIFFUSION; DRUG DELIVERY SYSTEMS; MOLECULAR WEIGHT; PERMEABILITY; PHARMACEUTIC AIDS; POLYETHYLENE GLYCOLS; SILICONE ELASTOMERS; SOLUBILITY; THERMODYNAMICS;

EID: 0032516619     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-3659(97)00218-6     Document Type: Article

References (21)

1. R.J. Kostelnik (Ed.), Polymeric Delivery Systems, Gordon and Breach Science Publishers, New York, London, Paris, 1976.
2. Y.W. Chien, in: D.R. Paul, F.W. Harris (Eds.), Controlled-release Polymeric Formulations, American Chemical Society, Washington, D.C., 1976, p. 53.
3. D.S.T. Hsieh, C.C. Chiang, D.S. Desai, Controlled release of macromolecules from silicone elastomer, Pharm. Technol. June (1985) 39-49.
4. McGinity J.W., Hunke L.A., Combs A.B. Effect of water-soluble carriers on morphine sulfate release from a silicone polymer. J. Pharm. Sci. 68:1979;662-664.
5. Carelli V., Di Colo G. Effect of different water-soluble additives on water sorption into silicone rubber. J. Pharm. Sci. 72:1983;316-317.
6. Lippold B.C., Kurka P. Füllstoffgesteuerte Freisetzung aus Suspensionsmatrix-Laminaten auf Basis von Silicon mit konstanter Abgaberate. Act. Pharm. Technol. 35:1989;82-84.
7. Rehula M. Effect of polyethylene glycol on the pharmaceutical availability of papaverine hydrochloride from silicone matrices. Pharmazie. 48:1993;126-128.
8. Toddywala R., Chien Y.W. Evaluation of silicone-based pressure-sensitive adhesives for transdermal drug delivery. I: Effect of penetrant hydrophilicity. J. Control. Release. 14:1990;29-41.
9. A. Euschen, Diffusion in Flüssigkristallinen Silastomeren, Doctoral Thesis, Saarbrücken, Germany, 1988.
10. Loth H., Euschen A. Diffusion flux control by liquid-crystalline side-chain polysiloxane elastomer foils. Makromol. Chem. Rapid Commun. 9:1988;35-38.
11. Loth H., Euschen A. Liquid-crystalline side-chain silastomers, largely-modifiable diffusion media for the control of drug delivery. Drug Devel. Ind. Pharm. 16:1990;2077-2095.
12. Bae Y.H., Okano T., Hsu R., Kim S.W. Thermosensitive polymers as on-off switches for drug release. Makromol. Chem. Rapid Commun. 8:1987;481-485.
13. Finkelmann H., Kock H.J., Rehage G. Liquid crystalline elastomers - a new type of liquid crystalline material. Makromol. Chem. Rapid Commun. 2:1981;317-322.
14. J. Chatt, L.M. Vallarino, L.M. Venanzi, Olefin coordination compounds, part IV, diene complexes of platinum(II), the structure of Hofmann and von Narbutt's [dicyclopentadiene(RO) Pt Cl], J. Chem. Soc. (1957) 2496-2505.
15. Lühmann B., Finkelmann H., Rehage G. Phase behaviour and structure of polymer surfactants in aqueous solution. The occurrence of lyotropic nematic phases. Makromol. Chem. 186:1985;1059-1073.
16. Feldstein M.M., Tohmakhchi V.N., Malkhazov L.B., Vasiliev A.E., Platé N.A. Hydrophilic polymeric matrices for enhanced transdermal drug delivery. Int. J. Pharm. 131:1996;229-242.
17. Dusek K., Prins W. Structure and elasticity of noncrystalline polymer networks. Adv. Polymer Sci. 6:1969;1-102.
18. C. Noel, Macroscopic structural characterization of sidechain liquid-crystal polymers, in: C.B. McArdle (Ed.), Sidechain Liquid Crystals, Glasgow 1989, pp. 159-195.
19. Chen Y., Matheson L.E. Quantitative structure-transportability relationship for the release of a series of substituted pyridines from a planar polydimethylsiloxane matrix. Int. J. Pharm. 94:1993;153-160.
20. Gander B., Gurny R., Doelker E., Peppas N.A. Effect of polymeric network structure on drug release from cross-linked poly(vinyl alcohol) micromatrices. Pharm. Res. 6:1989;578-584.
21. Lippold B.H., Lichey J.F. Arzneistofftransport durch lipophile Polymermembranen. Act. Pharm. Technol. 30:1984;140-154.