Asmarines A-C; three novel cytotoxic metabolites from the marine sponge Raspailia sp.

Tetrahedron Letters

Volumn 39, Issue 20, 1998, Pages 3323-3326

  Yosief, Tesfamariam ^a   Rudi, Amira ^a   Stein, Zafra ^a   Goldberg, Israel ^a   Gravalos, Garcia M D ^b   Schleyer, Michael ^c   Kashman, Yoel ^a  

^a TEL AVIV UNIVERSITY   (Israel)

^b Instituto Biomar SA   (Spain)

^c OCEANOGRAPHIC RESEARCH INSTITUTE   (South Africa)

Author keywords

[No Author keywords available]

Indexed keywords

ASMARINE A; ASMARINE B; ASMARINE C; CHELODANE; DITERPENOID; UNCLASSIFIED DRUG; ZAATIRIN;

ANIMAL CELL; ARTICLE; CANCER CELL; COLON CARCINOMA; CYTOTOXICITY; DRUG ISOLATION; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; LEUKEMIA; LUNG CARCINOMA; MELANOMA; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; SPONGE (PORIFERA); X RAY DIFFRACTION;

EID: 0032516324     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(98)00481-X     Document Type: Article

References (14)

1. 1. A globular, soft, prickly looking, mustard coloured sponge; which seems to be an unidentified sp.
2. 2. Rudi, A.; Kashman, Y. J. Nat. Prod., 1992, 55, 1408-1414.
3. -1; HREIMS m/z 423.2999, clacd. 423.2998.
4. H 4.22 s and 4.08 s, respectively.
5. -1, crystal size 0.03x0.20x0.20 mm.
6. 6. Sheldrick, G.M.; SHELXS-86 in "Crystallographic Computing 3" Sheldrick, G.M.; Kruger, C.; Goddard, R. Eds.; Oxford University Press 1985 pp. 175-189; Acta Cryst, 1990, A46, 467-473.
7. 6. Sheldrick, G.M.; SHELXS-86 in "Crystallographic Computing 3" Sheldrick, G.M.; Kruger, C.; Goddard, R. Eds.; Oxford University Press 1985 pp. 175-189; Acta Cryst, 1990, A46, 467-473.
8. 7. Sheldrick G.M.; SHELXL-97. Program for the Refinement of Crystal Structures from Diffraction Data, University of Goettingen, Germany, 1997.
9. C 21.2 t, 24.1 t, 31.6 t, 153.6 s, 39.3 s, 38.1 t, 27.2 t, 38.1 d, 40.5 d, 46.6 d, 31.1 t, 31.6 t, 64.9 s, 36.4 t, 42.3 t, 23.1 q, 15.8 q, 105.7 t, 32.9 q, 19.9 q (C-1÷20), 151.6 d, 149.6 s, 109.3 s, 158.4 s, 143.3 d (the purine carbons).
10. 9. Carney, J.R.; Scheuer P.J.; Tetrahedron Lett., 1993, 34, 3727-3730.
11. C 58.2 s, 144.3 d, 141.1 s, 109.5 s, 147.0 s (x2) and 26.8 q, - the other resonances as in 2.
12. 11. Bergeron, R.J.; Cavanaugh, P.F., Jr.; Kline, S.J.; Hughes, R.G. Jr.; Elliot, G.T. and Porter, C.W. (1984). Antineoplastic and antiherpetic activity of spermidine catecholamtde irons chelators. Biochemical and Biophisical Research Communications, 121(3): 848-854. : 7(4), p. 303-311. 1989.
13. 11. Bergeron, R.J.; Cavanaugh, P.F., Jr.; Kline, S.J.; Hughes, R.G. Jr.; Elliot, G.T. and Porter, C.W. (1984). Antineoplastic and antiherpetic activity of spermidine catecholamtde irons chelators. Biochemical and Biophisical Research Communications, 121(3): 848-854. : 7(4), p. 303-311. 1989.
14. 12. Capon, R.J.; Faulkner, D. J., J. Am. Chem. Soc., 1984, 106, 1819-1822.