Immunohistochemical localization of nicotinic β2 and α4 receptor subunits in normal human brain and individuals with Lewy body and Alzheimer's disease: Preliminary observations

Neuroscience Letters

Volumn 256, Issue 3, 1998, Pages 151-154

  Sparks, D Larry ^a   Beach, Thomas G ^a   Lukas, Ronald J ^b  

^a SUN HEALTH RESEARCH INSTITUTE   (United States)

^b Laboratory of Neurochemistry   (United States)

Author keywords

Aging; Alzheimer's; Neurofibrillary tangles; Neuropil threads; Senile plaques

Indexed keywords

NICOTINIC RECEPTOR; RECEPTOR SUBUNIT;

ALZHEIMER DISEASE; ARTICLE; BRAIN REGION; CONTROLLED STUDY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LEWY BODY; NEUROPIL; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN LOCALIZATION; SENILE PLAQUE; TEMPORAL CORTEX; TISSUE DISTRIBUTION;

ALZHEIMER DISEASE; ANTIBODIES, MONOCLONAL; HUMANS; IMMUNOHISTOCHEMISTRY; LEWY BODIES; NEUROFIBRILLARY TANGLES; PARKINSON DISEASE; RECEPTORS, NICOTINIC; SENILE PLAQUES; SUBSTANTIA NIGRA; TEMPORAL LOBE;

EID: 0032515031     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3940(98)00794-0     Document Type: Article

References (19)

1. Akima M., Nonaka H., Kagesawa M., Tanaka K. A study on the microvasculature of the cerebral cortex. Fundamental architecture and its senile change in the frontal cortex. Lab. Invest. 55:1986;482-489.
2. Beach T.G., McGeer E.G. Cholinergic fiber loss in the absence of synaptophysin depletion in Alzheimer's disease visual cortex. Neurosci. Lett. 142:1992;253-256.
3. Beach T.G., Honer W.G., Hughes L.H. Cholinergic fibre loss associated with diffuse plaques in the non-demented elderly: the preclinical stage of Alzheimer's disease? Acta Neuropathol. 93:1997;146-153.
4. Clarke P.B.S. Nicotinic receptors in mammalian brain: localization and relation to cholinergic function. Prog. Brain Res. 98:1993;77-83.
5. Deutch A.Y., Holliday J., Roth R.H., Chun L.L.Y., Hawrot E. Immunohistochemical localization of a neuronal nicotinic acetycholine receptor in mammalian brain. Proc. Natl. Acad. Sci. USA. 84:1987;8697-8701.
6. Geula C., Mesulam M.M. Cortical cholinergic fibers in aging and Alzheimer's disease: A morphometric study. Neuroscience. 33:1989;469-481.
7. Geula C., Mesulam M.-M., Saroff D.M., Wu C.-K. Relationship between plaques, tangles, and loss of cortical cholinergic fibers in Alzheimer disease. J. Neuropathol. Exp. Neurol. 57:1998;63-75.
8. Hill J.A., Zoli M., Bourgeois J.-P., Changeuz J.-P. Immunocytochemical localization of a neuronal nicotinic receptor: The beta2-subunit. J. Neurosci. 13:1993;1551-1558.
9. Lukas, R.J., Neuronal nicotinic acetylcholine receptors. In F.J. Barrantes (Ed.), The Nicotinic Acetylcholine Receptor: Current Views and Future Trends, Landes Bioscience, Georgetown, TX, 1998, p. 145-173.
10. Marks M.J., Pauly J.R., Gross S.D., Deneris E.S., Hermans-Borgmeyer I., Heinemann S.F., Collins A.C. Nicotine binding and nicotinic receptor subunit RNA after chronic nicotine treatment. J. Neurosci. 12:1992;2765-2784.
11. Perry E.K., Morris C.M., Court J.A., Cheng A., Fairbairn A.F., McKeith I.G., Irving D., Brown A., Perry R.H. Alterations in nicotinic binding sites in Parkinson's disease, Lewy body dementia and Alzheimer's disease: possible index of early neuropathology. Neurosci. 64:1995;385-395.
12. Ravens, J.R., Vascular changes in the human senile brain. In J. Cervos-Navarro, E. Betz, G. Eberhardt, R. Ferst and R. Wullenweber, Pathology of Cerebrospinal Microcirculation, Raven Press, New York, NY, 1978, pp. 487-501.
13. Rogers S.W., Mandelzys A., Deneris E., Cooper E., Heinemann S. The expression of nicotinic acetylcholine receptors by PC12 cells treated with NGF. J. Neurosci. 12:1992;4611-4623.
14. Schroder H., Zilles K., Maelicke A., Hajos F. Immunohisto- and cytochemical localization of cortical nicotinic cholinoceptors in rat and man. Brain Res. 502:1989;287-295.
15. Schroder H., Giacobini E., Struble R.G., Zilles K., Maelicke A. Nicotinic cholinoceptive neurons of the frontal cortex are reduced in Alzheimer's disease. Neurobiol. Aging. 12:1991;259-262.
16. Sparks D.L., Hunsaker J.C. Down's syndrome: occurrence of ALZ-50 reactive neurons and the formation of senile plaques. J. Neurol. Sci. 109:1992;77-82.
17. Sparks D.L., Liu H., Scheff S.W., Coyne C.M., Hunsaker III J.C. Temporal sequence of plaque formation in the cerebral cortex of non-demented individuals. J. Neuropath. Exp. Neurol. 52:1993;135-142.
18. van der Zee E.A., Streefland C., Strosberg A.D., Schroder H., Luiten P.G.M. Visualization of cholinoceptive neurons in the rat neocortex: colocalization of muscarinic and nicotinic acetylcholine receptors. Mol. Brain Res. 14:1992;326-336.
19. Wevers A., Jeske A., Lobron C., Birtsch C., Heinemann S., Maelicke A., Schroder R., Schroder H. Cellular distribution of nicotinic acetycholine receptor subunit mRNAs in the human cerebral cortex as revealed by non-isotopic in situ hybridization. Mol Brain Res. 25:1994;122-128.