Stabilization of radical intermediates by an active-site tyrosine residue in methylmalonyl-CoA mutase

Biochemistry

Volumn 37, Issue 41, 1998, Pages 14386-14393

  Thomä, Nicolas H ^a   Meier, Thomas W ^a,c   Evans, Philip R ^b   Leadlay, Peter F ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b MRC LABORATORY OF MOLECULAR BIOLOGY   (United Kingdom)

^c Cilag AG   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

COBAMAMIDE; METHYLMALONYL COENZYME A MUTASE; TYROSINE;

ARTICLE; BINDING AFFINITY; CATALYSIS; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME LOCALIZATION; ENZYME STABILITY; ENZYME SUBSTRATE; GENE REARRANGEMENT; HYDROGEN BOND; NONHUMAN; PRIORITY JOURNAL; X RAY CRYSTALLOGRAPHY;

AMINO ACID SUBSTITUTION; BINDING SITES; COBAMIDES; CRYSTALLIZATION; CRYSTALLOGRAPHY, X-RAY; DEUTERIUM; ENZYME STABILITY; FREE RADICALS; KINETICS; METHYLMALONYL-COA MUTASE; MUTAGENESIS, SITE-DIRECTED; PHENYLALANINE; PROPIONIBACTERIUM; TRITIUM; TYROSINE;

FELIS CATUS; PROPIONIBACTERIUM; PROPIONIBACTERIUM FREUDENREICHII SUBSP. SHERMANII; TRITIUM;

EID: 0032514774     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi981375o     Document Type: Article

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