Studies on quinazolines and 1,2,4-benzothiadiazine 1,1-dioxides. 8. Synthesis and pharmacological evaluation of tricyclic fused quinazolines and 1,2,4-benzothiadiazine 1,1-dioxides as potential α1-adrenoceptor antagonists

Journal of Medicinal Chemistry

Volumn 41, Issue 17, 1998, Pages 3128-3141

  Chern, Ji Wang ^b,c   Tao, Pao Luh ^a   Wang, Kuang Chao ^a   Gutcait, Alexander ^a,d   Liu, Shiou Wen ^b   Yen, Mao Hsiung ^a   Chien, Shu Lan ^b   Rong, Jiann Kuo ^a  

^a NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^b NATIONAL DEFENSE MEDICAL CENTER   (Taiwan)

^c NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^d RIGA TECHNICAL UNIVERSITY   (Latvia)

Author keywords

[No Author keywords available]

Indexed keywords

2 [[4 (2 METHOXYPHENYL)PIPERAZIN 1 YL]METHYL] 2,3 DIHYDROIMIDAZOL[1,2 C]QUINAZOLIN 5(6H) ONE; 2,3 DIHYDRO 3 [[4 (2 METHOXYPHENYL) 1 PIPERAZINYL]METHYL] 5 (METHYLTHIO)IMIDAZO[1,2 C]QUINAZOLINE; 3 [[4 (2 METHOXYPHENYL)PIPERAZIN 1 YL]METHYL] 2,3 DIHYDROIMIDAZOL[1,2 C]QUINAZOLIN 5(6H) ONE; ALPHA 1 ADRENERGIC RECEPTOR BLOCKING AGENT; UNCLASSIFIED DRUG;

ALPHA ADRENERGIC RECEPTOR BLOCKING; ANTIHYPERTENSIVE THERAPY; ARTICLE; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; HYPERTENSION; RECEPTOR AFFINITY;

ADRENERGIC ALPHA-AGONISTS; ANIMALS; ANTIHYPERTENSIVE AGENTS; BENZOTHIADIAZINES; BLOOD PRESSURE; CELL MEMBRANE; DRUG DESIGN; MALE; MOLECULAR STRUCTURE; PRAZOSIN; QUINAZOLINES; RATS; RATS, INBRED SHR; RECEPTORS, ADRENERGIC, ALPHA-1; RECEPTORS, ADRENERGIC, ALPHA-2; RECEPTORS, SEROTONIN; RECEPTORS, SEROTONIN, 5-HT1; STRUCTURE-ACTIVITY RELATIONSHIP; SUBMANDIBULAR GLAND;

EID: 0032514405     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm970159v     Document Type: Article

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