Fetal gender impact on multiple-marker screening results

American Journal of Medical Genetics

Volumn 76, Issue 5, 1998, Pages 369-371

  Bazzett, Lisa B ^a   Yaron, Yuval ^a,c   O'Brien, Joseph E ^b   Critchfield, Gregory ^b   Kramer, Ralph L ^a   Ayoub, Mazin ^a   Johnson, Mark P ^a   Evans, Mark I ^a  

^a WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b QUEST DIAGNOSTICS NICHOLS INSTITUTE   (United States)

^c TEL AVIV SOURASKY MEDICAL CENTER   (Israel)

Author keywords

Biochemical screening; Fetal gender; hCG; MSAFP; Prenatal diagnosis; uE3

Indexed keywords

ALPHA FETOPROTEIN; CHORIONIC GONADOTROPIN; ESTRIOL;

ADULT; ARTICLE; DOWN SYNDROME; FEMALE; FETUS; FETUS ECHOGRAPHY; HUMAN; MAJOR CLINICAL STUDY; MALE; MATERNAL AGE; MATERNAL SERUM; PRENATAL SCREENING; PRIORITY JOURNAL; RETROSPECTIVE STUDY; RISK ASSESSMENT; SECOND TRIMESTER PREGNANCY; SEX DIFFERENCE;

ALPHA-FETOPROTEINS; BIOLOGICAL MARKERS; CHORIONIC GONADOTROPIN; COHORT STUDIES; DOWN SYNDROME; ESTRIOL; FEMALE; FETAL DISEASES; GENETIC SCREENING; HUMANS; MALE; RETROSPECTIVE STUDIES; SENSITIVITY AND SPECIFICITY; SEX CHARACTERISTICS;

EID: 0032513572     PISSN: 01487299     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1096-8628(19980413)76:5<369::AID-AJMG1>3.0.CO;2-I     Document Type: Article

References (13)

1. Calvas P, Bourrouillou G, Smilovici W, Colombies P (1990): Maternal serum alpha-fetoprotein and fetal sex. Prenat Diagn 10:134-136.
2. Evans MI, O'Brien JE, Dvorin E, Johnson MP (1994): Biochemical screening. Curr Opin Obstet Gynecol 6:453-458.
3. Evans MI, Chik L, O'Brien JE, Chen B, Dvorin E, Ayoub M, Krivchenia EL, Ager JW, Johnson MP, Sokol RJ (1995a): MOMs and DADs: Improved specificity and cost effectiveness of biochemical screening for aneuploidy with DADs. Am J Obstet Gynecol 172:1138-1147.
4. Evans MI, Chik L, O'Brien JE, Dvorin E, Johnson MP, Krivchenia EL, Sokol RJ (1995b): Logistic regression generated probability estimates for trisomy 21 outcomes from serum AFP and beta-HCG: Simplification with increased specificity. J Matern Fet Med 5:1-6.
5. Evans MI, O'Brien JE, Dvorin E, Krivchenia EL, Drugan A, Hume RF, Johnson MP (1996): Similarity of insulin dependent diabetics' (IDD) and non-insulin dependent diabetics' (NIDD) levels of beta-hCG and unconjugated estriol with controls: No need to adjust as with AFP. J Soc Gynecol Invest 3:20-22.
6. Hook EB (1981): Rates of chromosomal abnormalities at different gestational ages. Obstet Gynecol 58:292-296.
7. Leporrier N, Herrou M, Leymarie P (1992): Shift of the fetal sex ratio in hCG selected pregnancies at risk for Down syndrome. Prenat Diagn 12:703-704.
8. Lockwood CJ, Lynch L, Ghindini A, Lapinski R, Berkowitz G, Thayer B, Miller WA (1993): The effect of fetal gender on the prediction of Down syndrome by means maternal serum alpha-fetoprotein and ultrasonographic parameters. Am J Obstet Gynecol 169:1190-1197.
9. Merkatz IR, Nitowsky HM, Macri JN, Johnson WE (1984): An association between low maternal serum alpha-fetoprotein and fetal chromosome abnormalities. Am J Obstet Gynecol 148:886-894.
10. O'Brien JE, Dvorin E, Drugan A, Johnson MP, Yaron Y, Evans MI (1997): Ethnic and racial specific variation in multiple marker biochemical screening (MMBS): HCG and uE3 also require separate databases. Obstet Gynecol 89:355-358.
11. Petrikovsky B (1989): Maternal serum alpha fetoprotein concentration and fetal sex. Prenat Diagn 9:449-450.
12. Sowers SG, Reish RL, Burton BK (1983): Fetal sex-related differences in maternal serum alpha-fetoprotein during the second trimester of pregnancy. Am J Obstet Gynecol 146:786-789.
13. Wald NJ, Cuckle HS, Densem JW, Nanchahal K, Royston P, Chard T, Haddow JE, Knight GJ, Palomaki GE, Canick JA (1988): Maternal serum screening for Down's syndrome in early pregnancy. Br Med J [Clin Res] 297:883-887.