3,4-Diaminopyridine-induced impairment in frog motor nerve terminal response to high frequency stimulation

Brain Research

Volumn 789, Issue 2, 1998, Pages 239-244

  Miralles, Francesc ^a   Solsona, Carles ^a  

^a Laboratori Neurbio Cellular I M   (Spain)

Author keywords

3,4 Diaminopyridine; Lambert Eaton myasthenic syndrome treatment; Motor nerve conduction; Multiple sclerosis treatment; Neuromuscular junction; Potassium current; Presynaptic current

Indexed keywords

3 AMINOBENZOIC ACID; 3,4 DIAMINOPYRIDINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; EATON LAMBERT SYNDROME; FROG; MOTOR NERVE; MOTOR NERVE CONDUCTION; NERVE CONDUCTION; NEUROMUSCULAR SYNAPSE; NONHUMAN; POTASSIUM CURRENT; PRESYNAPTIC NERVE; PRIORITY JOURNAL; RANVIER NODE; REFRACTORY PERIOD;

4-AMINOPYRIDINE; ACTION POTENTIALS; ANIMALS; ELECTRIC CONDUCTIVITY; ELECTRIC STIMULATION; MOTOR NEURONS; NEUROMUSCULAR JUNCTION; POTASSIUM; PRESYNAPTIC TERMINALS; RANIDAE; REFRACTORY PERIOD, ELECTROPHYSIOLOGICAL; SODIUM;

EID: 0032513564     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(97)01516-3     Document Type: Article

References (27)

1. + channels, on motor nerve terminals. Br. J. Pharmacol. 93:1988;215-221.
2. Bartschat D.K., Blaustein M.P. Potassium channels in isolated presynaptic nerve terminals from rat brain. J. Physiol. 361:1985;419-440.
3. Benoit E., Corbier A., Dubois J.-M. Evidence for two transient sodium currents in the frog node of Ranvier. J. Physiol. 361:1985;339-360.
4. Bever C.T. The current status of studies of aminopyridines in patients with multiple sclerosis. Ann. Neurol. 36:1994;S118-S121.
5. De Luca C.J., LeFever R.S., McCue M.P., Xenakis A.P. Behavior of human motor units in different muscles during linearly varying contractions. J. Physiol. 329:1982;113-128.
6. Desmedt J.E., Godaux E. Ballistic contractions in man: characteristic recruitment pattern of single motor units of the tibialis anterior muscle. J. Physiol. 264:1977;673-693.
7. + channels in the vasodilator response to bradykinin in the rat heart. Br. J. Pharmacol. 113:1994;954-958.
8. Gundersen C.B., Katz B., Miledi R. The antagonism between botulinum toxin and calcium in motor nerve terminals. Proc. R. Soc. London B Biol. Sci. 216:1982;369-376.
9. Hevron E., David G., Arnon A., Yaari Y. Acetylcholine modulates two types of presynaptic potassium channels in vertebrate motor nerve terminals. Neurosci. Lett. 72:1986;87-92.
10. Hodgkin A.L., Huxley A.F. A quantitative description of membrane current and its application to conduction and excitation in nerve. J. Physiol. 117:1952;500-544.
11. Honmou O., Utzschneider D.A., Rizzo M.A., Bowe C.M., Waxman S.G., Kocsis J.D. Delayed depolarization and slow sodium currents in cutaneous afferents. J. Neurophysiol. 71:1994;1627-1637.
12. Jackson M.B. Presynaptic excitability. Int. Rev. Neurosci. 38:1995;201-251.
13. Kocsis J.D., Waxman S.G. Absence of potassium conductance in central myelinated nerve fibers. Nature. 287:1980;171-184.
14. Lundh H., Nilsson O., Rosén I., Johansson S. Practical aspects of 3,4-diaminopyridine treatment of the Lambert-Eaton myasthenic syndrome. Acta Neurol. Scand. 88:1993;136-140.
15. Mallart A. A calcium-activated potassium current in motor nerve terminals of the mouse. J. Physiol. 368:1985;577-591.
16. A. Mallart, Studies on the ionic properties of presynaptic membranes, in: L.C. Sellin, R. Libelius, S. Thesleff (Eds.), Neuromuscular Junction, Elsevier, Amsterdam, 1989, pp. 161-170.
17. McEvoy K.M., Windebank A.J., Daube J.R., Low P.A. 3,4-diaminopyridine in the treatment of Lambert-Eaton myasthenic syndrome. N. Engl. J. Med. 321:1989;1567-1571.
18. Miralles F., Canti C., Marsal J., Peres J., Solsona C. Zinc ions blocks rectifier potassium channels and calcium activated potassium channels at the frog motor nerve endings. Brain Res. 641:1994;279-284.
19. Miralles F., Marsal J., Peres J., Solsona C. Niflumic acid-induced increase in potassium currents in frog motor nerve terminals: effects on transmitter release. Brain Res. 714:1996;192-200.
20. Miralles F., Solsona C. Activity-dependent modulation of the presynaptic potassium current in the frog neuromuscular junction. J. Physiol. 495:1996;717-732.
21. Peres A., Andrietti F. Computer reconstruction of the spread of excitation in nerve terminals with inhomogeneous channel distribution. Eur. Biophys. J. 13:1986;235-243.
22. Schwarz J.R., Reid G., Bostock H. Action potentials and membrane currents in human node of Ranvier. Pflüg. Arch. 430:1995;283-292.
23. P. Shrager, J.V. Wu, Ionic channels of myelinated axons, in: C. Peracchia (Ed.), Handbook of Membrane Channels: Molecular and Cellular Physiology, Academic Press, San Diego, 1994, pp. 105-113.
24. Smith K.J., Schauf C.L. Size-dependent variation of nodal properties in myelinated nerve. Nature. 293:1981;297-298.
25. Silinsky E.M., Solsona C. Calcium currents at motor nerve endings: absence of effects of adenosine receptor agonists in the frog. J. Physiol. 457:1992;315-328.
26. Tax A.A.A., Denier van der Gon J.J. A model for neural control of gradation of muscle force. Biol. Cybern. 65:1991;227-234.
27. Van del Kloot W., Molgó J. Quantal acetylcholine release at the vertebrate neuromuscular junction. Physiol. Rev. 74:1994;899-991.