Isolation and analysis of two strongly transforming isoforms of the Epstein-Barr-virus(EBV)-encoded latent membrane protein-1 (LMP1) from a single Hodgkin's lymphoma

International Journal of Cancer

Volumn 76, Issue 2, 1998, Pages 194-200

  Mehl, Anja M ^a   Fischer, Nicole ^b   Rowe, Martin ^c   Hartmann, Frank ^b   Daus, Heiner ^a   Trümper, Lorenz ^b   Pfreundschuh, Michael ^c   Müller Lantzsch, Nikolaus ^b   Grässer, Friedrich A ^a  

^a Abteilung Virologie   (Germany)

^b SAARLAND UNIVERSITY   (Germany)

^c CARDIFF UNIVERSITY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CD40 ANTIGEN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERCELLULAR ADHESION MOLECULE 1 ANTIBODY; LATENT MEMBRANE PROTEIN 1; MEMBRANE PROTEIN; UNCLASSIFIED DRUG; VIRUS PROTEIN;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL SURFACE; CELL TRANSFORMATION; CONTROLLED STUDY; EPSTEIN BARR VIRUS; GENE INSERTION; HODGKIN DISEASE; HUMAN; HUMAN CELL; LYMPH NODE BIOPSY; MALE; NASOPHARYNX CARCINOMA; NONHUMAN; POINT MUTATION; PRIORITY JOURNAL; PROTEIN ISOLATION; RAT; REED STERNBERG CELL; SIGNAL TRANSDUCTION;

ADULT; AMINO ACID SEQUENCE; BIOPSY; CELL TRANSFORMATION, NEOPLASTIC; CELL TRANSFORMATION, VIRAL; FIBROBLASTS; GENES, VIRAL; HERPESVIRIDAE INFECTIONS; HERPESVIRUS 4, HUMAN; HODGKIN DISEASE; HUMANS; ISOMERISM; LYMPH NODES; MALE; MOLECULAR SEQUENCE DATA; MUTATION; NF-KAPPA B; PHENOTYPE; STIMULATION, CHEMICAL; TUMOR VIRUS INFECTIONS; VIRAL MATRIX PROTEINS;

EID: 0032513526     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0215(19980413)76:2<194::AID-IJC5>3.0.CO;2-S     Document Type: Article

References (31)

1. BAER, R., BANKIER, A.T. and BIGGIN, M.D., DNA sequence and expression of the B95.8 Epstein-Barr-virus genome. Nature (Loud.), 310, 207-211 (1984).
2. BAICHWAL, V.R. and SUGDEN, B., Transformation of Balb3T3 by the BNLF-1 gene of Epstein-Barr virus. Oncogene, 2,461-467 (1988).
3. BERGER, C., BROUSSET, P., McQUAIN, C. and KNECHT, H., Deletion variants within the NF-kappa-B activation domain of the LMP1 oncogene in acquired immunodeficiency-syndrome-related large-cell lymphomas, in pre-lymphomas and atypical lymphoproliferations. Leuk. Lymphoma, 26, 239-250 (1997).
4. CHEN, C.L., SADLER, R.H., WALLING, D.M., Su, I.J., HSIEH, H.C. and RAAB-TRAUB, N., Epstein-Barr-virus(EBV)-gene expression in EBV-positive peripheral-T-cell lymphomas. J. Virol., 67, 6303-6309 (1993).
5. CHEN, M.L., TSAI, C.N., LIANG, C.L., SHU, C.H., HUANG, C.R., SULITZEANU, D., LIE, S.T. and CHANG, Y.S., Cloning and characterization of the latent membrane protein (LMPI) of a specific Epstein-Barr-virus variant derived from the nasopharyngeal carcinoma in the Taiwanese population. Oncogene, 7, 2131-2140 (1992).
6. CHEUNG, ST., Lo, K.W., LEUNG, S.F., CHAN, W.Y, CHOI, P.H.K., JOHNSON, P.J., LEE, J.C.K. and HUANG, D.P., Prevalence of LMPI deletion variant of Epstein-Barr virus in nasopharyngeal carcinoma and gastric tumors in Hong Kong. Int. J. Cancer, 66, 711-712 (1996).
7. DAWSON, C.W., RICKINSON, A.B. and YOUNG, L.S., Epstein-Barr-virus latent membrane protein inhibits human epithelial-cell differentiation. Nature (Lond.), 344, 777-780 (1990).
8. DOLCETTI, R., ZANCAI, P., DE RE, V., GLOGHINI, A., BIGONI, B., PIVETTA, B., DE VITA, S., CARBONE, A. and BOIOCCHI, M., Epstein-Barr-virus strains with latent-membrane-protein-1 deletions: prevalence in the Italian population and high association with human-immunodeficiency-virus-related Hodgkin's disease. Blood. 89,1723-1729 (1997).
9. ENGERT, A., MARTIN, G., PFREUNDSCHUH, M., AMLOT, P., Hsu, S.M. and THORPE, P., Anti-tumor effects of ricin-A-chain immunotoxins prepared from intact antibodies and Fab' fragments on solid human Hodgkin's-disease tumors in mice. Cancer Res., 50, 2929-2934 (1990).
10. HAMMARSKJÖLD, M.L. and SIMURDA, M.C., Epstein-Barr-virus latent membrane protein transactivates the human-immunodeficiency-virus type-1 long-terminal repeat through induction of NF-kappa-B activity. J. Virol., 66, 6496-6501 (1992).
11. HERBST, H., DALLENBACH, F., HUMMEL, M., NIEDOBITEK, G., PILERI, S. and STEIN, H., Epstein-Barr-virus-DNA and latent-membrane expression in Hodgkin and Reed-Sternberg cells. Proc. nat. Acad. Sci. (Wash.), 88, 4766-4770 (1991).
12. HU, L.F., ZABAROVSKY, E.R., CHEN, F., CAO, S.L., ERNBERG, I., KLEIN, G. and WEINBERG, G., Isolation and sequencing of the Epstein-Barr-virus BNLF1 gene (LMPI) from a Chinese nasopharyngeal carcinoma. J. gen. Virol., 79, 2399-2409 (1991).
13. HUEN, D.S., HENDERSON, S.A., CROOM-CARTER, D. and ROWE, M., The Epstein-Barr-virus latent membrane protein-1 (LMPI) mediates activation of NF-KB and cell-surface phenotype via two effector regions in its carboxy-terminal cytoplasmic domain. Oncogene, 10, 549-560 (1995).
14. KAY, K., IZUMI, K., MOSIALOS, G. and KIEFF, E., The Epstein-Barr-virus-LMP1 cytoplasmic carboxy terminus is essential for B-lymphocyte transformation; fibroblast co-cultivation complements a critical function within the terminal-155 residues. J. Virol., 69, 675-683 (1995).
15. KNECHT, H., BACIIMANN, E., BROUSSET, P., SANDVEJ, K., NADAL, D., BACHMANN, F., ODERMATT, B.F., DELSOL, G. and PALLESEN, G., Deletions within the LMP1 oncogene of Epstein-Barr virus are clustered in Hodgkin's
16. disease and identical to those observed in nasopharyngeal carcinoma. Blood, 82, 2937-2942 (1993).
17. KNECHT, H., McQUAIN, C., MARTIN, J., ROTHENBERGER, S., DREXLER, H.G., BERGER, C., BACHMANN, E., KITTLER, E.L.W., ODERMATT, B.F. and QUESENBERRY, P.J., Expression of the LMP1 oncoprotein in the EBV-negative Hodgkin's-disease cell line L-428 is associated with Reed-Sternberg cell morphology. Oncogene, 13, 947-953 (1996).
18. Li, S.N., CHANG, Y.S. and LIU, S.T., Effect of a 10-amino-acid deletion on the oncogenic activity of latent membrane protein 1 of Epstein-Barr virus. Oncogene, 12, 2129-2135 (1996).
19. MEGGETTO, F., BROUSSET, P., SELVES, J., DELSOL, G. and MARIAME, B., Reed-Stemberg cells and "bystander" lymphocytes in lymph nodes affected by Hodgkin's disease are infected with different strains of Epstein-Barr virus. J. Virol., 71, 2547-2549 (1997).
20. MITCHELL, T. and SUGDEN, B., Stimulation of NF-KB-mediated transcription by mutant derivates of the latent membrane protein of Epstein-Barr virus. J. Virol., 69, 2968-2976 (1995).
21. PALLESEN, G., HAMILTON-DUTOIT, S.J., ROWE, M. and YOUNG, L.S., Expression of Epstein-Barr-virus latent gene products in tumour cells of Hodgkin's disease. Lancet, 337, 320-322 (1991).
22. PENG, M. and LUNDGREN, E., Transient expression of the Epstein-Barr-virus LMP1 gene in B-cell chronic lymphocytic leukemia cells, T cells and hematopoietic cell lines: cell-type-independent induction of CD23, CD21 and ICAM-1. Leukemia, 7, 104-112 (1993).
23. RICKINSON, A.B. and KIEFF, E., Epstein-Barr virus. In: B.N. Fields, D.M. Knipe, P.M. Howley, et al. (eds). Fields Virology, Third edition. Lippincott-Raven Publishers, Philadelphia (1995).
24. ROTHENBERGER, S., BACHMANN, E., BERGER, C., McQUAIN, C., ODERMATT, B. and KNECHT, H., Natural 30-base-pair and 69-base-pair deletion variants of the LMP1 oncogene do stimulate NF-kappa-B-mediated transcription. Oncogene, 14, 2123-2126 (1997).
25. ROWE, M., EVANS, H.S., YOUNG, L. and RICKINSON, A.B., Monoclonal antibodies to the latent membrane protein of Epstein-Barr virus reveal heterogeneity of the protein and inducible expression in virus-transformed cells. J. gen. Virol., 68, 1575-1586 (1987).
26. SANDBERG, M., HAMMERSCHMIDT, W. and SUGDEN, B., Characterisation of LMPl's association with TRAF1, TRAF2 and TRAF3. J. Virol., 71, 4649-4656 (1997).
27. SANDVEJ, K., GRATAMA, J.W., MUNCH, M., ZHOU, X.G., BOLIIUIS, R.L.H., ANDRESEN, B.S., GREGERSEN, N. and HAMILTON-DUTOIT, S., Sequence analysis of the Epstein-Barr-virus(EBV) latent-membrane-protein-1 gene and promoter region: identification of four variants among wild-type EBV isolates. Blood, 90, 323-330 (1997).
28. TROMPER, L.H. and 12 OTHERS, Single-cell analysis of Hodgkin and Reed-Sternberg cells: molecular heterogeneity of gene expression and p53 mutations. Blood, 81, 3097-3115 (1993).
29. YAO, Q.Y., TIERNEY, R.J., CROOM-CARTER, D., DUKERS, D., COOPER, G.M., ELLIS, C.J., ROWE, M. and RICKINSON, A.B., Frequency of multiple Epstein-Barr-virus infections in T-cell immunocompromised individuals. J. Virol., 70, 4884-4894 (1996).
30. YOUNG, L., ALIFIERI, C., HENNESSY, K., EVANS, H., O'HARA, C., ANDERSON, K.C., RITZ, J., SHAPIRO, R.S., RICKINSON, A.B., KIEFF, E. and COHEN, J.I., Expression of the Epstein-Barr-virus-transformalion-associated genes in tissues of patients with EBV lymphoproliferative disease. New Engl. J. Med., 321, 1080-1085 (1989).
31. YOUNG, L.S., DAWSON, C.W., ROONEY, C.M. and CLARK, D., Epstein-Barr-virus-gene expression in nasopharyngeal carcinoma. J. gen. Virol., 69, 1051-1069 (1980).