Directed ortho Metalation - Cross coupling connections. Total synthesis of Amaryllidaceae alkaloids buflavine and 8-O-demethylbuflavine

Tetrahedron Letters

Volumn 39, Issue 11, 1998, Pages 1325-1326

  Patil, Prakash A ^a   Snieckus, Victor ^b  

^a CIDtech Research Inc   (Canada)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ALKALOID;

ARTICLE; CHEMICAL REACTION; SYNTHESIS;

EID: 0032510436     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(98)00003-3     Document Type: Article

References (8)

1. 1. Viladomat, F.; Bastida, J.; Codina, C.; Campbell, W.E.; Mathee, S. Phytochemistry 1995, 40, 307.
2. 2. a) Ishida, Y.; Sasaki, Y.; Kimura, Y.; Watanabe, K. J. Pharmacobiodyn. 1985, 8, 917; Chem. Abstr. 1986, 104, 45660.
3. 2. a) Ishida, Y.; Sasaki, Y.; Kimura, Y.; Watanabe, K. J. Pharmacobiodyn. 1985, 8, 917; Chem. Abstr. 1986, 104, 45660.
4. b) Ishida, Y.; Watanabe, K.; Kobayashi, S.; Kihara, M. Chem. Pharm. Bull. Jpn. 1977, 25, 1851.
5. 3. Cuevas, J.-C.; Patil, P.; Snieckus, V. Tetrahedron Lett. 1989, 43, 5841.
6. 1 by twenty years, the present work may arguably claim the first total synthesis of this class of natural products.
7. 3 to give 5 in 75% yield.
8. 13C NMR and HRMS) and analytical data in accordance with their assigned structures.