Acetamidine lysine derivative, N- (5 (S) -amino-6,7-dih ydroxyheptyl) -ethanimidamide dihydrochloride: A highly selective inhibitor of human inducible nitric oxide synthase

Journal of Medicinal Chemistry

Volumn 41, Issue 6, 1998, Pages 776-777

  Ann Hallinan, E ^a   Tsymbalov, Sofya ^a   Finnegan, Patricia M ^a   Moore, William M ^a   Jerome, Gina M ^a   Currie, Mark G ^a   Pitzele, Barnett S ^a  

^a Departments of Chemistry and Inflammatory Diseases Research   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ENZYME INHIBITOR; FATTY ALCOHOL; IMINE; INDUCIBLE NITRIC OXIDE SYNTHASE; N (5 AMINO 6,7 DIHYDROXYHEPTYL)ETHANIMIDAMIDE; N-(5-AMINO-6,7-DIHYDROXYHEPTYL)ETHANIMIDAMIDE; NITRIC OXIDE SYNTHASE; NOS2A PROTEIN, HUMAN;

ARTICLE; BIOSYNTHESIS; CHEMISTRY; DRUG ANTAGONISM; DRUG EFFECT; ENZYME INDUCTION; HUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; STEREOISOMERISM; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ENZYME INDUCTION; ENZYME INHIBITORS; FATTY ALCOHOLS; HUMANS; IMINES; MAGNETIC RESONANCE SPECTROSCOPY; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE II; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0032510239     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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15. No standardization of measuring iNOS inhibition has occurred in this area of research. Variation in the source of NOS, NOS purity, the presence or absence of cofactors, concentration of cofactors, presence or absence of protease inhibitors, time of exposure of inhibitor to enzyme, reaction time, composition, and pH of buffer containing enzyme all contribute to the wide variability in reported enzyme inhibitor potency. Moore, P. K; Handy, R. L. C. Selective Inhibitors of Neuronal Nitric Oxide Synthase-Is no NOS REally good NOS for the Nervous System? Trends Pharmacol. 1997, 18, 203-311.