Design, synthesis, and biological evaluation of conformationally constrained aci-reductone mimics of arachidonic acid

Journal of Medicinal Chemistry

Volumn 41, Issue 4, 1998, Pages 420-427

  Hopper, Allen T ^a   Witiak, Donald T ^b   Ziemniak, John ^a  

^a OXIS International Inc   (United States)

^b UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 AMINO 1 (3 TRIFLUOROMETHYLPHENYL) 2 PYRAZOLINE; 3,4 DIHYDROXY 5 [4 (2 HEXENYLPHENYL) 3 BUTENYL] 2(5H) FURANONE; ACETYLSALICYLIC ACID; ALPHA TOCOPHEROL; ANTIOXIDANT; ARACHIDONIC ACID DERIVATIVE; CARBON TETRACHLORIDE; INDOMETACIN; LEAD; LIPOXYGENASE INHIBITOR; PROSTAGLANDIN SYNTHASE INHIBITOR; UNCLASSIFIED DRUG; ZILEUTON;

ANIMAL CELL; ANTIOXIDANT ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG CONFORMATION; DRUG DESIGN; DRUG SYNTHESIS; LIPID PEROXIDATION; LIVER MICROSOME; LUNG ALVEOLUS MACROPHAGE; NONHUMAN; RAT;

ANIMALS; ANTIOXIDANTS; ARACHIDONATE 5-LIPOXYGENASE; ARACHIDONIC ACID; CELL LINE, TRANSFORMED; CELL NUCLEUS; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITORS; CYCLOOXYGENASE INHIBITORS; DRUG DESIGN; INDICATORS AND REAGENTS; ISOENZYMES; LIPOPOLYSACCHARIDES; LIPOXYGENASE INHIBITORS; MACROPHAGES, PERITONEAL; MALONDIALDEHYDE; MEMBRANE PROTEINS; MODELS, MOLECULAR; MOLECULAR CONFORMATION; MOLECULAR STRUCTURE; NF-KAPPA B; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; RATS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0032510071     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm970034q     Document Type: Article

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