Trimethyl orthoformate as a highly selective mono-C-methylating agent for arylacetonitriles

Journal of Organic Chemistry

Volumn 63, Issue 25, 1998, Pages 9540-9544

  Selva, Maurizio ^a   Tundo, Pietro ^a  

^a CA' FOSCARI UNIVERSITY OF VENICE   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

FORMIC ACID DERIVATIVE; IBUPROFEN; KETOPROFEN; NAPROXEN; NITRILE;

ALKYLATION; ARTICLE; CHEMICAL REACTION; DRUG STRUCTURE; DRUG SYNTHESIS; METHYLATION; REACTION ANALYSIS; STRUCTURE ANALYSIS;

EID: 0032509371     PISSN: 00223263     EISSN: None     Source Type: Journal    
DOI: 10.1021/jo980914s     Document Type: Article

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27. Unless otherwise indicated, the product % indicated in Table 1 as well as those of Tables 2 and 3 represents the % areas of the corresponding gas-chromatographic peaks. However, when authentic samples of compounds 1a-4a were compared to tetradecane as a standard, very similar GC-response factors were observed for them.
28. 2CN]} x 100, where % is defined in ref 24.
29. 3)-COOH (coming from the hydrolysis of 2) should bo observed, but we never detected it.
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