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note
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Variation in the choice of the silyl protecting group was due to incompatibilities caused by the lack of reactivity of the silylating reagents used, β-elimination of the silyloxy group, or difficulties in achieving TBAF-mediated desilylation (see Supporting Information).
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For recent examples of alternative approaches to hydroxy- and alkoxy-substituted benzofurans, see: (a) Novák, L.; Kovács, P.; Pirok, G.; Kolonits, P.; Hanania, M.; Donáth, K.; Szántay, C. Tetrahedron 1997, 53, 9789-9798. (b) Engler, T. A.; Gfesser, G. A.; Draney, B. W. J. Org. Chem. 1995, 60, 3700-3706.
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For recent examples of alternative approaches to hydroxy- and alkoxy-substituted benzofurans, see: (a) Novák, L.; Kovács, P.; Pirok, G.; Kolonits, P.; Hanania, M.; Donáth, K.; Szántay, C. Tetrahedron 1997, 53, 9789-9798. (b) Engler, T. A.; Gfesser, G. A.; Draney, B. W. J. Org. Chem. 1995, 60, 3700-3706.
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Phenolic benzopyrans have also been recognized as structural units critical to the potency of synthetic dopamine agonists: Neirabeyeh, M. A.; Reynaud, D.; Podona, T.; Ou, L.; Perdicakis, C.; Coudert, G.; Guillaumet, G.; Pichat, L.; Gharib, A.; Sarda, N. Eur. J. Med. Chem. 1991, 26, 497-504.
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