Aflatoxin B1-induced suppression of nitric oxide production in murine peritoneal macrophages

Journal of Toxicology and Environmental Health - Part A

Volumn 55, Issue 7, 1998, Pages 517-530

  Moon, Eun Yi ^a   Han, Jae Jin ^a   Rhee, Dong Kwon ^b   Pyo, Suhkneung ^b  

^a DongWha Pharm Ind Co   (South Korea)

^b Sungkyunkwan University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

AFLATOXIN B1; LIPOPOLYSACCHARIDE; MESSENGER RNA; NITRIC OXIDE; NITRIC OXIDE SYNTHASE;

ANIMAL CELL; ARTICLE; BACTERIUM; CELL FUNCTION; CONTROLLED STUDY; CYTOTOXICITY; ENZYME ACTIVITY; HOST RESISTANCE; IMMUNE RESPONSE; LYMPHOCYTE; MESSENGER RNA SYNTHESIS; MOUSE; NONHUMAN; PERITONEUM MACROPHAGE; PRIORITY JOURNAL; PROTEIN SYNTHESIS; TUMOR;

AFLATOXIN B1; ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; LIPOPOLYSACCHARIDES; MACROPHAGES, PERITONEAL; MICE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE II; RNA, MESSENGER;

ANIMALIA; BACTERIA (MICROORGANISMS); MURINAE;

EID: 0032509085     PISSN: 15287394     EISSN: 10872620     Source Type: Journal    
DOI: 10.1080/009841098158313     Document Type: Article

References (43)

1. Adams, D. O., and Hamilton, T. A. 1984. The cell biology of macrophage activation. Annu. Rev. Immunol. 2:283-318.
2. Blackford, J. A., Jr., Jones, W., Dey, R. D., and Castranova, V. 1997. Comparison of inducible nitric oxide synthase gene expression and lung inflammation following intratracheal instillation of silica, coal, carbonyl iron, or titaninm dioxide in rats. J. Toxicol. Environ. Health 51:203-218.
3. Bodine, A. B., Fisher, S. F., and Gangjee, S. 1984. Effect of aflatoxin B1and bovine lymphocytes. J. Dairy Sci. 67:110-114.
4. Bredt, D. S., and Snyder, S. H. 1994. Nitric oxide: A physiologic messenger molecule. Annu. Rev. Biochem. 63:175-195.
5. Carl, L. M., Pin-Yu, P., Cindy, A. S., and Stefanie, N. V. 1994. Taxol provide a second signal for murine macrophage t umoricidal activity. J. Immunol. 152:825-831.
6. Carmichael, J., DeGraff, W. G., Gazdar, A. F., Minna, J. D., and Mitchell, J. B. 1987. Evaluation of a tetrazolium-based semiautomated colorimetric assay: Assessment of chemosensitivity testing. Cancer Res. 47:936-942.
7. Chomczynski, P., and Sacchi, N. 1987. Single-step method isolation by rapid guanidium thio-cyanate-phenol-chloroform extraction. Anal. Biochem. 162:156-159.
8. Corrier, D. E. 1991. Mycotoxicosis: Mechanisms of immunosuppression. Vet. Immunol. Immunopathol. 30:73-87.
9. Cysewski, S. J., Wood, R. L., Pier, A. C., and Baetz, A. L. 1978. Effects of aflatoxin on the development of acquired i mmunity to swine erysipelas. Am. J. Vet. Res. 39:445-448.
10. Ding, A. H., Nathan, C. F., and Stuehr, D. J. 1988. Release of reactive nitrogen intermediates and reactive oxygen intermediates from mouse peritoneal macrophages. Comparison of activating cytokines and evidence for independent production. J. Immunol. 141:2407-2412.
11. Dugyala, R. R., Kim, Y. W., and Sharma, R. P. 1994. Effects of aflatoxin B1and T-2 toxin on the granulocyte-macrophage progenitor cells in mouse bone marrow cultures. Immunopharmacology 27:57-65.
12. Flick, D. A., and Gifford, G. E. 1984. Comparison of in vitro cell cytotoxicity assays for tumor necrosis factor. J. Immunol. 68:167-175.
13. Inverson, F., Campbell, J., Clayson, D., Hierlihy, S., Labossiere, E., and Hayward, S. 1987. Effect of antioxidants on a flatoxin-induced hepatic tumors in rats. Cancer Lett. 34:13 9-144.
14. Jakab, G. J., Hmieleski, R. R., Zarba, A., Hemenway, D. R., and Groopman, J. D. 1994. Respiratory aflatoxicosis: Suppression of pulmonary and systemic host defenses in rats and mice. Toxicol. Appl. Pharmacol. 125:198-205.
15. Klimetzek, V., and Remold, H. G. 1980. The murine bone marrow macrophage, a sensitive indicator cell for murine migration inhibitory factor and a new method for their harvest. Cell. Immun. 53: 257-266.
16. Knowles, R. G., and Moncada, S. 1994. Nitric oxide synthesis in mammals. Biochemistry 298:249-258.
17. Laemmli, U. K. 1970. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227:680-685.
18. Lancaster, J. R., Jr., and Hibbs, J. B., Jr. 1990. EPR demonstration of iron-nitrosyl complex formation by cytotoxic activated macrophages. Proc. Natl. Acad. Sci. USA 87:1223-1227.
19. Mistry, K. J., Krishna, M., and Bhattacharya, R. K. 1995. Signal transduction mechanism in response to aflatoxin B1exposure: Phosphatidylinositol metabolism. Chem. Biol. Interact. 98:145-152.
20. Nathan, C. F. 1992. Nitric oxide as a secondary product of mammalian cells. FASEBJ. 6:3051-3064.
21. Neldon-Ortiz, D. L., and Qureshi, M. A. 1991. Direct and microsomal activated aflatoxin B1exposure and its effects on turkey peritoneal macrophage functions in vitro. Toxicol. Appl. Pharmacol. 109:432-442.
22. Nose, H., Imazeki, F., Ohto, M., and Omata, M. 1993. p53 Gene mutation and 17p allelic deletion in hepatocellular carcinoma from Japan. Cancer 72:355-360.
23. Paul, P. S., Johnson, D. W., Mirocha, C. J., and Soper, B. S. 1977. In vitro stimulation of phytomitogen and specific antigen l ymphocyte responses by aflatoxin. Am. J. Vet. Res. 38:2033-2035.
24. Pyo, S., Gangemi, J. D., Ghaffer, A., and Mayer, E. P. 1991. Poly I:C-induced anti-herpes simplex virus type I activity in inflammatory macrophages is mediated by induction of interferon-p. J. Leukocyte Biol. 50:479-487.
25. Radomski, M. W., Palmer, R. M. J., and Moncada, S. 1990. Glucocorticoids inhibit the expression of an inducible, but not the constitutive, nitric oxide synthase in vascular endothelial cells. Proc. Natl. Acad. Sci. USA 87:10043-10047.
26. Raisuddin, S., Zaidi, S. I. A., Singh, K. P., and Ray, P. K. 1991. Effect of subchronic aflatoxin exposure on growth and progression of Ehrlich's ascites tumor. Drug Chem. Toxicol. 14:185-206.
27. Raissudin, S., Singh, K. P., Zaidi, S. I. A., and Ray, P. K. 1994. Immunostimulating effects of protein A in immunosuppressed aflatoxin-intoxicated rats. Int. J. Immunopharm. 16:977-984.
28. Reddy, R. V., and Sharma, R. P. 1989. Effects of aflatoxin B1on murine lymphocytic functions. Toxicology 54:31-44.
29. Reddy, R. V., Taylor, M. J., and Sharma, R. P. 1987. Studies of immune function of CD-1mice exposed to aflatoxin B1. Toxicology 43:123-132.
30. Richard, J. L., Thurston, J. R., and Pier, A. C. 1978. Effects of mycotoxins on immunitiy. In Toxins: Animal, plant and microbial, ed. P. Rosenberg, pp. 801-817. New York: Pergamon Press.
31. Robens, J. F., and Richard, J. L. 1992. Aflatoxins in animal and human health. Rev. Environ. Contam. Toxicol. 127:69-94.
32. Savel, H., Forsynth, B., Schaeffer, W., and Cordella, T. 1970. Effect of aflatoxin B1upon phytohemagglutinin-transformed human l ymphocytes. Proc. Soc. Exp. Biol. Med. 134:112-115.
33. Schmidt, H. H. W., Warner, T. D., Nakane, M., Forstermann, U., and Murad, F. 1992. Regulation and subcellular l ocation of nitrogen oxide synthases in Raw 264.7 macrophages. Mol. Pharmacol. 41:615-624.
34. Soman, N. R., and Wogan, G. N. 1993. Activation of the c-Ki-ras oncogene in aflatoxin B1-induced hepatocellular carcinoma and adenoma in the rat: Detection by denaturing gradient gel electrophoresis. Proc. Natl. Acad. Sci. USA 90:2045-2049.
35. Stossel, T. P. 1973. Evaluation of opsonic and leukocyte function with a spectrophotometric test in patients with infection and with phagocytic disorder. Blood 42:121-130.
36. Stuehr, D. J., and Marletta, M. A. 1985. Mammalian nitrate biosynthesis: Mouse macrophages produce nitrite and nitrate in response to Escherichia coli lipopolysaccharide. Proc. Natl. Acad. Sci. USA 82:7738-7742.
37. Swenson, D. H., Miller, J. A., and Miller, E. C. 1975. The reactivity and carcinogenicity of aflatoxin B1-2,3-dichloride, a model for the putative 2,3-oxide metabolite of aflatoxin B1. Cancer Res. 35:3811-3823.
38. Thomas, P. S. 1980. Hybridization of denatured RNA and DNA fragments transferred to nitrocellulose. Proc. Natl. Acad. Sci. USA 77:5201-5209.
39. Vodovotz, Y., Bogdan, C., Paik, J., Xie, Q. W., and Nathan, C. 1993. Mechanisms of suppression of macrophage nitric oxide release by transforming growth factor-B. J. Exp. Med. 178:605-613.
40. Walsh, C. J., Bodine, A. B., and Scott, T. R. 1991. Co-mitogenic assay for assessing the effects of aflatoxin B1on interleukin-1production in bovine macrophages. Drug Dev. Res. 24:157-166.
41. Xie, Q., Cho, H. J., Calaycay, J., Mumford, R. A., Swiderek, K. M., Lee, T. D., Ding, A., Troso, T., and Nathan, C. 1992. Cloning and characterization of inducible nitric oxide synthase from mouse macrophages. Science 256:225-228.
42. Xie, Q., Kashiwabara, Y., and Nathan, C. 1994. Role of transcription factor NF-k B/Rel in induction of nitric oxide synthase. J. Biol. Chem. 269:4705-4708.
43. Zhang, X., Laubach, V. E., Alley, E. W., Edwards, K. A., Sherman, P. A., Russell, S. W., and Murphy, W. J. 1996. Transcriptional basis for hyporesponsiveness of the human inducible nitric oxide synthase gene to lipopolysaccharide. J. Leukocyte Biol. 59:575-585.