Should inhaled anticholinergics be added to β2 agonists for treating acute childhood and adolescent asthma? A systematic review

BMJ

Volumn 317, Issue 7164, 1998, Pages 971-977

  Plotnick, Laurie H ^a   Ducharme, Francine M ^a  

^a MONTREAL CHILDREN S HOSPITAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

BETA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; CHOLINERGIC RECEPTOR BLOCKING AGENT;

ADOLESCENT; ARTICLE; ASTHMA; CHILD; CLINICAL TRIAL; CONTROLLED STUDY; DISEASE SEVERITY; DRUG SAFETY; HOSPITAL ADMISSION; HUMAN; INHALATIONAL DRUG ADMINISTRATION; LUNG FUNCTION TEST; MAJOR CLINICAL STUDY; META ANALYSIS; NAUSEA; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; TREMOR; VOMITING;

ACUTE DISEASE; ADMINISTRATION, INHALATION; ADOLESCENT; ADRENERGIC BETA-ANTAGONISTS; ASTHMA; CHILD; CHILD, PRESCHOOL; CHOLINERGIC ANTAGONISTS; CLINICAL PROTOCOLS; DOSE-RESPONSE RELATIONSHIP, DRUG; FORCED EXPIRATORY VOLUME; HUMANS; RANDOMIZED CONTROLLED TRIALS; TREATMENT OUTCOME;

EID: 0032505552     PISSN: 09598138     EISSN: 14685833     Source Type: Journal    
DOI: 10.1136/bmj.317.7164.971     Document Type: Article

References (40)

1. British Medical Association. Asthma: A follow up statement from an international paediatric asthma consensus group. Arch Dis Child 1992; 67: 240–248.
2. Warner JO, Gotz M, Landau LI, Levison H, Milner AD, Pedersen S, et al. Management of asthma: A consensus statement. Arch Dis Child 1989; 64: 1065–1079.
3. Guidelines on the management of asthma. Thorax 1993; 48: 1–24.
4. Rachelefsky GS, Warner JO. International consensus on the management of pediatric asthma: A summary statement. Pediatr Pulmonol 1993; 15: 125–127.
5. Mitchell EA. Consensus on acute asthma management in children. Ad Hoc Paediatric Group. N Z Med J 1992; 105: 353–355.
6. Ernst P, Fitzgerald JM, Spier S. Canadian asthma consensus conference summary of recommendations. Can Respir J 1996; 3: 89–100.
7. Tal A, Levy N, Bearman JE. Methylprednisolone therapy for acute asthma in infants and toddlers: A controlled clinical trial. Pediatrics 1990; 86: 350–356.
8. Scarfone RJ, Fuchs SM, Nager AL, Shane SA. Controlled trial of oral prednisone in the emergency department treatment of children with acute asthma. Pediatrics 1993; 92: 513–518.
9. Svedmyr N. Fenoterol: A beta2-adrenergic agonist for use in asthma pharmocology, pharmokinetics, clinical efficacy and adverse effects. Pharmacotherapy 1985; 5: 109–126.
10. Sears MR. Clinical application of beta-agonists. Practical Allergy Immunol 1992; 7: 98–100.
11. Gross NJ. Ipratropium bromide. N Engl J Med 1988; 8: 486–494.
12. Silverman M. The role of anticholinergic antimuscarinic bronchodilator therapy in children. Lung 1990; 168: 304–309.
13. Chapman K. An international perspective on anticholinergic therapy. Am J Med 1996; 100: 2–4.
14. Guill MF, Maloney MJ, DuRant RH. Comparison of inhaled metaproterenol, inhaled atropine sulfate, and their combination in treatment of children with acute asthma. Ann Allergy 1987; 59: 367–371.
15. Cook JJ, Fergusson DM, Dawson KP. Ipratropium and fenoterol in the treatment of acute asthma. Pharmatherapeutica 1985; 4: 383–386.
16. Reisman J, Galdes-Sebalt M, Kazim F, Canny G, Levison H. Frequent administration by inhalation of salbutamol and ipratropium bromide in the initial management of severe acute asthma in children. J Allergy Clin Immunol 1988; 81: 16–20.
17. Watson WTA, Becker AB, Simons FER. Comparison of ipratropium solution, fenoterol solution, and their combination administered by nebulizer and face mask to children with acute asthma. J Allergy Clin Immunol 1988; 82: 1012–1018.
18. Osmond MH, Klassen TP. Efficacy of ipratropium bromide in acute childhood asthma a meta-analysis. Acad Emerg Med 1995; 2: 651–656.
19. Schuh S, Johnson DW, Callahan S, Canny G, Levison H. Efficacy of frequent nebulized ipratropium bromide added to frequent high-dose albuterol therapy in severe childhood asthma. J Pediatr 1995; 126: 639–645.
20. Qureshi FA, Zaritsky A, Lakkis H. Efficacy of nebulized ipratropium in severe asthmatic children. Ann Emerg Med 1997; 29: 205–211.
21. Ducharme FM, Davis GM. Randomized controlled trial of ipratropium bromide and frequent low doses of salbutamol in the treatment of mild and moderate acute asthma. Pediatr Res 1995; 37: 136A.
22. Peto R, Collins R, Gray R. Large-scale randomized evidence: large, simple trials and overviews of trials. J Clin Epidemiol 1995; 48: 23–40.
23. Sackett DL. Applying overviews and meta-analyses at the bedside. J Clin Epidemiol 1995; 48: 61–66.
24. Greenhalgh T. Papers that summarize other papers (systematic reviews and meta-analyses). BMJ 1997; 315: 672–675.
25. Jadad AR, Moore RA, Carroll D, Jenkinson C, Reynolds DJ, Gavaghan DJ, et al. Assessing the quality of reports of randomized controlled trials: is blinding necessary? Control Clin Trials 1995; 134: 1–12.
26. Greenland S, Robins JM. Estimation of a common effect parameter from sparse follow-up data. Biometrics 1985; 41: 55–68.
27. DerSimonian R, Laird N. Meta-analysis in clinical trials. Control Clin Trials 1986; 7: 177–188.
28. Olkin I. Statistical and theoretical considerations in meta-analysis. J Clin Epidemiol 1995; 48: 133–146.
29. Hasselblad V, Hedges LV. Meta-analysis of screening and diagnostic tests. Psychol Bull 1995; 117: 167–178.
30. Robins J, Breslow N, Greenland S. Estimators of the Mantel-Haenszel variance consistent in both sparse data and large-strata limiting models. Biometrics 1986; 42: 311–323.
31. Egger M, Smith GD, Schneider M, Minder C. Bias in meta-analysis detected by a simple, graphical test. BMJ 1997; 315: 629–634.
32. Beck R, Robertson C, Galdès-Sebaldt M, Levison H. Combined salbutamol and ipratropium bromide by inhalation in the treatment of severe acute asthma. J Pediatr 1985; 107: 605–608.
33. Phanichyakam P, Kraisarin C, Sasisakulporn C. Comparison of inhaled terbutaline and inhaled terbutaline plus ipratropium bromide in acute asthmatic children. Asian Pac J Allergy Immunol 1990; 8: 45–48.
34. Warner JO. Asthma: A follow up statement from an international paediatric asthma consensus group. Arch Dis Child 1992; 67: 240–248.
35. Khan KS, Daya S, Jahad AR. The importance of quality of primary studies in producing unbiased systematic reviews. Arch Intern Med 1996; 156: 661–666.
36. Stern JM, Simes RJ. Publication bias: evidence of delayed publication in a cohort study of clinical research projects. BMJ 1997; 315: 640–645.
37. Payne SM, Donahue C, Rappo P, McNamara JJ, Bass J, First L, et al. Variations in pediatric pneumonia and bronchitis/asthma admission rates. Is appropriateness a factor? Arch Pediatr Adolesc Med 1995; 149: 162–169.
38. Homer CJ, Szilagyi P, Rodewald L, Bloom SR, Greenspan P, Yazdgerdi S, et al. Does quality of care affect rates of hospitalization for childhood asthma? Pediatrics 1996; 98: 18–23.
39. Cook DJ, Guyatt GH, Ryan G, Clifton J, Buckingham L, Willan A, et al. Should unpublished data be included in meta-analyses? Current convictions and controversies. JAMA 1993; 269: 2749–2753.
40. Sim I, Hlatky MA. Growing pains of meta-analysis. BMJ 1996; 313: 702–703.