Production of artemisinin by shoot cultures of Artemisia annua L. in a modified inner-loop mist bioreactor

Plant Science

Volumn 135, Issue 2, 1998, Pages 211-217

  Liu, Chun Zhao ^a   Wang, Yu Chun ^a   Guo, Chen ^a   Ouyang, Fan ^a   Ye, He Chun ^b   Li, Guo Feng ^b  

^a Chinese A   (China)

^b INSTITUTE OF BOTANY   (China)

Author keywords

Artemisia annua L.; Artemisinin; Misting cycle; Modified inner loop mist bioreactor; Shoot culture

Indexed keywords

ARTEMISIN; MEDICINAL PLANT;

ARTICLE; BIOREACTOR; DRUG MANUFACTURE; DRUG SYNTHESIS; MALARIA; NONHUMAN; PLANT GROWTH;

ARTEMISIA ANNUA;

EID: 0032504174     PISSN: 01689452     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-9452(98)00086-7     Document Type: Article

References (31)

1. Klayman D.L. Qinghaosu (artemisinin): an antimalarial drug from China. Science. 228:1985;1049-1055.
2. Luo X.D., Shen CC. The chemistry, pharmacology and clinical applications of Qinghaosu (artemisinin) and its derivatives. Med. Res. Rev. 7:1987;29-52.
3. Paniego N.B., Giulietti A.M. Artemisia annua L.: dedifferentiated and differentiated cultures. Plant Cell Tiss. Org. Cult. 36:1994;163-168.
4. Xu X.X., Zhu J., Hung D.Z., Zhou W.S. Total synthesis of arteannuin and deoxyarteannuin. Tetrahdron. 42:1986;819-828.
5. Avery M.A., Chong W.K.M., Jennings-White C. Stereoselective total synthesis of (+)-artemisinin, the antimalarial constituent of Artemisia annua L. J. Am. Chem. Soc. 114:1992;974-979.
6. Avery M.A., Jennings-White C., Chong W.K.M. The total synthesis of (+)-artemisinin and (+)-9-desmethylartemisinin. Tetrahdron Lett. 28:1987;4629-4632.
7. Ravindranathan T., Anil K.M., Menon R., Hiremath S.V. Stereo-selective synthesis of artemisinin. Tetrahdron Lett. 31:1990;755-758.
8. Schmid G., Hofheinz W. Total synthesis of Qinghaosu. J. Am. Chem. Soc. 105:1983;624-625.
9. Nair M.S.R., Acton N., Klayman D.L., Kendric K., Basile D.V., Mante S. Production of artemisinin in tissue culture of Artemisia annua. J. Nat. Prod. 49:1986;504-507.
10. He X.C., Zeng M.Y., Li G.F., Liang Z. Callus induction and regeration of plantlets from Artemisia annua and changes of Qinghaosu contents. Acta Botanica Sinica. 25:1983;87-90.
11. Tawfiq N.K., Anderson L.A., Roberts M.F., Phillipson J.D., Bray D.H., Warhurst D.C. Antiplasmodial activity of Artemisia annua plant cell cultures. Plant Cell Rep. 8:1989;425-428.
12. Fulzzle D.P., Sipahimalani A.T., Heble M.R. Tissue culture of Artemisia annua: organogenesis and artemisinin production. Phytother. Res. 5:1991;149-153.
13. Woerdenbag H.J., Jos F.J., Win V.U., Niesko P., Malingre T.M., Alfermann A.W. Production of the new antimalarial drug artemisinin in shoot cultures of Artemisia annua L. Plant Cell Tiss. Org. Cult. 32:1993;247-257.
14. Ferreira J.F.S., Janick J. Roots as an enhancing factor for the production of artemisinin in shoot cultures of Artemisia annua. Plant Cell Tiss. Org. Cult. 44:1996;211-217.
15. Paniego N.B., Giulietti A.M. Artemisinin production by Artemisia annua L.-transformed organ cultures. Enzyme Microb. Technol. 18:1996;526-530.
16. Qin M.B., Li G.Z., Yun Y., Ye H.C., Li G.F. Induction of hairy root from Artemisia annua with Agrobacterium rhizogenes and its culture in vitro. Acta Botanica Sinica. 36:1994;165-170.
17. Weathers P.J., Cheetham R.D., Follansbee E., Teoh H. Artemisinin production by transformed roots of Artemisia annua. Biotechnol. Letts. 16:1994;1281-1286.
18. Cai G.Q., Li G.Z., Ye H.C., Li G.F. Hairy root culture of Artemisia annua L. by plasmid transformation and biosynthesis of artemisinin. Chin. J. Biotech. 11:1995;315-320.
19. Liu C.Z., Wang Y.C., Ouyang F., Ye H.C., Li G.F. Production of artemisinin by hairy root cultures of Artemisia annua L. Biotech. Lett. 19:1997;927-929.
20. Weathers P.J., Cheetham R.D., Giles K.L. Dramatic increases in shoot number and lengths for Musa, Cordyline and Nephrylepsis using nutrient mists. Acta Hort. 230:1988;39-44.
21. Fox J.L. Plants thrive in ultrasonic mists. Biotechnology. 6:1988;361.
22. Weathers P.J., Giles K.L. Regeneration of plants using nutrient mist culture. In Vitro. 24:1988;727-732.
23. Kurata K., Ibaraki Y., Goto E. System for micropropagation by nutrient mist supply. ASAE. 34:1991;621-624.
24. Dilorio A.A., Cheetham R.D., Weathers P.J. Growth of transformed roots in a nutrient mist bioreactor. Appl. Microb. Biotechnol. 37:1992;457-462.
25. Buer C.S., Correll M.J., Smith T.C., Towler M.J., Weather P.J., Nadler M., Seaman J., Walcerz D. Development of a nontoxic acoustic window nutrient-mist bioreactor and development growth data. In Vitro. 32:1996;299-304.
26. Chatterjee C., Correll M.J., Weathers P.J., Wyslouzil B.E., Walcerz D.B. Simplified acoustic window mist bioreactor. Biotechnol. Tech. 11:1997;155-158.
27. Seung H.W., Jong M.P. Root culture using a mist culture system and estimation of scale-up feasibility. J. Chem. Tech. Biotechnol. 66:1996;355-362.
28. Murashige T., Skoog F. A revised medium for rapid growth and bioassays with tobacco tissue cultures. Physiol. Plant. 15:1962;473-497.
29. Shen X.K., Yan K.D., Luo Z.Y. Determination of artemisinin content by ultraviolet meter. Chin. Pharm. Anal. 3:1983;24-26.
30. Dubois M., Gilles K.A., Hamilton J.K., Revers P.A., Smith F. Colorimetric methods for the determination of sugar and related substances. Anal. Chem. 28:1956;350-357.
31. Chen P.S., Toribara T.Y., Warner H. Microdetermination of phosphorus. Anal. Chem. 28:1956;1756-1759.