HIV type 1 Tat protein inhibits interleukin 12 production by human peripheral blood mononuclear cells

AIDS Research and Human Retroviruses

Volumn 14, Issue 10, 1998, Pages 845-849

  Ito, Masahiko ^a   Ishida, Takaomi ^a   He, Limin ^a   Tanabe, Fuminori ^a   Rongge, Yang ^a   Miyakawa, Yozo ^a   Terunuma, Hiroshi ^a  

^a UNIVERSITY OF YAMANASHI   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 6; TRANSACTIVATOR PROTEIN; TUMOR NECROSIS FACTOR ALPHA; VIRUS PROTEIN;

ARTICLE; CYTOTOXIC T LYMPHOCYTE; HELPER CELL; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS; IMMUNOADSORPTION; IMMUNOREGULATION; MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN SYNTHESIS INHIBITION; VIRUS EXPRESSION; VIRUS INFECTIVITY;

EID: 0032504018     PISSN: 08892229     EISSN: None     Source Type: Journal    
DOI: 10.1089/aid.1998.14.845     Document Type: Article

References (28)

1. Trinchieri G: Interleukin-12: A cytokine produced by antigen-presenting cells with immunoregulatory functions in the generation of T-helper cell type 1 and cytotoxic lymphocytes. Blood 1994;84: 4008-4027.
2. Chehimi J, Starr SE, Frank I, D'Andrea A, Ma X, MacGregor RR, Sennelier J, and Trinchieri G: Impaired interleukin 12 production in human immunodeficiency virus-infected patients. J Exp Med 1994;179:1361-1366.
3. Denis M and Ghadirian E: Dysregulation of interleukin 8, interleukin 10, and interleukin 12 released by alveolar macrophages from HIV type 1-infected subjects. AIDS Res Hum Retroviruses 1994;10:1619-1627.
4. Sodroski J, Rosen C, Wong-Staal F, Salahuddin SZ, Popovic M, Arya S, Gallo RC, and Haseltine WA: Trans-acting transcriptional regulation of human T-cell leukemia virus type III long terminal repeat. Science 1985;227:171-173.
5. Westendorp MO, Shatrov VA, Schulze-Osthoff K, Frank R, Kraft M, Los M, Krammer PH, Droge W, and Lehmann V: HIV-1 Tat potentiates TNF-induced NF-κB activation and cytotoxicity by altering the cellular redox state. EMBO J 1995;14:546-554.
6. Scala G, Ruocco MR, Ambrosino C, Mallardo M, Giordano V, Baldassarre F, Dragonetti E, Quinto I, and Venuta I: The expression of the interleukin 6 gene is induced by the human immunodeficiency virus 1 Tat protein. J Exp Med 1994;179:961-971.
7. Howcroft TK, Strebel K, Martin MA, and Singer DS: Repression of MHC class I gene promoter activity by two-exon Tat of HIV. Science 1993;260:1320-1322.
8. Purvis SF, Georges DL, Williams TM, and Lederman MM: Suppression of interleukin-2 and interleukin-2 receptor expression in Jurkat cell stably expressing the human immunodeficiency virus Tat protein. Cell Immunol 1992;144:32-42.
9. Pocsik E, Higuchi M, and Aggarwal EB: Down-modulation of cell surface expression of P80 form of the tumor necrosis factor receptor by human immunodeficiency virus-1 tat gene. Lymphokine Cytokine Res 1992;11:317-325.
10. Viscidi RP, Mayur K, Lederman HM, Frankel AD: Inhibition of antigen-induced lymphocyte proliferation by Tat protein from HIV-1. Science 1989;246:1606-1608.
11. Fauci AS: The human immunodeficiency virus: Infectivity and mechanisms of pathogenesis. Science 1988;239:617-622.
12. Piatak M, Saag MS Jr, Yang LC, Clark SJ, Kappes JC, Luk K-CB, Hahn BH, Shaw GM, and Lifson JD: High levels of HIV-1 in plasma during all stages of infection determined by competitive PCR. Science 1993;259:1749-1754.
13. Frankel AD and Pabo CO: Cellular uptake of the Tat protein from human immunodeficiency virus. Cell 1988;55:1189-1193.
14. Magnuson DS, Knudsen BE, Geiger RM, Brownstone RM, and Nath A: Human immunodeficiency virus type 1 Tat activates non-N-methyl-D-aspartamate excitatory amino acid receptors and causes neurotoxicity. Ann Neurol 1995;37:373-380.
15. de Waal Malefyt R, Abrams J, Bennett B, Figdor CG, and de Vries DE: Interleukin 10 (IL-10) inhibits cytokine synthesis by human monocytes: An autoregulatory role of IL-10 produced by monocytes. J Exp Med 1991;174:1209-1220.
16. Wolf SF, Temple PA, Kobayashi M, Young D, Dicig M, Lowe L, Dzialo R, Fitz L, Ferenz C, Hewick RM, Kelleher K, Herrmann SH, Clark C, Azzoni L, Chan SH, Trinchieri G, and Perussia B: Cloning of cDNA for natural killer cell stimulatory factor, a heterodimeric cytokine with multiple biologic effects on T and natural killer cells. J Immunol 1991;146:3074-3081.
17. D'Andrea A, Aste-Amezaga M, Valiante NM, Ma X, Kubin M, and Trinchieri G: Interleukin 10 (IL-10) inhibits human lymphocyte interferon-γ production by suppressing natural killer cell stimulatory factor/IL-12 synthesis in accessory cells. J Exp Med 1993;178:1041-1048.
18. 125I-labeled protein A as a tracer in immunoassay: Suitability of goat and sheep antibodies. J Immunol Methods 1980;34:93-106.
19. Li CJ, Friedman DJ, Wang C, Metelev V, and Pardee AB: Induction of apoptosis in uninfected lymphocytes by HIV-1 Tat protein. Science 1995;268:429-431.
20. D'Andrea A, Rengaraju M, Valiante NM, Chehimi J, Chan M, Kobayashi M, Young D, Nickbarg E, Chizzonite R, Wolf SF, and Trinchieri G: Production of natural killer cell stimulatory factor (interleukin 12) by peripheral blood mononuclear cells. J Exp Med 1992;176:1387-1398.
21. Ameglio F, Capobianchi MR, Castilletti C, Cordiali Fei P, Fais S, Trento E, Dianzani F: Recombinant gp120 induces IL-10 in resting peripheral blood mononuclear cells; correlation with the induction of other cytokines. Clin Exp Immunol 1994;95:455-458.
22. Hayes MP, Wang J, and Norcross MA: Regulation of interleukin-12 expression in human monocytes: Selective priming by interferon-γ of lipopolysaccharide-inducible p35 and p40 genes. Blood 1995;86:646-650.
23. D'Andrea A, Ma X, Aste-Amezaga M, Paganin C, and Trinchieri G: Stimulatory and inhibitory effects of interleukin (IL)-4 and IL-13 on the production of cytokines by human peripheral blood mononuclear cells: Priming for IL-12 and tumor necrosis factor α production. J Exp Med 1995;181:537-546.
24. 2 is a potent inhibitor of human interleukin 12 production. J Exp Med 1995;181:775-779.
25. Baron P, Constantin G, D'Andrea A, Ponzin D, Scarpini E, Trinchieri G, Rossi F, and Cassatella MA: Production of tumor necrosis factor and other proinflammatory cytokines by human mononuclear phagocytes stimulated with myelin P2 protein. Proc Natl Acad Sci USA 1993;90:4414-4418.
26. Ensoli B, Gendelman R, Markham P, Fiorelli V, Colombini S, Raffeld M, Cafaro A, Chang H-K, Brady JN, and Gallo RC: Synergy between basic fibroblast growth factor and HIV-1 Tat protein in induction of Kaposi's sarcoma. Nature (London) 1994;371: 674-680.
27. Karp CL, Wysocka M, Wahl LM, Ahearn JM, Cuomo PJ, Sherry B, Trinchieri G, and Griffin DE: Mechanism of suppression of cell-mediated immunity by measles virus. Science 1996;273:228-231.
28. Westendorp MO, Frank R, Ochsenbauer C, Stricher K, Dhein J, Walczak H, Debatin K-H, and Krammer PH: Sensitization of T cells to CD95-mediated apoptosis by HIV-1 Tat and gp120. Nature (London) 1995;375:497-500.