The clinical pharmacology of anticholinergic antiparkisonian drugs: A review with emphasis on acute toxicity;Antikolinerge antiparkinsonmedikamenters kliniske farmakologi: En oversikt med vekt pa akutt toksisitet

Tidsskrift for den Norske Laegeforening

Volumn 118, Issue 1, 1998, Pages 53-55

  Gjerden, Pål ^a   Slørdal, Lars ^b  

^a Telemark Sentralsjukehus   (Norway)

^b Statens Rettstoksikologiske I   (Norway)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIPARKINSON AGENT; BENZATROPINE; BIPERIDEN; CHOLINERGIC RECEPTOR BLOCKING AGENT; NEUROLEPTIC AGENT; ORPHENADRINE;

CLINICAL PHARMACOLOGY; DEATH; DRUG OVERDOSE; EXTRAPYRAMIDAL SYMPTOM; HUMAN; NORWAY; PHARMACOKINETICS; REVIEW;

ANTIPARKINSON AGENTS; BENZTROPINE; BIPERIDEN; HUMANS; MUSCLE RELAXANTS, CENTRAL; ORPHENADRINE; OVERDOSE; RISK FACTORS;

EID: 0032501680     PISSN: 00292001     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (26)

1. Hunskaar S, Donnell D. Clinical and pharmacological review of the efficacy of orphenadrine and its combination with paracetamol in painful conditions. J Int Med Res 1991; 19: 71-87.
2. Dollery C, red. Therapeutic drugs. Bd. 1. London: Churchill Livingstone, 1991.
3. Ellenhorn MJ, Barceloux DG. Medical toxicology. Diagnosis and treatment of human poisoning. London: Elsevier, 1988.
4. Labout JJM, Thijssen CT, Keijser GGJ, Hespe W. Difference between single and multiple dose pharmacokinetics of orphenadrine hydrochloride in man. Eur J Clin Pharmacol 1982; 21: 343-50.
5. Cresteil A, Monsarrat B, Alvinerie P, Treluyer JM, Vieira I, Wright M. Taxol metabolism by human liver microsomes: identification of cytochrome P450 isoenzymes involved in its biotransformation. Cancer Res 1994; 54: 386-92.
6. Chang TK, Weber GF, Crespi CL, Waxman DJ. Differential activation of cyclophosphamide and iphosphamide by cytochrome P-450 2B and 3A in human liver microsomes. Cancer Res 1993; 53: 5629-37.
7. Hartvig P. Rusgivende misbruk av antiparkinsonmidler. Tidsskr Nor Lægeforen 1973; 93: 957.
8. Clarke B, Mair J, Rudolf M. Acute poisoning with orphenadrine. Lancet 1985; 1: 1386.
9. Bosche J, Mallach HJ. Über anatomische und chemisch toxikologische Befunde bei einer todlichen Vergiftung durch Orphenadrin. Arch Toxikol 1969; 25: 76-82.
10. Deceuninck F, Silverman RM, Veltman JGJ. Een patiente met cen psychose na intoxicatie met orfenadrin. Ned T Geneesk 1973; 117: 25-7.
11. Bozza-Marubini M, Frigerio A, Ghezzi R, Parelli L, Restelli L, Selenati A. Two cases of severe orphenadrine poisoning with atypical features. Acta Pharmacol Toxicol 1977; 41: 137-52.
12. Millar WM. Deaths after overdoses of orphenadrine. Lancet 1977; 2: 566.
13. Sangster B, Van Heijst ANP, Zimmerman ANE. Vergifting door orfenadrine. Ned T Geneesk 1978; 122: 988-92.
14. Robinson AE, Holder AT, McDowall RD, Powell R, Sattar H. Forensic toxicology of some orphenadrine-related deaths. Forensic Sci 1977; 9: 53-62.
15. Wilkinson LF, Thomson BM, Pannell LK. A report on the analysis of orphenadrine in post mortem specimens. J Anal Toxicol 1983; 7: 72-5.
16. Blomquist M, Bonnichsen R, Schubert B. Lethal orphenadrine intoxications. A report of five cases. Z Rechtsmedizin 1971; 68: 111.
17. Gjerden P, Engelstad KS, Pettersen G, Slørdal L. Dødsfall forårsaket av antikolinerge antiparkinsonmedikamenter. Analysefunn i et nasjonalt 11-årsmateriale. Tidsskr Nor Lægeforen; 1998; 118: 0000-00.
18. Wineck CL. Tabulation of therapeutic, toxic and lethal concentrations of drugs and chemicals in blood. Clin Chem 1976; 22: 832.
19. Schultz M, Schmoldt A. Zusammenstellung therapeutischer und toxischer plasmakonzentrationsbereiche von artzneistoffen. Anaesthesist 1994; 43: 835-44.
20. Lindboe CF, Svenes KB, Slørdal L. Sudden, unexpected death in subjects with undiagnosed gliomas. Am J Forensic Med Path; 1997; 18: 271-5.
21. Romano G, DiBono G. A fatality involving clothiapine and clomipramine. J Forensic Sci 1993; 39: 877-82.
22. Hewer W, Biedert S. Delirantes syndrom bei biperiden-intoxikation. Fortschr Neurol Psychiat 1988; 56: 133-6.
23. Wade LC, Ellenor GL. Combination of mesoridazine and benztropin mesylate induced paralytic ileus. Two case reports. Drug Intell Clin Pharm 1980; 14: 17-22.
24. Sarnquist F, Larson CP. Drug-induced heat stroke. Anesthesiology 1973; 3: 348-50.
25. Catterson ML, Martin RL. Anticholnergic toxity masquerading as neuroleptic malignant syndrome: a case report and review. Ann Clin Psychiatry 1994; 4: 267-9.
26. del Villar G, Liddy M. Two deaths involving bcnztropine. Bull Int Ass Forens Toxicol 1976; 12: 11-2.