Characterization of the neuropeptide Y5 receptor in the human hypothalamus: A lack of correlation between Y5 mRNA levels and binding sites

Brain Research

Volumn 810, Issue 1-2, 1998, Pages 16-26

  Statnick, Michael A ^a   Schober, Douglas A ^a   Gackenheimer, Susan ^a   Johnson, Dwayne ^a   Beavers, Lisa ^a   Mayne, Nancy G ^a   Burnett, J Paul ^a   Gadski, Robert ^a   Gehlert, Donald R ^a  

^a ELI LILLY AND COMPANY   (United States)

Author keywords

Appetite regulation; Human hypothalamus; mRNA Analysis; Obesity; Radioligand binding; Y1 receptor; Y2 receptor; Y5 receptor

Indexed keywords

MESSENGER RNA; NEUROPEPTIDE Y RECEPTOR;

ANIMAL CELL; ARTICLE; BINDING SITE; CHO CELL; GENE EXPRESSION; HUMAN; HYPOTHALAMUS; MOLECULAR CLONING; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DETERMINATION; RECEPTOR AFFINITY; RECEPTOR BINDING; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA ANALYSIS;

ANIMALS; BINDING SITES; BLOTTING, NORTHERN; CHO CELLS; CLONING, MOLECULAR; CRICETINAE; GENE EXPRESSION REGULATION; HUMANS; HYPOTHALAMUS; MEMBRANES; RADIOLIGAND ASSAY; RATS; RECEPTORS, NEUROPEPTIDE Y; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER;

EID: 0032501221     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(98)00855-5     Document Type: Article

References (41)

1. Balasubramaniam A., Sheriff S., Johnson M.E., Prabhakaran M., Huang Y., Fischer J.E., Chance W.T. [D-Trp32]Neuropeptide Y: a competitive antagonist of NPY in rat hypothalamus. J. Med. Chem. 37:1994;811-815.
2. Bard J.A., Walker M.W., Branchek T.A., Weinshank R.L. Cloning and functional expression of a human Y4 subtype receptor for pancreatic polypeptide, neuropeptide Y and peptide YY. J. Biol. Chem. 270:1995;26762-26765.
3. Becker-Andre M. Absolute levels of mRNA by polymerase chain reaction-aided transcript titration assay. Methods Enzymol. 218:1993;420-445.
4. DiMaggio D.A., Chronwall B.M., Buchman K., O'Donohue T.L. Pancreatic polypeptide immunoreactivity in rat brain is actually neuropeptide Y. Neuroscience. 15:1985;1149-1157.
5. Dumont Y., Fournier A., St-Pierre S., Quirion R. Comparative characterization and autoradiographic distribution of neuropeptide Y receptor subtypes in the rat brain. J. Neurosci. 13:1993;73-86.
6. 1 receptor agonist. Proc. Natl. Acad. Sci. U.S.A. 87:1990;182-186.
7. Gehlert D.R., Beavers L., Johnson D., Gackenheimer S.L., Schober D.A., Gadski R.A. Expression cloning of a human brain neuropeptide Y Y2 receptor. Mol. Pharmacol. 49:1996;224-228.
8. 125I ]-peptide YY binding sites in the human pituitary Peptides. 15:1994;651-656.
9. 125I -labelled peptide YY binding sites in the rat brain Neurochem. Int. 21:1992;45-67.
10. Gehlert D.R., Schober D.A., Beavers L., Gadski R., Hoffmann J.A., Smiley D.L., Chance R.E., Lundell I., Larhammar D. Characterization of the peptide binding requirements for the cloned human pancreatic polypeptide-preferring receptor. Mol. Pharmacol. 50:1996;112-118.
11. Gerald C., Walker M.W., Criscone L., Gustafson E.L., Batzl-Hartmann C., Smith K., Vaysse P., Durkin M.M., Laz T.M., Linemeyer D.L., Schaffhauser A.O., Whitebread S., Hofbauer K.G., Taber R.I., Branchek T.A., Weinshank R.L. A receptor subtype involved in neuropeptide-Y-induced food intake. Nature. 382:1996;168-171.
12. Gerald C., Walker M.W., Vaysse P.J.-J., He C., Branchek T.A., Weinshank R.L. Expression cloning and pharmacological characterization of a human hippocampal neuropeptide Y/peptide YY Y2 receptor subtype. J. Biol. Chem. 270:1995;26758-26761.
13. Gustafson E.L., Smith K.E., Durkin M.M., Walker M.W., Gerald C., Weinshank R., Branchek T.A. Distribution of the neuropeptide Y Y2 receptor mRNA in rat central nervous system. Mol. Brain Res. 46:1997;223-235.
14. Heilig M., Widerlov E. Neurobiology and clinical aspects of neuropeptide Y. Crit. Rev. Neurobiol. 9:1995;115-136.
15. Herzog H., Hort Y.J., Ball H.J., Hayes G., Shine J., Selbie L.A. Cloned human neuropeptide Y receptor couples to two different second messenger systems. Proc. Natl. Acad. Sci. U.S.A. 89:1992;5794-5798.
16. Hu Y., Bloomquist B.T., Cornfield L.J., DeCarr L.B., Flores-Riveros J.R., Friedman L., Jiang P., Lewis-Higgins L., Sadlowski Y., Schaefer J., Velazquez N., McCaleb M.L. Identification of a novel hypothalamic neuropeptide Y receptor associated with feeding behavior. J. Biol. Chem. 271:1996;26315-26319.
17. Jacques D., Dumont Y., Fournier A., Quirion R. Characterization of neuropeptide Y receptor subtypes in the normal human brain, including the hypothalamus. Neuroscience. 79:1997;129-148.
18. Jolicoeur F.B., Michaud J.N., Menard D., Fournier A. In vivo structure activity study supports the existence of heterogeneous neuropeptide Y receptors. Brain Res. Bull. 26:1991;309-311.
19. Kalra S.P., Dube M.G., Fournier A., Kalra P.S. Structure-function analysis of stimulation of food intake by neuropeptide Y: effects of receptor agonists. Physiol. Behav. 50:1991;5-9.
20. Kanatani A., Ishihara A., Asahi S., Tanaka T., Ozaki S., Ihara M. Potent neuropeptide Y Y1 receptor antagonist 1229U91: blockade of neuropeptide Y-induced and physiological food intake. Endocrinology. 137:1996;3177-3182.
21. Larhammar D., Blomquist A.G., Yee F., Jazin E., Yoo H., Wahlestedt C. Cloning and functional expression of a human neuropeptide Y/peptide YY receptor of the Y1 subtype. J. Biol. Chem. 267:1992;10935-10938.
22. Larsen P.J., Sheikh S.P., Jakobsen C.R., Schwartz T.W., Mikkelsen J.D. Regional distribution of putative NPY Y1 receptors and neurons expressing Y1 mRNA in forebrain areas of the rat central nervous system. Eur. J. Neurosci. 5:1993;1622-1637.
23. Leibowitz S.F. Hypothalamic neurochemical systems mediate drug effects on food intake. Clin. Neuropharmacol. 15:1992;701A-702A.
24. Lundell I., Blomqvist A.G., Berglund M., Schober D.A., Johnson D., Statnick M.A., Gadski R., Gehlert D.R., Larhammar D. Cloning of a human receptor of the NPY receptor family with high affinity for pancreatic polypeptide and peptide YY. J. Biol. Chem. 270:1995;29123-29128.
25. O'Shea D., Morgan D.G.A., Meeran K., Edwards C.M.B., Turton M.D., Choi S.J., Heath M.M., Gunn I., Taylor G.M., Howard J.K., Bloom C.I., Small C.J., Haddo O., Ma J.J., Callinan W., Smith D.M., Ghatei M.A., Bloom S.R. Neuropeptide Y induced feeding in the rat is mediated by a novel receptor. Endocrinology. 138:1997;196-202.
26. Roche C., Boutin P., Dina C., Gyapay G., Basdevant A., Hager J., Guy-Grand B., Clement K., Froguel P. Genetic studies of neuropeptide Y and neuropeptide Y receptors Y1 and Y5 regions in morbid obesity. Diabetologia. 40:1997;671-675.
27. Schaffhauser A.O., Stricker-Krongrad A., Brunner L., Cumin F., Gerald C., Whitebread S., Criscione L., Hofbauer K.G. Inhibition of food intake by neuropeptide Y Y5 receptor antisense oligonucleotides. Diabetes. 46:1997;1792-1798.
28. Schober D.A., Van Abbema A.M., Smiley D.L., Bruns R.F., Gehlert D.R. The neuropeptide Y Y1 antagonist, 1229U91, a potent agonist for the human pancreatic polypeptide-preferring (NPY Y4) receptor. Peptides. 19:1998;537-542.
29. Schwartz T.W., Sheikh S.P., O'Hare M.M.T. Receptors on phaeochromocytoma cells for two members of the PP-fold family - NPY and PP. FEBS Lett. 225:1987;209-214.
30. 2 receptors for neuropeptide Y. FEBS Lett. 245:1989;209-214.
31. Small C.J., Morgan D.G.A., Meeran K., Heath M.M., Gunn I., Edwards C.M.B., Gardiner J., Taylor G.M., Hurley J.D., Rossi M., Goldstone A.P., O'Shea D., Smith D.M., Ghatei M.A., Bloom S.R. Peptide analogue studies of the hypothalamic neuropeptide Y receptor mediating pituitary adrenocorticotrophic hormone release. Proc. Natl. Acad. Sci. U.S.A. 94:1997;11686-11691.
32. Stanley B.G., Magdalin W., Seirafi A., Nguyen M.M., Leibowitz S.F. Evidence for neuropeptide Y mediation of eating produced by food deprivation and for a variant of the Y1 receptor mediating this peptide's effect. Peptides. 13:1992;581-587.
33. Statnick M.A. Identification of multiple neuropeptide Y receptor subtypes in the human frontal cortex. Eur. J. Pharmacol. 332:1997;299-305.
34. Statnick M.A., Schober D.A., Mayne N.G., Burnett J.P., Gehlert D.R. Analysis of NPY receptor subtypes in the human frontal cortex reveals abundant Y1 mRNA and binding sites. Peptides. 18:1997;137-143.
35. Tatemoto K., Carlquist M., Mutt V. Neuropeptide Y - a novel brain peptide with structural similarities to peptide YY and pancreatic polypeptide. Nature. 296:1982;659-660.
36. Wahlestedt C., Grundemar L., Håkanson R., Heilig M., Shen G.H., Zukowska-Grojec Z., Reis D.J. Neuropeptide Y receptor subtypes, Y1 and Y2. Ann. New York Acad. Sci. 611:1990;7-26.
37. Wahlestedt C., Reis D.J. Neuropeptide Y-related peptides and their receptors are the receptors potential therapeutic drug targets? Annu. Rev. Pharmacol. Toxicol. 32:1993;309-352.
38. Wahlestedt C., Yanaihara N., Håkanson R. Evidence for different pre- and post-junctional receptors for neuropeptide Y and related peptides. Regul. Peptides. 13:1986;307-318.
39. Wettstein J.G., Earley B., Juniens J.L. Central nervous system pharmacology of neuropeptide Y. Pharmacol. Ther. 65:1995;397-414.
40. Widdowson P.S. Regionally-selective down-regulation of NPY receptor subtypes in the obese Zucker rat. Relationship to the Y5 'feeding' receptor. Brain Res. 758:1997;17-25.
41. Williams G., Cardoso H.M., Lee Y.C., Ball J.M., Ghatei M.A., Stock M.J., Bloom S.R. Hypothalamic regulatory peptides in obese and lean Zucker rats. Clin. Sci. 80:1991;419-426.