Mechanisms of photosensitization by phototoxic drugs

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis

Volumn 422, Issue 1, 1998, Pages 165-173

  Moore, Douglas E ^a  

^a UNIVERSITY OF SYDNEY   (Australia)

Author keywords

Azathioprine; Diclofenac; Naproxen; Photochemical mechanism; Photosensitizers; Phototoxic drug; Sulfamethoxazole

Indexed keywords

AZATHIOPRINE; DICLOFENAC; NAPROXEN; NONSTEROID ANTIINFLAMMATORY AGENT; SULFAMETHOXAZOLE;

CONFERENCE PAPER; HUMAN; PHOTODEGRADATION; PHOTOSENSITIZATION; PHOTOTOXICITY; PRIORITY JOURNAL; SUNLIGHT; ULTRAVIOLET RADIATION;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; HEMOLYSIS; HUMANS; PHOTOSENSITIVITY DISORDERS; PHOTOSENSITIZING AGENTS; SUNLIGHT; ULTRAVIOLET RAYS;

EID: 0032501126     PISSN: 00275107     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0027-5107(98)00189-4     Document Type: Conference Paper

References (12)

1. [1] D.E. Moore, Photophysical and photochemical aspects of drug stability, in: H.H. Tonnesen (Ed.), Photostability of Drugs and Drug Formulation, Taylor and Francis, London, 1996, pp. 9-38.
2. [2] D.E. Moore, P.P. Chappuis, A comparative study of photochemical sensitization by the non-steroidal anti-inflammatory drugs, naproxen, benoxaprofen and indomethacin, Photochem. Photobiol. 47 (1988) 173-180.
3. [3] J.H. Epstein, Photomedicine, in: K.C. Smith (Ed.), The Science of Photobiology, Plenum, New York, 1989, pp. 155-192.
4. [4] S.A. Schoonderwoerd, G.M.J. Bejiersbergen van Henegouwen, S. van Belkum, In vivo photodegradation of chlorpromazine, Photochem. Photobiol. 50 (1989) 659-664.
5. [5] D.E. Moore, S. Roberts-Thomson, Z. Dong, C.C. Duke, Photochemical studies on the anti-inflammatory drug diclofenac, Photochem. Photobiol. 52 (1990) 685-690.
6. [6] V.J. Hemmens, D.E. Moore, Photochemical sensitization by azathioprine and its metabolites: I. 6-Mercaptopurine, Photochem. Photobiol. 43 (1986) 247-255.
7. [7] D.E. Moore, R.H. Sik, P. Bilski, C.F. Chignell, K.J. Reszka, Photochemical sensitization by azathioprine and its metabolites: III. A direct EPR and spin trapping study of light induced free radicals from 6-mercaptopurine and its oxidation products, Photochem. Photobiol. 60 (1994) 574-581.
8. [8] D.E. Moore, W. Zhou, Photodegradation of sulfamethoxazole: a chemical system capable of monitoring seasonal changes in UVB intensity, Photochem. Photobiol. 59 (1994) 497-502.
9. [9] W. Zhou, D.E. Moore, Photochemical decomposition of sulfamethoxazole, Int. J. Pharm. 110 (1994) 55-63.
10. [10] W. Zhou, D.E. Moore, Photosensitizing activity of the anti-bacterial drugs sulfamethoxazole and trimethoprim, J. Photochem. Photobiol. 39 (1997) 63-72.
11. [11] M.A. Miranda, J.V. Castell, M.J. Gómez-Lechón, L.A. Martinez, In vitro photoperoxidation as an indicator of the potential phototoxicity of non-steroidal anti-inflammatory 2-arylpropionic acids, Toxicol. in Vitro 7 (1993) 523-526.
12. [12] G.E. Kelly, W.D. Meikle, D.E. Moore, Promotion of UV-induced skin carcinogenesis in hairless mice: role of photochemical sensitization, Photochem. Photobiol. 49 (1989) 59-65.