Cholinergic agonists increase intracellular Ca2+ in cultured human microglia

Neuroscience Letters

Volumn 255, Issue 1, 1998, Pages 33-36

  Zhang, Lili ^a   McLarnon, James G ^a   Goghari, Vikram ^a   Lee, Yong Beom ^a   Kim, Seung U ^a   Krieger, Charles ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

Acetylcholine; Carbachol; Fura 2; Human; Intracellular free calcium; Microglia

Indexed keywords

ACETYLCHOLINE; CARBACHOL; CHOLINERGIC RECEPTOR STIMULATING AGENT; FURA 2;

ARTICLE; CALCIUM CELL LEVEL; CALCIUM TRANSPORT; CELL CULTURE; CENTRAL NERVOUS SYSTEM; DESENSITIZATION; HUMAN; HUMAN CELL; MICROGLIA; NEUROTRANSMITTER RELEASE; PHAGOCYTOSIS; PRIORITY JOURNAL; SECOND MESSENGER; SIGNAL TRANSDUCTION; STEM CELL; SYNAPTIC TRANSMISSION;

ATROPINE; CALCIUM; CARBACHOL; CELLS, CULTURED; CHOLINERGIC AGONISTS; DRUG ADMINISTRATION SCHEDULE; DRUG COMBINATIONS; FETUS; HUMANS; INTRACELLULAR MEMBRANES; MICROGLIA; MUSCARINIC ANTAGONISTS; OSMOLAR CONCENTRATION;

EID: 0032500781     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3940(98)00706-X     Document Type: Article

References (12)

1. Buxbaum J.D., Oishi M., Chen H.I., Pinkas-Kramarski R., Jaffe E.A., Gandy S.E., Greengard P. Cholinergic agonists and interleukin 1 regulate processing and secretion of the Alzheimer beta/A4 amyloid protein precursor. Proc. Natl. Acad. Sci. USA. 89:1992;10075-10078.
2. Hasham M.I., Naumann D., Kim S.U., Cashman N.A., Quamme G.A., Krieger C. Intracellular calcium concentrations during metabolic inhibition in the motoneuron cell line NSC-19. Can. J. Physiol. Pharmacol. 72:1994;728-737.
3. Nathanson N.M. Molecular properties of the muscarinic acetylcholine receptor. Annu. Rev. Neurosci. 10:1987;195-236.
4. Nitsch R.M., Slack B.E., Wurtman R.J., Growdon J.H. Release of Alzheimer amyloid precursor derivatives stimulated by activation of muscarinic acetylcholine receptors. Science. 258:1992;304-307.
5. Pow D.V., Perry V.H., Morris J.F., Gordon S. Microglia in the neurohypophysis associated with endocytose terminal portions of neurosecretary neurons. Neuroscience. 33:1989;567-578.
6. Satoh J.-I., Kim S.U. Differential expression of heat shock protein HSP27 in human neurons and glial cells in culture. J. Neurosci. Res. 41:1995;805-818.
7. Selkoe D.J. The molecular pathology of Alzheimer's disease. Neuron. 6:1991;487-498.
8. Streit W.J., Graeber M.B., Kreutzberg G.W. Functional plasticity of microglia: a review. Glia. 1:1988;301-307.
9. Walker D.G., Kim S.U., McGeer P.L. Complement and cytokine gene expression in cultured microglia derived from postmortem human brains. J. Neurosci. Res. 40:1995;478-493.
10. Wessler I., Reinheimer T., Klapproth H., Schneider F.J., Racke K., Hammer R. Mammalian glial cells in culture synthesize acetylcholine. Naunyn-Schmiedeberg's Arch. Pharmacol. 356:1997;694-697.
11. Whittemore E.R., Korotzer A.R., Etebari A., Cotman C.W. Carbachol increases intracellular free calcium in cultured rat microglia. Brain Res. 621:1993;59-64.
12. 2+ and membrane currents in cultured human microglia. Neurosci. Lett. 218:1996;37-40.