Homocysteine plasma levels in patients with ischemic stroke;Concentraciones plasmáticas de homocisteína en pacientes con infarto cerebral isquémico

Medicina Clinica

Volumn 110, Issue 16, 1998, Pages 605-608

  Vila, Nícolás ^a   Deulofeu, Ramón ^a   Chamorro, Ángel ^a   Piera, Carlos ^a  

^a HOSPITAL CLÍNIC   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

CREATININE; CYANOCOBALAMIN; FOLIC ACID; HOMOCYSTEINE;

ARTICLE; BLOOD; BRAIN INFARCTION; BRAIN ISCHEMIA; COMPARATIVE STUDY; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; MALE; MIDDLE AGED; REGRESSION ANALYSIS; RISK FACTOR;

BRAIN ISCHEMIA; CEREBRAL INFARCTION; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CREATININE; FEMALE; FOLIC ACID; HOMOCYSTEINE; HUMANS; MALE; MIDDLE AGED; REGRESSION ANALYSIS; RISK FACTORS; VITAMIN B 12;

EID: 0032499322     PISSN: 00257753     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (33)

1. Ue and PM. Refsum H. Plasma homocysteine, a risk factor for vascular disease: plasma levels in health. disease and drug therapy. J Lab Clin Med 1989: 114: 473-501.
2. Rees MM, Rodgers GM. Homocysteinemia: association of a metabolic disorder with vascular disease and thrombosis. Thromb Res 1993: 71: 337-359.
3. Wilcken DEL, Wilcken B. The pathogenesis of coronary artery disease: a possible role for methionine metabolism J Clin Invest 1976: 57: 1.079-1.082.
4. Perry IJ, Refsum H, Morris RW, Ebrahim SB, Ueland PM, Shaper AG. Prospective study of serum total homocysteine concentration and risk of stroke in middle-age British men. Lancet 1995: 346: 1.395-1.398.
5. Verhoef P, Hennekens CH, Malinow R, Kok FJ, Willet WC, Stampfer MJ. A prospective study of plasma homocysteine and risk of ischemic stroke. Stroke 1994: 25: 1.924-1.930.
6. Selhub J, Jacques PF, Bostom AG, D'Agostino RB, Wilson PW, Belanger AJ et al. Associaton between plasma homocysteine concentrations and extracraneal carotid-artery stenosis. N Engl J Med 1995: 332: 286-291.
7. Stampfer MJ, Malinow R, Willet WC, Rosner B, Eberlein K, Hennekens CH. A prospective study of plasma homocysteine and risk of myocardial infarction in US physicians. JAMA 1992: 268: 877-881.
8. Nygard O, Vollset SE, Refsum H, Stensvold I, Tverdal A, Nodrehaug JE et al. Total plasma homocysteine and cardiovascular risk pofile. The Horsaland Homocysteine Study. JAMA 1995: 274: 1.526-1.533.
9. Heijer M, Koster T, Blom HJ, Bos GMJ, Briet E, Reitsma PH et al. Hiperhomocysteinemia as a risk factor for deep-vein thrombosis. N Engl J Med 1996; 334: 759-762.
10. Fermo I, D'Angelo SV, Paroni R, Mazzola G, Calori G, D'Angelo A. Prevalence of moderate hyperhomocysteinemia in patients with early-onset venous and arterial occlusive disease. Ann Intern Med 1995; 123: 747-753.
11. Mereau-Richard C, Mullei JP, Faivre E, Ardouin P, Rousseaux J. Total plasma homocysteine determination in subjects with premature cerebral vascular disease. Clin Chemother 1991; 37: 126.
12. Brattström L, Lindgren A, Israelsson B, Malinow MR, Norrving B, Upson B et al. Hyperhomocysteinemia in stroke: prevalence, causes and relationships to type of stroke and stroke risk factors. Eur J Clin Invest 1992; 22: 214-221.
13. Malinow MR. Homocysteine and arterial occlusive disease. J Intern Med 1994; 236: 603-617
14. Kang SS, Wong PWK, Susmano A, Sora J, Norusis M, Ruggie N. Thermolabile methylenete-trahydrofolate reductase: an inherited risk factor for coronary artery disease. Am J Hum Genet 1991; 48: 536-545.
15. Selhub J, Jacques PF, Wilson PWF, Rush D, Rosenberg IH. Vitamin status and intake as primary determinants of homocysteinemia in an elderly population JAMA 1993; 270: 2.693-2.698.
16. Brattström L, Lindgren A, Israelsson B, Andersson A, Hultberg B. Homocysteine and cysteine: determinants of plasma levels in middle-aged and elderly subjects. J Intern Med 1994; 236: 633-641.
17. Andersson A, Brattström L, Israelsson B, Isaksson A, Hamfelt A, Hultberg B. Plasma homocysteine before and after methionine loading with regard to age. gender and menupausal status. Eur J Clin Invest 1992; 2: 79-87.
18. Lindgren A, Brattström L, Norrving B, Hultberg B, Andersson A, Johansson BB. Plasma homocysteine in the acute and convalescent phases after stroke. Stroke 1995; 26 795-800.
19. Deulofeu R, Giralt M, Aibar C, Bauchet C, Varela-Moreiras G, Casals F et al. Determinación de homocisteina en plasma por cromatografía líquida de alta resolución. Aplicación al estudio de enfermos afectos de enfermedad vascular cereoral y periférica. Quim Clin 1996; 15: 77-84.
20. Dudman NPB, Wilcken DEL, Wang J, Lynch JF, Macey D, Lundberg P. Disordered methionine/homocysteine metabolism in premature vascular disease: its occurrence, cofactor therapy, and enzymology. Arterioscler Thromb 1993; 13: 1.253-1.260.
21. Araki A, Sako Y, Fukushima Y, Matsumoto M, Asada T, Kita T. Plasma sulfhydril-containing amino acids in patients with cerebral infarction and hypertensive subjects. Atherosclerosis 1989; 79: 139-146.
22. Coull BM, Malinow MR, Beamer N, Sexton G, Nordt F, De Garmo P. Elevated plasma homocysteine concentration as a possible independent risk factor for stroke Stroke 1990; 21: 572-576.
23. Brattström L, Israelsson B, Norrving B, Bergqvist D, Thörne J, Hultberg B et al. Impaired homocysteine metabolism in early-onset cerebral and peripheral occlusive arterial disease. Atherosclerosis 1990; 81: 51-60.
24. Evers S, Koch HG, Grotemeyer KH, Ullrich K, Deufel T, Harms E. Hyperhomocysteinemia in ischemic stroke is not due to mutations of the cystathionine-beta-synthase gene. Cerebrovasc Dis 1996; 6 (Supl 2): 19.
25. Beaumont V, Malinow MR, Sexton G, Wilson D, Lemort N, Upson B et al. Hyperhomocysteinemia. anti-estrogen antibodies and other risk factors for thrombosis in women on oral contraceptives. Ahterosclerosis 1992; 94: 147-152.
26. Boers GHJ, Smals AGH, Trijbels FJM, Fowler B, Bakkeren JAJM, Schoonderwaldt HC et al. Heterozygosity for homocystinuria in premature peripheral and cerebral occlusive disease. N Engl J Med 1985; 313: 709-715.
27. Clarke R, Daly L, Robinson K, Naughten E, Cahalane S, Fowler B et al. Hyperhomocysteinemia: an independent risk factor for vascular disease. N Engl J Med 1991; 324: 1.149-1.155.
28. Jacques PF, Bostom AG, Williams RR, Ellison RC, Eckfeldt JH, Rosenberg IH et al. Relation between folate status, a common mutation in methylenetetrahydrofolate reductase. and plasma homocysteine concentrations. Circulation 1996; 93: 7-9.
29. Tsai JC, Perrella MA, Yoshizumi M, Hsieh CM, Haber E, Schlegel R et al. Promotion of vascular smooth cell growth by homocysteine: a link to atherosclerosis. Proc Natl Acad Sci USA 1994; 91: 6.369-6.373.
30. Harpel PC, Zhang X, Borth W. Homocysteine and hemostasis: pathogenic mechanisms predisposing to thrombosis. J Nutr 1996; 126 (Supl): 1.285-1.289.
31. Stamler JS, Osborne JA, Jaraki O, Rabbani LE, Mullins M, Singel D et al. Adverse vascular effects of homocysteine are modulated by endothelium-derived relaxing factor and related oxides of nitrogen. J Clin Invest 1993; 91: 308-318.
32. Boushey CJ, Beresford SA, Omenn GS, Motulsky AG. A quantitative assessment of plasma homocysteine as a risk factor for vascular disease: probable benefits of increasing folic acid intakes. JAMA 1995; 274: 1.049-1.057.
33. Battström L. Vitamins as homocysteine-lowering agents. J Nutr 1996; 126 (Supl): 1.276-1.280.