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1. For recent thematic journal issues devoted to combinatorial chemistry, see: (a) Chem. Rev. 1997, 97, #2.
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(1997)
Chem. Rev.
, vol.97
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3
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For other recent general reviews, see (a) Balkenhohl, F.; von dem Bussche-Hünnefeld, C.; Lansky, A.; Zechel, C. Angew. Chem. Int. Ed. Engl. 1996, 35, 2288-2337.
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Angew. Chem. Int. Ed. Engl.
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Balkenhohl, F.1
Von Dem Bussche-Hünnefeld, C.2
Lansky, A.3
Zechel, C.4
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6
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0029930278
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2. For recent reviews on solid-phase organic synthesis, see: (a) Hermkens, P. H. H.; Ottenheijm, H. C. J.; Rees, D. C. Tetrahedron 1996, 52, 4527-4554.
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(1996)
Tetrahedron
, vol.52
, pp. 4527-4554
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Hermkens, P.H.H.1
Ottenheijm, H.C.J.2
Rees, D.C.3
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7
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(b) Hermkens, P. H. H.; Ottenheijm, H. C. J.; Rees, D. C. Tetrahedron 1997, 53, 5643-5678.
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Tetrahedron
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Hermkens, P.H.H.1
Ottenheijm, H.C.J.2
Rees, D.C.3
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9
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3. (a) McDonald, A. A.; DeWitt, S. H.; Hogan, E. M.; Ramage, R. Tetrahedron Lett. 1996, 37, 4815-4818.
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Tetrahedron Lett.
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McDonald, A.A.1
DeWitt, S.H.2
Hogan, E.M.3
Ramage, R.4
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10
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0030200397
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(b) Gordeev, M. F.; Patel, D. V.; Wu, J.; Gordon, E. M. Tetrahedron Lett. 1996, 37, 4643-4646.
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(1996)
Tetrahedron Lett.
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Gordeev, M.F.1
Patel, D.V.2
Wu, J.3
Gordon, E.M.4
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(f) Tietze, L. F.; Steinmetz, A.; Balkenhohl, F. Bioorg. Med. Chem. Lett. 1997, 7, 1303-1306.
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Bioorg. Med. Chem. Lett.
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Tietze, L.F.1
Steinmetz, A.2
Balkenhohl, F.3
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20
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0001246036
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6. We are not aware of any recent publications on solid-phase C-acylation. Earlier reports have described acylation of ester enolates: (a) Patchornik, A.; Kraus, M. A. J. Am. Chem. Soc. 1970, 92, 7587-7589.
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(1970)
J. Am. Chem. Soc.
, vol.92
, pp. 7587-7589
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Patchornik, A.1
Kraus, M.A.2
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21
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0016320981
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(b) Kraus, M. A.; Patchornik, A. J. Polym. Sci., Polym. Symp. 1974, 47, 11-18.
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(1974)
J. Polym. Sci., Polym. Symp.
, vol.47
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Kraus, M.A.1
Patchornik, A.2
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23
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0003592858
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Benjamin: New York
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7. For reviews on C-acylation of active methylene compounds, see: (a) House, H. O. Modern Synthetic Reactions (2nd ed.); Benjamin: New York, 1972; pp. 734-765 and 772-786.
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(1972)
Modern Synthetic Reactions (2nd Ed.)
, pp. 734-765
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House, H.O.1
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24
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0000010274
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Trost, B. M.; Fleming, I., Eds.; Pergamon: Oxford
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(b) Davies, B. R.; Garratt, P. J. In Comprehensive Organic Synthesis; Trost, B. M.; Fleming, I., Eds.; Pergamon: Oxford, 1991; Vol. 2, pp. 795-863.
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(1991)
Comprehensive Organic Synthesis
, vol.2
, pp. 795-863
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Davies, B.R.1
Garratt, P.J.2
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25
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11944265303
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(c) Benetti, S.; Romagnoli, R.; De Risi, C.; Spalluto, G.; Zanirato, V. Chem. Rev. 1995, 95, 1065-1114.
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Chem. Rev.
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Benetti, S.1
Romagnoli, R.2
De Risi, C.3
Spalluto, G.4
Zanirato, V.5
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27
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0001576379
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(b) Yamada, S.; Yokoyama, Y.; Shioiri, T. J. Org. Chem. 1974, 39, 3302-3303.
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J. Org. Chem.
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, pp. 3302-3303
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Yamada, S.1
Yokoyama, Y.2
Shioiri, T.3
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28
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0017168453
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(c) Shioiri, T.; Yokoyama, Y.; Kasai, Y.; Yamada, S. Tetrahedron 1976, 32, 2211-2217.
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(1976)
Tetrahedron
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Shioiri, T.1
Yokoyama, Y.2
Kasai, Y.3
Yamada, S.4
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30
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0019511115
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10. The nature of the acylating agent under these conditions is not fully understood, and may either be the acyl cyanide or the acyl phosphate: Hamada, Y.; Ando, K.; Shiori, T. Chem. Pharm. Bull. 1981, 29, 259-261.
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(1981)
Chem. Pharm. Bull.
, vol.29
, pp. 259-261
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Hamada, Y.1
Ando, K.2
Shiori, T.3
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31
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0010553766
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note
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2), concentrated, and chromatographed (silica, hexanes/ethyl acetate 75:25) to yield 12.5 mg of benzoylacetonitrile.
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32
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33748665505
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12. Kim, D. Y.; Kong, M. S.; Lee, K. J. Chem. Soc., Perkin, Trans. 1 1997, 1361-1363.
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(1997)
Chem. Soc., Perkin, Trans. 1
, pp. 1361-1363
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Kim, D.Y.1
Kong, M.S.2
Lee, K.J.3
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