Desensitization of β3-adrenergic receptor-stimulated adenylyl cyclase activity and lipolysis in rats

Life Sciences

Volumn 62, Issue 7, 1998, Pages 627-638

  Vicario, Pasquale P ^a   Candelore, Mari R ^a   Schaeffer, Marie Therese ^a   Kelly, Linda ^a   Thompson, G Marie ^a   Brady, Edward J ^a   Saperstein, Richard ^a   MacIntyre, D Euan ^a   Tota, Laurie M ^a   Cascieri, Margaret A ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

3 agonist; Adipocyte; Desensitization

Indexed keywords

4 [2 [[2 (3 CHLOROPHENYL) 2 HYDROXYETHYL]AMINO]PROPYL]PHENOXYACETIC ACID; 4 [2 [[2 (3 CHLOROPHENYL) 2 HYDROXYETHYL]AMINO]PROPYL]PHENOXYACETIC ACID METHYL ESTER; ADENYLATE CYCLASE; BETA 3 ADRENERGIC RECEPTOR; MESSENGER RNA; TRIACYLGLYCEROL LIPASE; UNCOUPLING PROTEIN; BETA ADRENERGIC RECEPTOR; BETA ADRENERGIC RECEPTOR STIMULATING AGENT; ETHANOLAMINE DERIVATIVE; GLYCEROL; PHENETHYLAMINE DERIVATIVE; PRODRUG;

ADIPOSE TISSUE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DESENSITIZATION; DOSE RESPONSE; ENZYME ACTIVITY; GLYCEROL BLOOD LEVEL; LIPOLYSIS; MALE; NONHUMAN; ORAL DRUG ADMINISTRATION; POLYMERASE CHAIN REACTION; RAT; ADIPOCYTE; ANIMAL; BLOOD; BROWN ADIPOSE TISSUE; DRUG EFFECT; ENZYMOLOGY; KINETICS; METABOLISM; SENSITIVITY AND SPECIFICITY; SPRAGUE DAWLEY RAT; ULTRASTRUCTURE;

ANIMALIA; RODENTIA;

ADENYLATE CYCLASE; ADIPOCYTES; ADIPOSE TISSUE; ADIPOSE TISSUE, BROWN; ADRENERGIC BETA-AGONISTS; ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; ETHANOLAMINES; GLYCEROL; KINETICS; LIPASE; LIPOLYSIS; MALE; PHENETHYLAMINES; PRODRUGS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, ADRENERGIC, BETA; RECEPTORS, ADRENERGIC, BETA-3; SENSITIVITY AND SPECIFICITY;

EID: 0032497968     PISSN: 00243205     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0024-3205(97)01158-2     Document Type: Article

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