An acid- and base-stable o-nitrobenzyl photolabile linker for solid phase organic synthesis

Tetrahedron Letters

Volumn 39, Issue 41, 1998, Pages 7451-7454

  Sternson, Scott M ^a   Schreiber, Stuart L ^a  

^a HARVARD UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; CHEMICAL REACTION; CHEMICAL STRUCTURE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

EID: 0032497708     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(98)01668-2     Document Type: Article

References (12)

1. 1. Borchardt, A.; Liberlas, S.D.; Biggar, S.R.; Crabtree, G.R.; Schreiber S.L. Chem. Biol. 1997, 4, 961.
2. 2. You, A.J.; Jackman, R.S.; Whitesides; G.M.; Schreiber, S.L.; Chem. Biol. 1997, 4, 969.
3. 3. Brown, B.B.; Wagner, D.S.; Geysen, H.M. Mol. Div. 1995, 1, 4.
4. 4. Rodebaugh, R.; Fraser-Reid, B.; Geysen, H.M. Tetrahedron Lett. 1997, 38, 7653.
5. 5. Holmes, C.P.; Jones, D.G. J. Org. Chem. 1995, 60, 2318.
6. 6. Kanazawa, A.M.; Denis. J-N.;Greene, A.E. J. Org. Chem. 1994, 59, 1238.
7. + 361.1376, found 361.1362.
8. -1. HATU= O-(7-azabenzotriazol-1-y1)-1,1,3,3-tetramethyluronium hexafluorophosphate
9. 2.
10. 3CN in water/0.1% TFA, constant 0.1% MeOH was used. Absorbance was measured at 254 nm.
11. 11. The isonicotinamide chromophore was not used in these studies due to the reactivity of the isonicotinic ring under the test conditions.
12. 2.