New platelet fibrinogen receptor glycoprotein IIb-IIIa antagonists: Orally active series of N-alkylated amidines with a 6,6-bicyclic template

Journal of Medicinal Chemistry

Volumn 41, Issue 21, 1998, Pages 4036-4052

  Okumura, Kunio ^a   Shimazaki, Toshiyuki ^a   Aoki, Yoji ^a   Yamashita, Hiroyuki ^a   Tanaka, Eishi ^a   Banba, Shinichi ^a   Yazawa, Kouhei ^b   Kibayashi, Kenji ^b   Banno, Hitoshi ^b  

^a MITSUI CHEMICALS INC   (Japan)

^b Mitsui Pharmaceuticals Inc   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ETHYL [6 [4 (MORPHOLINOFORMIMIDOYL)BENZAMIDO] 3,4 DIHYDRO 2H 1 BENZOPYRAN 3 YL]ACETATE HYDROCHLORIDE; FIBRINOGEN RECEPTOR ANTAGONIST; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; DOG; DRUG ACTIVITY; DRUG DESIGN; DRUG EFFECT; DRUG INDICATION; DRUG STRUCTURE; DRUG SYNTHESIS; GUINEA PIG; HUMAN; HUMAN CELL; MALE; NONHUMAN; ORAL DRUG ADMINISTRATION; THROMBOCYTE AGGREGATION INHIBITION; THROMBOSIS;

ACETIC ACIDS; ADMINISTRATION, ORAL; ANIMALS; CRYSTALLOGRAPHY, X-RAY; DOGS; FIBRINOGEN; GUINEA PIGS; HUMANS; MALE; MODELS, MOLECULAR; MORPHOLINES; PLATELET AGGREGATION; PLATELET AGGREGATION INHIBITORS; PLATELET GLYCOPROTEIN GPIIB-IIIA COMPLEX; PROTEIN BINDING; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0032497592     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm9801859     Document Type: Article

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