Temporal evolution of neuronal changes in cerebral hypoxia- ischemia in developing rats: A quantitative light microscopic study

Developmental Brain Research

Volumn 109, Issue 2, 1998, Pages 169-177

  Towfighi, Javad ^a   Mauger, David ^a  

^a PENN STATE MILTON S HERSHEY MEDICAL CENTER   (United States)

Author keywords

Brain damage; Development; Hypoxia ischemia; Rat

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; BRAIN DEVELOPMENT; BRAIN HYPOXIA; BRAIN ISCHEMIA; CONTROLLED STUDY; CORPUS STRIATUM; HIPPOCAMPUS; MICROSCOPY; NERVE CELL NECROSIS; NEWBORN; NONHUMAN; POSTNATAL DEVELOPMENT; PRIORITY JOURNAL; RAT;

ANIMALS; BRAIN; CELL COUNT; CELL DEATH; CEREBRAL CORTEX; FEMALE; HIPPOCAMPUS; HYPOXIA, BRAIN; ISCHEMIC ATTACK, TRANSIENT; NEURONS; PREGNANCY; RATS; RATS, WISTAR;

ANIMALIA;

EID: 0032497124     PISSN: 01653806     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-3806(98)00077-7     Document Type: Article

References (21)

1. Brown A.W., Levy D.E., Kublik M., Harrow J., Plum F., Brierley J.B. Selective chromatolysis of neurons in the gerbil brain: a possible consequence of 'epileptic' activity produced by common carotid artery occlusion. Ann. Neurol. 5:1979;127-138.
2. Choi D.W. Excitotoxic cell death. J. Neurobiol. 23:1992;1261-1276.
3. Deshpande J., Bergstedt K., Linden T., Kalimo H., Wieloch T. Ultrastructural changes in the hippocampal CA1 region following transient cerebral ischemia: evidence against programmed cell death. Exp. Brain Res. 88:1992;91-105.
4. Horn M., Schlote W. Delayed neuronal death and delayed neuronal recovery in the human brain following global ischemia. Acta Neuropathol. 85:1992;79-87.
5. Ito U., Spatz M., Walker J.T. Jr., Klatzo I. Experimental cerebral ischemia in Mongolian gerbils: I. Light microscopic observations. Acta Neuropathol. 32:1975;209-223.
6. Kirino T. Delayed neuronal death in the gerbil hippocampus following ischemia. Brain Res. 239:1982;57-69.
7. Kirino T., Tamura A., Sano K. Delayed neuronal death in the rat hippocampus following transient forebrain ischemia. Acta Neuropathol. 64:1984;139-147.
8. Kuroiwa T., Okeda R. Neuropathology of cerebral ischemia: recent advances in experimental studies on its pathogenesis. Pathol. Int. 44:1994;171-181.
9. Petito C.K., Feldmann E., Pulsinelli W.A., Plum F. Delayed hippocampal damage in humans following cardiorespiratory arrest. Neurology. 37:1987;1281-1286.
10. Petito C.K., Pulsinelli W.A. Delayed neuronal recovery and neuronal death in rat hippocampus following severe cerebral ischemia: possible relationship to abnormalities in neuronal processes. J. Cereb. Blood Flow Metab. 4:1984;194-205.
11. Petito C.K., Pulsinelli W.A. Sequential development of reversible and irreversible neuronal damage following cerebral ischemia. J. Neuropathol. Exp. Neurol. 43:1984;141-153.
12. Pulsinelli W.A., Brierley J.B., Plum F. Temporal profile of neuronal damage in a model of transient forebrain ischemia. Ann. Neurol. 11:1982;491-498.
13. Rice J.E., Vannucci R.C., Brierley J.B. The influence of immaturity on hypoxic-ischemic brain damage in the rat. Ann. Neurol. 9:1981;131-141.
14. Rothman S.M., Thurston J.H., Hauhart R.E. Delayed neurotoxicity of excitatory amino acids in vitro. Neuroscience. 22:1987;471-480.
15. Salford L.G., Plum F., Brierley J.B. Graded hypoxia-oligemia in rat brain: II. Neuropathological alterations and their implications. Arch. Neurol. 29:1973;234-238.
16. Schmidt-Kastner R., Freund T.F. Selective vulnerability of the hippocampus in brain ischemia. Neuroscience. 40:1991;599-636.
17. N.M. Sherwood, P.S. Timiras, A Stereotaxic Atlas of the Developing Rat Brain, University of California Press, Berkeley, 1970.
18. Thilmann R., Xie Y., Kleihues P., Kiessling M. Persistent inhibition of protein synthesis precedes delayed neuronal death in postischemic gerbil hippocampus. Acta Neuropathol. 71:1986;88-93.
19. Towfighi J., Mauger D., Vannucci R.C., Vannucci S.J. Influence of age on the cerebral lesions in an immature rat model of cerebral hypoxia-ischemia: a light microscopic study. Dev. Brain Res. 100:1997;149-160.
20. Towfighi J., Zec N., Yager J., Housman C., Vannucci R.C. Temporal evolution of neuropathologic changes in an immature rat model of cerebral hypoxia: a light microscopic study. Acta Neuropathol. 90:1995;375-386.
21. 14C] leucine incorporation into brain proteins in gerbils after transient ischemia: relationship to selective vulnerability of hippocampus J. Neurochem. 56:1991;789-796.