Preparation of 7α- and 7β-methylcholestane derivatives by kinetic separation of the diastereomeric mixture

Tetrahedron Asymmetry

Volumn 9, Issue 9, 1998, Pages 1627-1633

  Łotowski, Zenon ^a   Morzycki, Jacek W ^a   Siciński, Rafał R ^b  

^a UNIVERSITY OF BIALYSTOK   (Poland)

^b UNIVERSITY OF WARSAW   (Poland)

Author keywords

[No Author keywords available]

Indexed keywords

7ALPHA METHYLCHOLESTANE; 7BETA METHYLCHOLESTANE; CHOLESTANE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; BIOTRANSFORMATION; CHOLESTEROL METABOLISM; DERIVATIZATION; DRUG SYNTHESIS; ENZYME INHIBITION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; METHYLATION; NONHUMAN; PRIORITY JOURNAL;

EID: 0032496127     PISSN: 09574166     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0957-4166(98)00131-1     Document Type: Article

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16. 1H NMR spectrum. The 7α-methyl ketone 3a shows a characteristic signal of a pseudo-equatorial 7β-proton (dq) at 2.41 ppm, shifted downfield compared with a pseudo-axial 7α-proton in 3b at 2.04 ppm. The singlet of C(18)-methyl protons of compound 3a at 0.71 ppm integrates 3:2 versus the analogous signal of the opposite epimer 3b at 0.74 ppm.
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